Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026850 (muscular dystrophy)
 5,870 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Glycogen phosphorylase is a major sarcoplasmic protein and is one of the key regulatory enzymes in the control of glycogen utilisation. In C57BL/6J mice, the activity of the enzyme decreases under muscle-wasting conditions, including denervation-induced atrophy and muscular dystrophy. The cofactor of this enzyme, pyridoxal phosphate, has been employed as a specific label to permit measurement of the rate of degradation of the enzyme in vivo. In both of the muscle-wasting conditions, the decay of protein-bound label occurs at a higher rate than in normal animals, suggesting accelerated degradation of the enzyme. Additionally, we have used a monoclonal antibody, specific for pyridoxal phosphate, as a sensitive probe to search for degradation intermediates of this enzyme in vivo.
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PMID:Turnover of skeletal muscle glycogen phosphorylase. 357 81