Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0026838 (spasticity)
 6,471 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 391
MRI 238
axonal 141
Mol 116
X-linked 109
GABA 92
She 90
spastin 80
CSF 79
strabismus 42
SCI 34
endoplasmic reticulum 33
SPG11 31
hypoxanthine-guanine phosphoribosyltransferase 30
THC 27
fatty aldehyde dehydrogenase 27
SACS 26
SPG3A 26
Rett syndrome 25
SPAST 25
X-linked recessive 24
Hip 24
CB1 24
collagen 22
KCC2 22
ALS 21
A-I 21
MECP2 20
HSP 20
SPG7 20
CB2 19
MAS 19
Pol 19
ATPase 19
MIM 18
T10 17
cannabinoid receptor 17
glial fibrillary acidic protein 17
REEP1 17
L1 cell adhesion molecule 17
CBD 16
ADL 16
ubiquitin 16
TSP 16
ATL1 16
ATP 15
tap 15
L1CAM 15
AAA 15
Cx47 14
sit 14
ALD 14
KIF1A 14
ALDH3A2 14
brain-derived neurotrophic factor 14
ANOVA 14
MLC1 14
SPG10 14
atlastin-1 13
asymmetrical 13
SPG6 12
T12 12
cytokine 12
substance P 12
Silver syndrome 11
B12 11
SPG3 11
KIF5A 11
PLA2G6 11
interferon 11
Mot 10
threonine 10
frataxin 10
ROM 10
fused 10
NIPA1 10
PLP1 10
long chain 10
monocarboxylate transporter 8 10
fatty acid hydroxylase 10
thyroid hormone 10
NMDA receptor 10
TRH 10
GTPase 9
insulin 9
CYP7B1 9
PGN 9
glucose transporter 9
reserved 9
SPG 9
DARS2 9
SOD1 9
SCA1 8
anonymous 8
GBA2 8
growth hormone 8
OPA3 8
SLC2A1 8
TNF 8
ATP13A2 8
HLA 8
microsomal 8
SPG8 8
5-HT2A 7
IGF-1 7
DDHD2 7
X-linked adrenoleukodystrophy 7
non-functional 7
SCA2 7
myosin heavy chain 7
IMP 7
PANK2 7
hexosaminidase A 7
titin 7
member 1 7
cage 7
GABA(B) receptor 7
aspartyl-tRNA synthetase 7
ARSACS 7
CA3 7
JAMA 7
SPG15 7
calcitonin 7
ABC 7
EIF2B5 6
N-acetylaspartate 6
GABA-B receptor 6
Kufor-Rakeb syndrome 6
pantothenate kinase 6
T11 6
phospholipase 6
5-hydroxytryptamine 6
LL) 6
creatine kinase 6
proteolipid protein 1 6
SCS 6
GRO 6
CTNNB1 6
interferon-beta 6
proteolipid protein 6
CYP2U1 6
FES 6
aspartoacylase 6
adaptor protein 6
WDR45 6
GLD 6
AMP 6
BSCL2 6
GLUT1 6
unknown function 6
olfactory 6
ionotropic 6
SPG20 6
novel gene 6
5-HT2C 5
dopamine transporter 5
PCP 5
SCA3 5
Aristaless-related homeobox 5
glutamic acid decarboxylase 5
more...
