Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0026838 (spasticity)
 6,471 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
SPG3A protein 12.3
B3GalNAc-T2 12.3
Phospholipase DDHD2 12.3
KIAA0415 11.7
reticulon 2 11.5
SPG3 11.4
GDAP2 11.3
LYR motif-containing protein 7 11.3
NIPA1 protein 11.3
FSP2 11.3
Rab40A 11.3
Kinesin family member 5A 11.3
SPG3A 11.2
SPG10 10.9
SPG6 10.9
SPG42 10.9
SPG8 10.9
ZFYVE27 10.7
KIAA1840 10.7
C19orf2 10.7
SPAST 10.5
ATL1 10.5
atlastin-1 10.4
SPG11 10.4
RAB9B 10.3
DDHD1 10.3
ARSACS 10.3
TSEN34 10.3
FLJ10737 10.3
TIZ 10.3
REEP1 10.3
ALDH3A2 10.2
DDHD2 10.2
spastin 10.1
fatty aldehyde dehydrogenase 10.1
RTN2 10.1
ZFYVE26 10.1
ATAD3A protein 9.9
ISSX 9.9
HPDL 9.9
kyphoscoliosis peptidase 9.9
ARD1A 9.9
DNAJC11 9.9
SPG15 9.9
NIPA1 9.8
SPG7 9.8
SACS 9.8
SPG2 9.8
DARS2 9.7
ERLIN2 9.7
SPG20 9.7
TB-5 9.7
spartin 9.7
AP4B1 9.7
MRPL43 9.7
EIF2B4 9.7
phosphatidic acid-preferring phospholipase A1 9.7
CYP2U1 9.7
KIAA0196 9.6
ZC4H2 9.6
AP3D1 9.5
APOA1BP 9.5
ANKFY1 9.5
Myopalladin 9.5
1,3-N-acetylgalactosaminyltransferase 9.5
Troyer syndrome 9.4
C19orf12 9.4
C12orf65 9.4
PRUNE 9.4
EXOSC3 9.3
GTDC1 9.3
IOSCA 9.3
PLSJ 9.3
EIF2B5 9.3
AP4E1 9.3
OPA3 9.2
KIF5A 9.2
KIF1C 9.1
Bst1 9.1
C2orf37 9.1
more...
Disease
SPG19 12.3
IAHSP 12.3
Spastic quadriplegic cerebral palsy 12.3
Gaze palsy 12.3
Exacerbation of multiple sclerosis 12.3
Muscle tone abnormalities 12.3
Pectoralis minor syndrome 12.3
Fitzsimmons syndrome 12.3
Miles-Carpenter syndrome 11.7
SPG12 11.6
SPG30 11.5
SPG8 11.5
Pure hereditary spastic paraplegia 11.3
SPG33 11.3
SPG6 11.1
SPG28 11.1
SPG9 11.0
SPG10 11.0
Hereditary spastic paraplegia 11.0
Spastic ataxia 10.9
SPG4 10.9
SPG31 10.7
SPG24 10.7
SPG13 10.7
Upper motor neuron disease 10.7
Shoulder-hand syndrome 10.7
ENFL2 10.7
SPG27 10.7
SPG14 10.7
Post-thoracotomy pain syndrome 10.7
Spastic cerebral palsy 10.6
SPG11 10.5
Staphylococcal meningitis 10.3
SCA18 10.3
SPG21 10.3
HMN V 10.3
PMLD1 10.3
Localized tetanus 10.3
SACS 10.3
SPG1 10.2
SPG7 10.0
SCA25 9.9
Brainstem compression 9.9
SAX1 9.9
SCA20 9.9
SPG15 9.9
OPA3 9.8
SPG2 9.8
3-Methylglutaconic aciduria 9.8
primary lateral sclerosis 9.8
Pelizaeus-Merzbacher 9.8
Early Onset Cerebellar Ataxia 9.7
Spastic quadriparesis 9.7
Neurodevelopmental disorder 9.7
Staphylococcus epidermidis meningitis 9.7
Rotator cuff tendinitis 9.7
anal spasm 9.7
recombinant 8 syndrome 9.7
SPG20 9.6
spastic paraplegia 9.6
Partington syndrome 9.6
spastic diplegia 9.5
hyperargininemia 9.5
Focal clonic seizures 9.5
XLAG 9.5
IOSCA 9.5
Spastic quadriplegia 9.4
triplegia 9.4
Accommodative spasm 9.3
Bunionette 9.1
Kelley-Seegmiller syndrome 9.1
MGA3 9.1
Sensory deficit 8.9
mental developmental delay 8.9
Pendular nystagmus 8.9
cerebral palsy 8.9
CNS degenerative disease 8.8
spastic palsy 8.8
Cross syndrome 8.8
TORCH syndrome 8.8
more...
