Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026838 (spasticity)
 6,471 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Disseminated angiokeratomas can be seen in patients with an inherited deficiency of alpha-l-fucosidase as well as in patients with classic Fabry's disease. Patients with deficiency of this lysosomal enzyme, or fucosidosis, have spasticity, mental retardation, and retardation of growth in addition to angiokeratomas. We herein report three new cases of this rare syndrome.
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PMID:Fucosidosis. 40 53

Experiments were carried out in awake, unmedicated monkeys to determine the effect of application of current to the cerebellar hemispheres on electrically induced focal motor seizures and surgically induced spasticity. Application of current at various frequencies and pulse amplitudes did not significantly alter focal motor seizures but did significantly reduce spasticity. Analysis of evoked potential recordings carried out during various experimental procedures suggests that application of current to the cerebellar hemispheres may reduce cortical neuronal responsiveness.
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PMID:The effect of cerebellar stimulation on focal seizure activity and spasticity in monkeys. 40 55

Some common, yet erroneous, attitudes and perceptions about stroke still persist. These warrant reconsideration: (1) benefits of stroke rehabilitation (including validity of its basis, life expectancy, adequacy in nursing homes, outcome prediction, cost benefits, and vocational outcome); (2) gait training (including evaluation methods, gait patterns, hand supports, sensory deficits, and types of braces); (3) effects of training on regaining balance; (4) spasticity (as a negative factor, enhancement by spring-action brace, benefit of inhibition training, and importance of antispasmotic drugs); (5) danger of early activity; (6) depression; (7) effects on patients' sexuality; (8) effects of communication impairments on learning abilities as well as effectiveness of speech therapy; (9) application of neurphysiological principles (regarding decreasing synaptic resistance, applications of principles from cerebral palsy training, and benefits of training for percept-concept-motor function deficits); and (10) research including reliability of past reports and paucity of facilities for new research.
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PMID:Stroke rehabilitation: a reconsideration of some common attitudes. 41 97

We have reviewed approximately 150 patients who were treated with supportive measures for facial paralysis. We found that in the patient's view an adequate result requires establishment of a proper lip sphincter--either by restoring muscular tone, or by creating an anatomical framework to which can be added either a motor unit or stabilization to aid the opposite intact muscle. We also found lasting value from dampening contralateral spasticity, and from the use of such ancillary procedures as the face lift, the brow lift, and the creation of a nasolabial fold. It is important for the physician to help the patient acquire a tranquil face during speech and emotion by persevering in mirror training and mimetic gymnastics.
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PMID:Review of long-term results in supportive treatment of facial paralysis. 41 98

The intradiscal lumbar pressure was measured in 10 patients with para- or tetraplegia and in one normal subject. The pressure was registered both in the horizontal position and during tilting on a table, during the performance of a standardized exercise program for the upper extremities, as well as during cough, during abdominal strain and while the subjects were being turned from the supine to the lateral position. The increase in pressure during the tilting to an angle of +30 degrees, and mostly to +50 degrees was less than the maximum pressure change during the exercises to which an immobilized patient with acute unstable fracture of the spine, was exposed daily, such as being turned, performing respiratory exercises and muscular training for the upper extremities. Provided fixation was secured with a belt, patients with unstable fractures of the thoracic and lumbar spine maybe treated with a "more active immobilization" tilting them in the bed even during the acute stage. Forward flexion exercises in the shoulder joints with hand weights produced a greater increase of the intradiscal pressure than did abduction exercises with the corresponding load. Spasticity produced a considerable increase in intradiscal pressure.
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PMID:Disc pressure measurements in para- and tetraplegic patients. A study of of mobilization and exercise in para- and tetraplegic patients. 41 93