Disease
cerebral palsy 913
stroke 807
multiple sclerosis 627
spastic paraplegia 235
epilepsy 233
depression 206
mental retardation 200
mental retardation 196
myelopathy 171
Hereditary spastic paraplegia 159
developmental delay 148
amyotrophic lateral sclerosis 146
hemiparesis 133
dementia 130
paraplegia 122
tetraplegia 122
chronic pain 105
cognitive impairment 105
encephalopathy 98
spastic diplegia 89
Parkinson's disease 85
nystagmus 83
neuropathy 82
dysphagia 79
scoliosis 73
muscular atrophy 73
incontinence 72
leukoencephalopathy 71
optic atrophy 69
decubitus 68
cancer 68
parkinsonism 66
SPG4 66
neurological disease 66
hydrocephalus 65
peripheral neuropathy 63
coma 62
Cannabis 57
movement disorder 55
brain atrophy 55
tumor 52
leukodystrophy 48
choreoathetosis 48
incontinence 48
strabismus 47
motor neuron disease 47
migraine 46
ichthyosis 43
macrocephaly 42
neurogenic bladder 39
hypertension 39
primary lateral sclerosis 37
ischemia 37
Lesch-Nyhan syndrome 36
ichthyosis 36
encephalomyelitis 35
HAM 33
SPG11 31
diplegia 31
blindness 31
severe mental retardation 31
genetic disorder 30
polyneuropathy 29
dyskinesia 29
dysplasia 29
deafness 29
fits 28
Alzheimer's disease 28
apraxia 28
osteoporosis 28
Rett syndrome 27
sexual dysfunction 27
THC 27
malnutrition 27
respiratory failure 26
trigeminal neuralgia 25
myopathy 25
arthrodesis 25
SACS 25
syringomyelia 25
cold 24
hyperargininemia 24
intellectual impairment 24
wasting 23
confusion 23
autism 23
psychosis 23
spinal cord compression 22
Friedreich's ataxia 22
diabetes 21
pneumonia 21
quadriparesis 21
Huntington's disease 21
tetanus 21
glaucoma 21
Pelizaeus-Merzbacher disease 21
Machado-Joseph disease 21
AIDS 20
Leigh syndrome 20
HSP 20
deep vein thrombosis 20
ALD 20
Krabbe disease 20
MAS 19
failure to thrive 19
sleep disturbances 18
hyperuricemia 18
meningitis 18
sensory disturbance 18
xerostomia 18
aphasia 18
sepsis 18
autoimmune disease 17
sepsis 17
diplopia 17
dysphonia 17
myelitis 17
obesity 17
SPG7 17
Dystonia 17
encephalitis 17
CNS diseases 17
West 16
metabolic disorder 16
disinhibition 16
HIV 16
schizophrenia 16
prolapse 16
arthritis 16
Syndrome 16
AAA 15
regional pain syndrome 15
retinopathy 15
abdominal aortic aneurysm 15
prematurity 15
Alexander disease 15
gastroesophageal reflux disease 15
Pelizaeus-Merzbacher 14
addiction 14
hallucinations 14
mutism 13
urinary tract infection 13
chronic disease 13
olivopontocerebellar atrophy 13
rash 13
profound mental retardation 13
alcoholism 13
leukemia 12
systemic lupus erythematosus 12
Bladder 12
SPG6 12
Bladder 12
foot drop 12
SPG10 12
malignant hyperthermia 12
Bladder 12
metachromatic leukodystrophy 12
Charcot-Marie-Tooth disease 12
anemia 11
cardiomyopathy 11
more...
Symptom
spasticity 6471
pain 912
weakness 672
ataxia 439
dystonia 431
seizures 363
hypertonia 218
hypotonia 183
fatigue 172
hemiplegia 167
spasm 149
tremor 146
paresis 131
paraparesis 129
clonus 128
dysarthria 120
cerebellar ataxia 108
anesthesia 77
headache 77
functional recovery 61
myoclonus 61
athetosis 54
sleepiness 52
blepharospasm 51
muscle stiffness 47
nausea 42
Spastic 41
constipation 41
analgesia 37
dizziness 31
shoulder pain 31
abnormal gait 30
nausea and vomiting 29
back pain 28
chorea 28
vomiting 27
paresthesia 26
agitation 26
