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Query: UMLS:C0026838 (spasticity)
 6,471 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Data are presented for the first 50 patients with cerebral palsy who underwent chronic cerebellar stimulation for symptom alleviation. We observed significant shorter and longer term improvement in spasticity as well as athetosis, speech, and functional status. Continuing increments in improvement were noted as a function of time on stimulation. In many instances, psychometric test scores and behavior also were improved. There was one death in this series. There were no neurologic complications due to cerebellar stimulation. The results of this study warrant the judicious use of cerebellar stimulation for symptomatic and functional relief in cerebral palsy.
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PMID:Chronic cerebellar stimulation in cerebral palsy. 108 66

Ten children with cerebral palsy are presented on whom stereotaxic operations on the central nervous system were performed with the aim of ameliorating athetosis and spasticity. Tere were seven alert and co-operative children with spastic hemiplegia or diplegia, of whom six received benefit from thalamotomy or dentatotomy. The seventh, a child with diplegia, had improvement of his left lower limb, but the right became worse. One child with spastic diplegia, in whom a thoracic meningocoele had been closed at birth, was not improved by bilateral dentatotomy. Two severely quadriplegic children each had bilateral dentatotomy; one was a child with dystonic and spastic quadriplegia. In both cases the resulting reduction in tone and extensor spasm rendered the nursing of these patients much easier. The place of stereotaxic surgery in the central nervous system in the management of children with cerebral palsy is discussed. We suggest that in selected cases the stereotaxic operation should be performed early in order to gain the greatest benefit. Stereotaxic surgery should be regarded as an integral part of the management which involves close co-operation of paediatrician, physiotherapist, neurosurgeon and orthopaedic surgeon.
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PMID:Stereotaxic neurosurgery in the management of cerebral palsy. 110 96

A third case of hyperargininaemia occurring in one family was studied from birth. In cord blood serum arginine concentration was only slightly raised, but arginase activity in red blood cell haemolysates was very low. In the urine on day 2 a typical cystinuria pattern was present. Arginine concentration in serum increased to 158 mumol/100 ml on the 41st day of life. Later determinations of the arginase activity in peripheral blood showed values below the sensitivity of the method. Blood ammonia was consistently high, and cystinuria was present. The enzymatic defect was further displayed by intravenous loading tests with arginine. Serum urea values were predominantly normal or near the lower limit of normal, suggesting the presence of other metabolic pathways of urea synthesis. In urine there was no excretion of guanidinosuccinic acid, while the excretion of other monosubstituted guanidine derivatives was increased, pointing to a connexion with hyperargininaemia. Owing to parental attitude, a low protein diet (1-5 g/kg) was introduced only late. The infant developed severe mental retardation, athetosis, and spasticity.
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PMID:Familial hyperargininaemia. 112 44

Disease and trauma to the central and peripheral nervous system can result in various disturbances to the stability and mobility of the knee joint. The aims of orthopaedic treatment in flaccid paralysis, spasticity, rigidity, athetosis and ataxia are discussed. The effect on the musculo-skeletal system is most severe when the damage occurs prenatally. The tendency to deformity in perinatal cerebral spastic disorders of movement can be considerably reduced by early systematic functional treatment. Active and passive exercise, corrective and reflex inhibiting casts and orthoses have proved their value in the prevention and treatment of muscle contractures in flaccid paralysis and spasticity. The dangers of treatment, such as subluxation of the knee and hip joint, osteoporotic fractures, and traction paralysis, must be taken into account. Muscle contractures often hinder function, both in spasticity and in flaccid paralysis, more than the underlying disease. The operative treatment of flexion contractures and impaired knee flexion in the swing phase of the step is discussed. Gait analysis facilitates the planning of treatment. The hip, knee and ankle joints must be treated as a single functional unit.
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PMID:[Treatment concepts in knee malposition within the scope of primary neurologic diseases]. 140 26

The results of stereotactic surgery in 38 patients with cerebral palsy are reviewed. A total of 67 nuclei were approached and 109 stereotactic lesions performed. The motor disorders were spasticity, athetosis, dystonia and tremor. The targets were chosen according to the motor disorder, and included the pulvinar, ventrolateral (VL), sub-VL and cerebellar dentate, and a combination of 2 or 3 of these. The results of the surgery were evaluated on the basis of objective functional improvement using a scale for task achievement. Varying degrees of overall improvement were found in over 80% of the patients; these are discussed in detail.
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PMID:Stereotactic surgery for cerebral palsy. 208 Mar 27

