Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026850 (muscular dystrophy)
 5,870 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors studied the composition of isoenzymes of malic dehydrogenase in peripheral blood leucocytes of patients with Duchenne-type progressive muscular dystrophy, their mothers and sisters, and also in other primary muscular diseases. The studied group included 25 patients with Duchenne dystrophy, 20 their mothers and sisters, and 11 patients with other primary muscular diseases. The control group comprised 10 healthy subjects aged 19-40 years. Sporadically a decrease was observed of total activity and of the amount of the mitochondrial isoenzyme of MDH in Duchenne dystrophy. In one case the m-MDH isoenzyme was completely absent, this patient had most advanced disease. In the mothers of patients decreased MDH activity occurred rarely (once in 13 mothers) and the pattern of MDH isoenzymes was normal, similarly as in sisters of these patients. In other primary muscular diseases no abnormalities were found.
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PMID:[Malate dehydrogenase and its isoenzymes in the peripheral blood leukocytes in progressive muscular dystrophy of the Duchenne type]. 409 44

The activity of enzymes participating mainly in oxidative processes taking place in peripheral blood leucocytes was determined: malic dehydrogenase, glycerophosphate oxidase, and mitochondrial ATP-ase. The investigations were carried out in 29 patients with Duchenne type of muscular dystrophy, their 23 mothers, 4 sisters, and in 14 cases of other muscular dystrophies, and 4 patients with spinal muscular atrophy as well as in controls. Changes were found in the activity of these enzymes, particularly malic dehydrogenase in patients with Duchenne type of dystrophy and in some carriers of this disease.
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PMID:[Usefulness of determination of various leukocyte enzymes in progressive muscular dystrophy]. 645 75