discomfort 25
numbness 25
discomfort 25
bradykinesia 24
insomnia 24
ophthalmoplegia 24
anorexia 24
low back pain 23
joint stiffness 22
torticollis 21
thinning 21
cancer pain 19
drooling 18
muscle rigidity 18
asthenia 18
fasciculation 16
ataxic gait 15
lethargy 15
incoordination 15
cough 15
myalgia 15
dyspnea 14
dysesthesia 13
muscle cramps 13
cachexia 12
clumsiness 12
neck pain 11
hypothermia 10
intention tremor 10
dysuria 9
vertigo 9
twitching 9
exhaustion 8
diarrhea 8
arthralgia 8
neuralgia 8
neurological disability 8
splenomegaly 7
hepatosplenomegaly 7
Spastic paraparesis 7
hip pain 6
blurred vision 6
personality change 6
consciousness disturbance 6
pelvic pain 6
loss of balance 6
Ill 5
hepatomegaly 5
distraction 5
leg pain 5
collapse 5
Stiffness 5
pallor 5
neck stiffness 5
abnormal reflex 5
angina 5
excessive sweating 5
starvation 4
Central pain 4
respiratory distress 4
hyperesthesia 4
urinary frequency 4
abdominal pain 4
photophobia 4
Pyramidal signs 4
Hyperekplexia 4
limb pain 4
Opposition 4
Neuropathic pain 4
skin irritation 4
lightheadedness 4
tachypnea 3
Spasmodic dysphonia 3
erythema 3
motor symptom 3
Excitability 3
tingling 3
livedo 3
enuresis 3
acute abdomen 3
facial pain 3
chronic constipation 3
Spastic hemiplegia 3
Postoperative pain 3
bone pain 3
decreased appetite 3
tonic-clonic seizure 3
Lhermitte's sign 3
acute pain 3
stridor 2
Ankle stiffness 2
Sedation 2
hypercapnia 2
Cervical dystonia 2
apathy 2
dry eye 2
Other pain 2
chest pain 2
Motor dysfunction 2
No adverse effect 2
asterixis 2
PAIN 2
bladder pain 2
fever of unknown origin 2
Wind 2
jaw pain 2
arm pain 2
hopelessness 2
memory loss 2
hemihypesthesia 2
ACHE 1
syncope 1
arm weakness 1
acute low back pain 1
Procedural pain 1
partial seizure 1
lumbar instability 1
hoarseness 1
intestinal bleeding 1
orthopnea 1
musculoskeletal impairment 1
catatonia 1
more...
Drug
CSF 80
Posture 42
Botox 36
9-THC 33
BoNT/A 26
BOTOX 19
Clonidine 17
Dermatol 17
Dantrolene sodium 16
Lioresal 14
Myobloc 9
lysine 8
Diphenhydramine 7
ABC 7
Dantrium 7
Gabapentin 7
Sirdalud 6
Monit 6
Nabilone 6
PCP 5
MRC 5
TMS 5
caffeine 5
nitroglycerin 4
Tizanidine hydrochloride 4
Phenytoin 4
Cardiovasc 3
Progabide 3
CTX 3
Eperisone hydrochloride 3
Modafinil 3
CVA 3
Xanthium 2
Frontal 2
Zmax 2
CAM 2
Azithromycin 2
Bactrim 2
Albumin 2
Trimethoprim-sulfamethoxazole 2
Glycerol 2
Interferon beta 2
Bayer 2
Metrizamide 2
HCH 2
Nitric Oxide 2
EHDP 1
DPA 1
Sinemet 1
Iophendylate 1
Orphenadrine citrate 1
Horizon 1
ampicillin 1
Photofrin 1
Glutamic acid 1
Leaf 1
Natalizumab 1
Miglustat 1
Dibenzyline 1
Rolipram 1
Camp 1
PFA 1
lactose 1
Sodium benzoate 1
THA 1
Amoxicillin 1
Foscavir 1
NAH 1
AZT 1
Bupivacaine 1
CTX 1
DFP 1
Dihydroergotamine 1
Afloqualone 1
Rimonabant 1
Tacrolimus 1
Ditropan 1
MDS 1
Growth hormone 1
Norplant 1
Check 1
Vitamin B12 1
Cimetidine 1
Adriamycin 1
IFN-gamma 1
Carbidopa 1
Orphan 1
Idebenone 1
Acyclovir 1
ascorbate 1
Oleic Acid 1
CTX 1
NADH 1
Ranitidine 1
Cimetidine 1
Isoptin 1
Coumadin 1
Vitamin E 1
Itraconazole 1
Opium 1
Prednisolone 1
-deoxyadenosine 1
Growth hormone 1
Norplant 1
Tolperisone hydrochloride 1
Alliance 1
niacin 1
Fentanyl 1
Ganciclovir 1
Buscopan 1
Ketorolac 1
Pantopaque 1
vitamin E 1
Tezampanel 1
Duloxetine 1
DHT 1
Ziconotide 1
Retinoic acid 1
DHT 1