Symptom
Clasp-knife phenomenon 12.3
Abnormal muscle tone 12.3
spasticity 12.3
Decerebrate posture 12.3
Spastic hemiplegia 10.8
Spastic 10.1
Spastic paraparesis 10.0
athetosis 10.0
hypertonia 9.7
clonus 9.7
Flaccidity 9.7
hemiathetosis 9.7
Pyramidal signs 9.7
Ankle stiffness 9.1
Truncal ataxia 8.9
abnormal reflex 8.8
Central pain 8.6
Opisthotonus 8.6
Other pain 8.6
Neurogenic pain 8.4
disturbed speech 8.3
dystonia 8.0
Spasmodic dysphonia 8.0
blepharospasm 7.9
Hyperekplexia 7.9
paraparesis 7.8
hemiplegia 7.7
Procedural pain 7.7
hemihypesthesia 7.7
muscle stiffness 7.6
Lhermitte's sign 7.5
Central post-stroke pain 7.5
feeling sick 7.4
Peripheral neuropathic pain 7.3
dysarthria 7.3
abdominal rigidity 7.3
hypotonia 7.3
cerebellar ataxia 7.2
PAIN 7.2
intention tremor 7.1
ataxia 7.1
ataxic gait 7.1
drooling 7.0
abnormal gait 7.0
musculoskeletal impairment 6.9
Motor dysfunction 6.9
Radicular pain 6.8
paresis 6.8
clumsiness 6.8
joint stiffness 6.7
spasm 6.6
Cervical dystonia 6.6
Opposition 6.6
thoracic back pain 6.5
weakness 6.4
muscle rigidity 6.4
Bell's phenomenon 6.3
Urge incontinence 6.2
muscle cramps 6.1
myoclonus 6.1
dysesthesia 6.1
chorea 6.0
loss of balance 6.0
Urinary symptoms 6.0
torticollis 6.0
fasciculation 5.9
abiotrophy 5.9
delayed language development 5.9
shoulder pain 5.8
lumbar instability 5.8
jaw pain 5.7
personality change 5.7
bradykinesia 5.7
asterixis 5.6
Excitability 5.5
excessive sweating 5.4
neurological disability 5.4
incoordination 5.4
stump pain 5.4
neck stiffness 5.3
more...
Drug
Tezampanel 11.3
Eperisone hydrochloride 11.3
Dantrium 10.8
Sirdalud 10.7
Tolperisone hydrochloride 10.7
Lioresal 10.5
Tizanidine hydrochloride 10.4
Myobloc 9.6
Dantrolene sodium 9.5
Orphenadrine citrate 9.5
Nabilone 9.1
BOTOX 9.1
Afloqualone 9.1
Iophendylate 9.1
Botox 8.7
Oleic Acid 8.6
Rilutek 8.5
Progabide 8.4
p-Chlorophenyl 8.4
Foscavir 7.8
BoNT/A 7.2
Dibenzyline 7.2
Ditropan 7.1
9-THC 6.6
Interferon beta 6.0
Buscopan 6.0
Ziconotide 5.8
Miglustat 5.6
Sodium benzoate 5.6
Bactrim 5.6
Pantopaque 5.5
Madopar 5.4
Idebenone 5.3
NAH 5.3
Gabapentin 5.3
Modafinil 5.3
Posture 5.3
Zmax 5.2
Clonidine 5.1
Diphenhydramine 5.1
CVA 5.0
Carbidopa 4.9
Opium 4.9
Prograf 4.8
Dihydroergotamine 4.7
Trimethoprim-sulfamethoxazole 4.7
Novantrone 4.6
Isoptin 4.2
EMB 4.2
Metrizamide 4.1
Ketorolac 4.1
Duloxetine 4.0
Rimonabant 3.9
Phenytoin 3.9
Coumadin 3.9
Natalizumab 3.7
CSF 3.7
Xanthium 3.6
Rolipram 3.5
TMS 3.4
PFT 3.3
EHDP 3.3
Glutamic acid 3.3
Orphan 3.2
Sinemet 3.2
Azithromycin 3.0
Domperidone 2.9
MRC 2.8
Camp 2.8
PCP 2.7
Ganciclovir 2.7
Bupivacaine 2.7
Bayer 2.6
Norplant 2.6
Amoxicillin 2.4
Photofrin 2.4
THA 2.4
DFP 2.4
PFA 2.3
Frontal 2.3
more...
