Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0026850 (muscular dystrophy)
 5,870 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The following case report describes the successful use of distraction osteogenesis (DO) for the treatment of hypoplasia of the mandible in a patient with muscular dystrophy (MD). While DO has been used for hypoplasia of the mandible, no evidence exists that is it safe in the setting of MD. MD is a disease that primarily affects skeletal muscle; however, pathologic changes in the adjacent bone have been described. Furthermore, the healing of involved bone may be problematic, making DO a potentially unsuccessful technique in this group of patients. This report is the first successful utilization of DO for the treatment of mandibular hypoplasia in a patient with MD.
 ...
PMID:Mandibular distraction in a neonate with muscular dystrophy. 1625 6

Prior reports have advocated the use of distraction osteogenesis (DO) in the management of neonates with mandibular hypoplasia to avoid early tracheostomy and its associated morbidity. Our center recently reported on the successful use of DO in a neonate with muscular dystrophy, a condition which affects the bone as well as the adjacent skeletal muscle. Herein, we describe the use of neonatal DO for mandibular hypoplasia in the setting of amniotic band sequence (ABS). The child had significant soft tissue contracture in the region of the cheek, associated with bilateral transverse facial clefts. This report highlights the successful utilization of DO for the treatment of mandibular hypoplasia and airway compromise in a patient with ABS.
 ...
PMID:Mandibular distraction for amniotic band syndrome in the neonate. 1772 Dec 26