BH4 1
Rilutek 1
Prograf 1
PTH 1
EMB 1
AZT 1
Madopar 1
Dial 1
ROS 1
IFN-beta 1
Scopolamine 1
p-Chlorophenyl 1
PFT 1
Domperidone 1
Novantrone 1
Enzyme
botulinum neurotoxin 103
ATPase 21
arginase 19
hypoxanthine-guanine phosphoribosyltransferase 18
complex I 11
creatine kinase 9
hexosaminidase 9
acetylcholinesterase 9
CYP7B1 9
sulfatase 7
superoxide dismutase 7
galactocerebrosidase 7
aspartyl-tRNA synthetase 7
focal adhesion kinase 7
CYP27A1 7
ERK 6
cholinesterase 6
catalase 6
SCS 6
PCP 5
arylsulfatase A 5
pantothenate kinase 5
alkaline phosphatase 5
RNA polymerase 5
glutaryl-CoA dehydrogenase 4
aspartoacylase 4
ACE 4
beta-galactosidase 4
kinesin 4
branching enzyme 4
methylenetetrahydrofolate reductase 3
mitogen-activated protein kinase 3
NO synthase 3
cathepsin D 3
beta-glucosidase 3
glucocerebrosidase 3
neuropathy target esterase 3
alanine aminotransferase 3
pyruvate dehydrogenase 3
cytochrome oxidase 3
Lod 3
ornithine transcarbamylase 3
dopamine beta-hydroxylase 3
asparagine synthetase 3
reverse transcriptase 3
choline acetyltransferase 3
methylenetetrahydrofolate reductase 3
phospholipase A2 3
transcriptase 3
thromboplastin 2
alpha-L-fucosidase 2
caspase-3 2
alcohol dehydrogenase 2
neuraminidase 2
adenosine deaminase 2
P-glycoprotein 2
adenylate cyclase 2
proteasome 2
sialidase 2
ACS 2
PDH 2
phospholipase C 2
citrate synthase 2
mu-calpain 2
collagenase 2
biotinidase 2
protein kinase 2
succinic semialdehyde dehydrogenase 2
beta-glucosidase 2
GTP cyclohydrolase I 2
NADPH-diaphorase 2
adenine phosphoribosyltransferase 2
hyaluronidase 2
aldehyde dehydrogenase 2
hyaluronidase 2
ceruloplasmin 2
APC 2
aldehyde dehydrogenase 2
glycerol kinase 2
fatty acyl-CoA reductase 2
adenosine deaminase 2
aldehyde dehydrogenase 2
aldehyde dehydrogenase 2
phosphodiesterase 2
CD10 2
tetanus neurotoxin 2
aldehyde dehydrogenase 2
tyrosine hydroxylase 2
CCS 2
alpha-L-fucosidase 1
arginyl-tRNA synthetase 1
PDE 1
phospholipase D 1
methylmalonyl-CoA mutase 1
ribonucleotide reductase 1
MMP 1
glutamate decarboxylase 1
TSR 1
ribonucleotide reductase 1
monoamine oxidase 1
triphosphatase 1
splicing endonuclease 1
phosphatidylinositol 3-kinase 1
PME 1
methionyl-tRNA formyltransferase 1
FADS 1
5,10-methenyltetrahydrofolate synthetase 1
renin 1
Thy1 1
AMPK 1
aspartate aminotransferase 1
glutathione peroxidase 1
DNA polymerase 1
alpha-L-fucosidase 1
NQO1 1
NOS 1
argininosuccinate lyase 1
AMP-activated protein kinase 1
gamma-glutamyl transpeptidase 1
m-AAA protease 1
Hageman factor 1
alanyl-tRNA synthetase 1
RNase 1
sepiapterin reductase 1
phosphoserine aminotransferase 1
CNPase 1
glyceraldehyde-3-phosphate dehydrogenase 1
mannanase 1
glyceraldehyde-3-phosphate dehydrogenase 1
GABA transaminase 1
MEK 1
DSR 1
alkylglycerol monooxygenase 1
CAD 1
plasmanylethanolamine desaturase 1
acid phosphatase 1
ECH 1
sulfite oxidase 1
glyceraldehyde-3-phosphate dehydrogenase 1
pepsin 1
carnitine acetyltransferase 1
sulfite oxidase 1
CAD 1
methionine adenosyltransferase 1
methylglutaconyl coenzyme A hydratase 1
carboxylesterase 1
dihydroxyacetone phosphate acyltransferase 1
fumarase 1
calpain B 1
DAT 1
AMPK 1
chaperonin 1
beta-secretase 1
GAS 1
diaphorase 1
protein kinase C 1
FFT 1
6-phosphogluconate dehydrogenase 1
lysyl hydroxylase 1
lipase 1
more...
