Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026850 (muscular dystrophy)
 5,870 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Administration of inhibitors of prostaglandin synthetase to chicken embryos produced myopathies in their skeletal muscles which were characterized by ringbinden, hypercontraction, loss of Z disks, M bands, and thick and thin filaments. The effects of the inhibitors were reversed by administration of PGE1. The pathology of the myopathy induced in the chicken embryos was identical to that observed in human muscular dystrophy and had some features in common with other congenital myopathies. Altered prostaglandin function may therefore be directly or indirectly involved in the pathogenesis of congenital myopathies.
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PMID:Inhibition of prostaglandin synthesis produces a muscular dystrophy-like myopathy. 404 Aug 68