Dantrolene sodium is a muscle relaxant used in the treatment of spasticity. It has been shown to interfere with calcium release from the sarcoplasmic reticulum and thus to inhibit excitation--contraction coupling. The effect of dantrolene sodium on the twitch tension of the tibialis anterior muscle of the rat was measured after 2 mg/kg i.v. or 25 mg/kg orally. Plasma concentrations were estimated at maximum twitch depression and during recovery from the block. In a separate series of experiments the half-life of labelled dantrolene sodium was measured in blood plasma, skeletal muscle and heart muscle of rats. Dantrolene sodium 2 mg/kg i.v. gave a maximal block of approximately 47%, the mean dantrolene sodium concentration was then 5.8 microgram/ml. A half-life for distribution of 1.1 min and an elimination half-life of 31 min after intravenous administration were observed, elimination rate constants in skeletal and heart muscle were comparable. Recovery from the block went much slower, the half-time of the process being approximately 80 min. Dantrolene sodium 25 mg/kg orally gave a maximal block of approximately 38% at a mean plasma concentration of 3.6 microgram/ml after 14 min. The recovery was again very slow. These experiments demonstrated that dantrolene sodium acts according to a two-compartment pharmacokinetic model. There was a discrepancy between duration of effect and plasma concentration of dantrolene sodium in the rat. This suggests that the receptor for dantrolene sodium is not located in the central compartment.
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PMID:The effect of dantrolene sodium on rat skeletal muscle in relation to the plasma concentration. 42 31

A male infant with ornithine transcarbamylase (OTC) deficiency is described who was relatively symptom free for 4 months, gradually developed severe spasticity due to cerebral atrophy, and died at 13 months of age. Liver OTC activity was 1.5% of the normal mean. The mutant OTC showed an increased apparent Km for ornithine and an increased pH optimum. These kinetic findings fail to explain the atypical clinical course. The clinical picture of patients with genetic OTC deficiency who present during acute exacerbations together with the elevation of serum glutamic oxaloacetic transaminase and microvesicular fat accumulation in liver, as seen in this case, may suggest Reye's syndrome; however, electronmicroscopic examination of this patient suggested that the normal appearance of mitochondria helps to distinguish the two.
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PMID:Atypical clinical course of ornithine transcarbamylase deficiency due to a new mutant (comparison with Reye's disease). 42 91

Patients with spinal cord injury or multiple sclerosis were surveyed for the presence of extreme foot deformities and spasticity. Pes cavus and claw toes were found in eight of 80 spastic spinal cord injury and two of 20 multiple sclerosis patients. Pes cavus and claw toes were not found in 29 flaccid spinal cord injury patients. Pes cavus and claw toes were associated with flexor reflexes which could be elicited by pin prick proximal to the knee, suggesting extreme spasticity--and by low excitatory thresholds for the anterior tibialis as indicated electromyographically. Complications of severe spasticity associated with spinal cord injury and multiple sclerosis include pes cavus and claw toes, mediated in part by spasms of the anterior tibialis.
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PMID:Pes cavus and claw toes deformity in patients with spinal cord injury and multiple sclerosis. 43 69

A polystyrene bead vacuum wheelchair cushion has been tried with several patients with abnormal postural reflex activity. Excess spasticity can be reduced by this means and sitting comfort enhanced.
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PMID:The polystyrene vacuum wheelchair cushion. 43 73

A procedure has been devised for treatment of the inability to extend the elbow due to either a fixed contracture of the flexor muscles or increased involuntary flexor-muscle tone and spasticity. The operation consists of lengthening all of the primary elbow-flexor muscles. It has been used successfully in thirty-two elbows of twenty-six children with cerebral palsy who were followed for an average of four years (range, two through six years). The average gain in extension was 40 degrees, and there was no loss of the patient's ability to flex the elbow or supinate the forearm. No vascular or neural complications were encountered. Independence in feeding was achieved in four patients. Seven patient acquired the ability to engage in sports and six, who previously had been unable to walk independently due to inability to handle crutches, could do so following this procedure.
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PMID:Lengthening of the elbow flexors in cerebral palsy. 43 38


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