Compound
Clin 481
Dec 415
Baclofen 160
GABA 97
GABA 94
DNA 86
phenol 84
His 72
sodium 64
gamma-aminobutyric acid 53
glutamate 50
calcium 47
water 42
Botulinum toxin type A 41
glucose 38
oxygen 38
iron 30
Tizanidine 29
arginine 29
potassium 29
urea 24
5-HT 20
Dantrolene 19
ammonia 19
Diazepam 18
ethanol 18
T10 17
phosphate 16
AAA 15
ATP 15
serine 15
L-DOPA 14
creatinine 12
acetate 11
NMDA 11
nitric oxide 11
Phe 11
Tetrahydrocannabinol 11
threonine 10
PMA 10
Neuronal 10
Gly 10
Optimal 10
Dantrolene sodium 10
TRH 10
hydrogen 10
N-acetylaspartate 9
lysine 9
alanine 9
Memantine 9
5-hydroxytryptophan 9
iodine 9
barium 8
GM2 8
nitrogen 8
Cannabidiol 8
TNF 8
Allergan 7
Diphenhydramine 7
IMP 7
AMPA 7
glutamine 7
sulfate 7
glycerol 7
noradrenaline 7
AEA 7
folinic acid 6
copper 6
silver 6
T11 6
methionine 6
cysteine 6
PEG 6
PMP 6
Pantothenate 6
phosphorus 6
PCP 5
tryptophan 5
GTP 5
Cardiol 5
caffeine 5
hexane 5
ornithine 5
glutamic acid 5
butyric acid 5
Asp 5
A 3 5
proline 5
CO2 5
butyric acid 5
salt 5
valine 5
ornithine 5
butyric acid 5
nicotinamide 5
galactose 5
ornithine 5
ornithine 5
ornithine 5
Glutamate 5
HCl 4
CIT 4
5-HTP 4
ASA 4
DPH 4
acrylamide 4
AMP 4
GA1 4
selenium 4
5-HTP 4
aldehyde 4
4-AP 4
Guo 4
AEA 4
bromide 4
CoA 4
Guo 4
A 42 4
TCC 4
neopterin 4
Neurotol 4
Thyroid 4
aldehyde 4
4-chlorophenyl 3
NADPH 3
cAMP 3
acetamide 3
tyrosine 3
zinc 3
N-acetylaspartic acid 3
Geigy 3
ammonium 3
acetic acid 3
tryptophan 3
5-HIAA 3
molybdenum 3
leucine 3
Amantadine 3
Morphine 3
N-acetylaspartic acid 3
Serine 3
Amphotericin B 3
CTX 3
Salt 3
ACh 3
Lactate 3
Amantadine 3
Cyproheptadine 3
Retinal 3
methanol 3
phosphocreatine 3
Riluzole 3
vitamin D 3
asparagine 3
NADPH 3
RELA 3
MCA 3
ACTH 3
acetonitrile 3
MTT 3
more...