Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026838 (spasticity)
 6,471 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty-seven patients with pain due to the imbalance of the body were examined. Clinical evaluation of patients before and after treatment included a general orthopedic examination, computer optical topography, surface electroneuromyography. The main group (17 patients) received injections of the drug lantoks in spastic muscles, the control group received a standard set of treatment to relieve spasticity (massage, exercise therapy, FTL, pharmacotherapy). The treatment gave a significant difference between the main and control groups in the results of changing the parameters of posture and electrophysiological parameters of muscle as well as the duration of pain relief. The results of the study confirm a significant impact of the local muscle relaxation on the parameters of posture. The high efficacy of "Lantoks" in the reconstruction of functional parameters in the groups of spastic muscles was shown.
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PMID:[The use lantoks as a step in the treatment of tonic pain in patients with impaired body balance]. 2443 56

Neurodegeneration with brain iron accumulation (NBIA) is a group of inherited heterogeneous neurodegenerative rare disorders. These patients present with dystonia, spasticity, parkinsonism and neuropsychiatric disturbances, along with brain magnetic resonance imaging (MRI) evidence of iron accumulation. In sum, they are devastating disorders and to date, there is no specific treatment. Ten NBIA genes are accepted: PANK2, PLA2G6, C19orf12, COASY, FA2H, ATP13A2, WDR45, FTL, CP, and DCAF17; and nonetheless, a relevant percentage of patients remain without genetic diagnosis, suggesting that other novel NBIA genes remain to be discovered. Overlapping complex clinical pictures render an accurate differential diagnosis difficult. Little is known about the pathophysiology of NBIAs. The reported NBIA genes take part in a variety of pathways: CoA synthesis, lipid and iron metabolism, autophagy, and membrane remodeling. The next-generation sequencing revolution has achieved relevant advances in genetics of Mendelian diseases and provide new genes for NBIAs, which are investigated according to 2 main strategies: genes involved in disorders with similar phenotype and genes that play a role in a pathway of interest. To achieve an effective therapy for NBIA patients, a better understanding of the biological process underlying disease is crucial, moving toward a new age of precision medicine.
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PMID:On the complexity of clinical and molecular bases of neurodegeneration with brain iron accumulation. 2854 92