The main neurosurgical forms of infantile cerebral palsy (ICP) are singled out: athetosis-torsional-dystonic, athetosis-spastic, athetosis-torsional-choreatic. Results of 273 stereotaxic operations in 163 ICP patients are analyzed. The best results were observed in with athetosis-choreatic and athetosis-torsional-dystonic forms that were associated with rigidity-spasticity.
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PMID:[Stereotaxic operations in the treatment of patients with infantile cerebral palsy]. 268 60

Results of 202 obturator neurectomies including 190 intrapelvic and 8 extrapelvic obturator neurectomies in 100 patients were evaluated. Obturator neurectomy, intrapelvic in particular, yielded gratifying results in properly selected patients. It controlled adductor spasticity, scissoring, improved perineal care and helped the patients in sitting and early ambulation. Pre- and post-operative intensive physiotherapy was necessary to get maximum benefit of the surgery. Poor motor status, low IQ, athetosis and inadequate post-operative care had adverse effect on final outcome.
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PMID:Intrapelvic obturator neurectomy in cerebral palsy. 280 53

Authors report a study concerning 12 dyskinetic patients with cerebral palsy. The clinical pre-operative examination shows that many signs and symptoms are associated: volitional and postural dyskinesia, athetosis and dystonia, pyramidal deficit and spasticity. Talairach's stereotactic methodology has been used for bifocal (VPL thalamic nucleus and internal pallidum) Yttrium 90 implantation. After stereotactic bifocal lesions, involuntary movements have been reduced in 45.5% of cases and have disappeared in 27% of cases. Impairment of previous motor deficit has been observed in 3% of cases; volitional and postural dyskinesia seems to be the most curable symptomatology. Clinical results in athetoid involuntary movements and dystonia are less rewarding. Because of important anatomical modifications often observed cerebral palsy patients, the authors stress the interest of individual acute neurophysiological study and discuss about the stereotactic targets and the modalities of destruction. They insist upon the necessity of rigorous selection of indications based on acute clinical examination in the perspective of improvement of global functional capacities.
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PMID:[Value of bifocal stereotaxic destruction in case of dyskinesia in patients with a motor deficit of cerebral origin]. 332 99

We have performed selective posterior rhizotomies on 60 children with cerebral palsy. The procedure involves lumbar laminectomy with stimulation of the rootlets (fascicles) of the second lumbar to the first sacral posterior roots bilaterally; those rootlets associated with an abnormal motor response, as evidenced by sustained or diffused muscular contraction, are divided leaving intact rootlets associated with a brief localized contraction. The patients were between 20 months and 19 years of age representing all degrees of physical handicap and ranging from profoundly retarded to normal intelligence. Follow-up has been from 1 to 5 years. Each child was assessed pre- and postoperatively and graded in the following categories: muscle tone, power, sitting, standing, walking, upper limb function, and speech. The patients whose function improved most dramatically following rhizotomy were purely spastic and intelligent, were significantly more affected by spasticity in the lower than the upper limbs, had some degree of forward locomotion, and could side-sit independently. Patients with severe athetosis or marked contractures improved least.
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PMID:Cerebral palsy spasticity. Selective posterior rhizotomy. 343 16

This study was conducted to determine the effect of body orientation on upper extremity function in children and adolescents with cerebral palsy. Thirteen children between ages 8 and 16 and diagnosed as having spastic or athetoid cerebral palsy were placed randomly in different seating orientations (30 degrees, 15 degrees, and 0 degrees of posterior inclination and 15 degrees of anterior inclination). In each seating position, the subject performed an upper extremity activity on cue. The tests were repeated in reverse sequence. Mean performance times were different at all seating orientations for both types of subjects. Performance time was lowest at the 0-degree orientation during the retest for the subjects with spasticity and highest at 15-degree anterior inclination during the retest for the subjects with athetosis. The results of this study show that orientation of the body in space affects upper extremity function and emphasizes the importance of positioning for maximizing upper extremity function.
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PMID:Seating orientations and upper extremity function in children with cerebral palsy. 361 89


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