Enzyme
EC 1.2.1.48 10.7
calpain B 9.7
plasmanylethanolamine desaturase 9.3
methylglutaconyl coenzyme A hydratase 9.1
pterin-4alpha-carbinolamine dehydratase 8.7
CYP7B1 8.5
botulinum neurotoxin 8.1
5,10-methenyltetrahydrofolate synthetase 7.7
alkylglycerol monooxygenase 7.7
fatty acyl-CoA reductase 7.3
aspartyl-tRNA synthetase 7.2
methionyl-tRNA formyltransferase 6.8
m-AAA protease 6.7
aspartoacylase 6.7
pantothenate kinase 6.6
glutaryl-CoA dehydrogenase 6.5
galactocerebrosidase 6.4
Lod 6.2
CYP27A1 6.0
dihydroxyacetone phosphate acyltransferase 5.9
splicing endonuclease 5.9
tetanus neurotoxin 5.6
DSR 5.4
arylsulfatase A 5.3
phosphoserine aminotransferase 5.3
HOA 5.3
arginyl-tRNA synthetase 5.1
guanidinoacetate methyltransferase 5.1
hypoxanthine-guanine phosphoribosyltransferase 5.1
succinic semialdehyde dehydrogenase 5.0
FADS 5.0
branching enzyme 5.0
asparagine synthetase 4.9
SCS 4.9
TSR 4.8
sepiapterin reductase 4.7
glutamyl-tRNA synthetase 4.7
biotinidase 4.7
arginase 4.6
alanyl-tRNA synthetase 4.5
4-hydroxyphenylpyruvate dioxygenase 4.4
lysyl hydroxylase 4.3
CCS 4.1
phosphoglycerate dehydrogenase 3.9
GTP cyclohydrolase I 3.9
PDH 3.9
mu-calpain 3.8
adenine phosphoribosyltransferase 3.8
neuropathy target esterase 3.8
glycerol kinase 3.7
PME 3.7
alpha-L-fucosidase 3.7
hexosaminidase 3.6
methylmalonyl-CoA mutase 3.6
phospholipase A1 3.6
dihydropteridine reductase 3.6
argininosuccinate lyase 3.6
HCS 3.6
carnitine acetyltransferase 3.5
sulfite oxidase 3.5
sulfatase 3.4
dopamine beta-hydroxylase 3.4
sulfite oxidase 3.4
glucocerebrosidase 3.3
alpha-L-fucosidase 3.3
Hageman factor 3.3
alpha-L-fucosidase 3.2
CNPase 3.2
ornithine transcarbamylase 3.1
neutral sphingomyelinase 2.9
methionine adenosyltransferase 2.8
methylenetetrahydrofolate reductase 2.8
methylenetetrahydrofolate reductase 2.8
PCP 2.7
GABA transaminase 2.6
complex I 2.6
FFT 2.5
beta-secretase 2.5
mannanase 2.4
GAS 2.4
more...
Compound
Tizanidine 10.6
F-413 9.7
Botulinum toxin type A 9.6
Ketazolam 9.5
Baclofen 9.3
Dantrolene sodium 9.0
Epothilone D 7.9
Dantrolene 7.9
N-acetylaspartic acid 7.8
N-acetylaspartic acid 7.7
Spartin 7.7
Interferon beta-1b 7.4
Cyclobenzaprine 7.4
6-pyruvoyltetrahydropterin 7.3
Dibenzyline 7.1
Pantothenate 6.8
Microcephalin 6.8
Tetrahydrocannabinol 6.6
S-sulfocysteine 6.6
T 12 6.4
Cannabidiol 6.4
Trihexyphenidyl 6.3
2,3-diaminopropanoic acid 6.2
Memantine 6.2
2,3-diaminopropanoic acid 6.2
Allergan 6.1
PMP 6.1
Geigy 6.0
hexadecanal 5.9
Tiagabine 5.9
Cyproheptadine 5.8
hexadecanal 5.8
Guanidinoacetic acid 5.8
Elan 5.7
Diphenhydramine 5.7
Dihydroergotamine 5.6
A-7 5.5
Elan 5.4
Palmitoylethanolamide 5.4
Guanabenz 5.4
AG-3 5.3
Benzocaine 5.3
GA1 5.3
Riluzole 5.2
T10 5.1
A101 5.1
Moxonidine 5.0
Amantadine 4.9
Amantadine 4.9
Pyridostigmine 4.9
Amantadine 4.8
Vigabatrin 4.8
AEA 4.7
R 2010 4.7
AAA 4.6
GA2 4.6
5-HTP 4.6
AEA 4.6
5-HTP 4.5
GM2 4.5
Amantadine 4.5
Clonazepam 4.5
9-octadecenoic acid 4.5
5-formyltetrahydrofolate 4.4
Zolpidem 4.4
TCC 4.4
RELA 4.3
NFS 4.3
Ketorolac 4.2
Sulfamethoxazole 4.2
Coenzyme A 4.2
4-AP 4.2
Danazol 4.1
folinic acid 4.1
Selegiline 4.1
Clavulanic acid 4.1
gamma-aminobutyric acid 4.1
phenyl acetate 4.1
T11 4.1
Mexiletine 4.0
more...