Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026838 (spasticity)
 6,471 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 59 year-old male marathon runner presented with recent diagnosis of hereditary spastic paraplegia in setting of gait deviation and spasticity. He noted asymmetric wear pattern of his right shoe and toe drag, with recent development of left lower extremity pain and cramping attributed to spasticity. He elected to proceed with radial extracorporeal shockwave treatment (R-SWT) targeting affected muscles. The night following initial treatment, he was able to run 2 minutes per mile faster over a 4 mile run with resolution of toe drag. He completed 6 sessions of R-SWT along with maintaining regular cardiovascular exercise and strength training. He was seen 6 weeks after series of treatment with recent worsening and toe drag that recurred. He completed further sessions with return to improved function seen following his initial series of shockwave and ability to return to running up to 13 miles. His neurological symptoms remained controlled without noted progression. This case illustrates the potential use of R-SWT in spasticity management of hereditary spastic paraplegia and that more frequent sessions may be required to maintain benefits of treatment.
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PMID:Improved function in a runner with hereditary spastic paraparesis with use of extracorporeal shockwave therapy: personal clinical experience. 3273 47

A 37 year-old previously healthy man from Jamaica presented with 2-3 months of progressive trouble ambulating and incontinence. By 1 month prior to arrival he was wheelchair bound and unable to ambulate even with assistance. He started to wear a diaper for bladder and bowel incontinence. He also complained of painless numbness in his legs over the same period of time. His exam is notable for marked weakness and spasticity in his legs, with hyper-reflexia and clonus. He has a sensory level at the level of the umbilicus. An MRI shows a longitudinally extensive T2 signal change throughout the thoracic cord. His cerebrospinal fluid is mildly inflammatory. His HTLV-1 antibody test is reactive.
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PMID:The case of a 37-year-old male with trouble ambulating and incontinence. 3294 3


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