Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026850 (
muscular dystrophy
)
5,870
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
An enzyme that catalyzes the NADPH-dependent reduction of a wide range of aromatic and hydroxy-aliphatic aldehydes was purified from chicken breast muscle. This enzyme shares many properties with mammalian aldose reductases including molecular weight, relative substrate specificity, Michaelis constants, an inhibitor specificity. Therefore, it seems appropriate to call this enzyme an
aldose reductase
(EC 1.1.1.21). Chicken muscle
aldose reductase
appears to be kinetically identical to an
aldose reductase
that has been purified from chicken kidney (Hara et al., Eur. J. Biochem. 133, 207-214) and to hen muscle L-glycol dehydrogenase (Bernado et al., Biochim. biophys. Acta 659, 189-198). The association of this
aldose reductase
with
muscular dystrophy
in the chick is discussed.
...
PMID:Chicken muscle aldose reductase: purification, properties and relationship to other chicken aldo/keto reductases. 308 90
Several compounds that are known to inhibit mammalian aldose reductases were examined for their effects on chicken muscle
aldose reductase
(EC 1.1.1.21). Sorbinil was the most effective compound tested. Alrestatin and phenobarbital were effective inhibitors of the enzyme although their IC50 values were 10-fold more than that of Sorbinil. Indomethacin, diphenylhydantoin, phenacetin, and valproate were also inhibitors of chicken muscle
aldose reductase
but were less effective. These compounds are all non-competitive inhibitors with respect to substrate. Menadione bisulfite, a watersoluble analog of Vitamin K3 which is a substrate for carbonyl reductase but not
aldose reductase
, was a competitive inhibitor of chicken
aldose reductase
with respect to substrate. This observation is discussed with reference to the possible treatment of
muscular dystrophy
with specific inhibitor of aldose reductases.
...
PMID:Inhibition studies on chicken muscle aldose reductase. 392 23
