Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026838 (spasticity)
 6,471 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Five years' experience with the implantation of permanent magnets in the eye lids for reconstruction of dynamic lid closure for paretic lagophthalmos is presented. The patients followed up were 114 in number with unilateral and three with bilateral lagophthalmos due to complete facial palsy. In the majority of cases satisfactory to good eyelid function with complete protection for the eye could be obtained. In 15 cases rejection occurred usually because of deficient implantation technique. On the basis of these experiences we conclude that a good indication for lid magnet implantation is present for reversible facialis paralysis for a continuous solution, and also as a complement to other operative procedures which alone do not result in complete eyelid closure. Facial paralysis of long duration with atrophy of the lid structures and retraction or spasticity of the levator musculature is a relative contraindication.
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PMID:[Five years experience with lid magnet implantation for paretic lagophthalmos (author's transl)]. 60 63

Botulinum toxin blocks acetylcholine release at the neuromuscular junction. The drug which was initially found to be useful in the treatment of strabismus has been extremely effective in the treatment of variety of conditions, both cosmetic and noncosmetic. Some of the noncosmetic uses of botulinum toxin applications include treatment of spastic facial dystonias, temporary treatment of idiopathic or thyroid dysfunction-induced upper eyelid retraction, suppression of undesired hyperlacrimation, induction of temporary ptosis by chemodenervation in facial paralysis, and correction of lower eyelid spastic entropion. Additional periocular uses include control of synchronic eyelid and extraocular muscle movements after aberrant regeneration of cranial nerve palsies. Cosmetic effects of botulinum toxin were discovered accidentally during treatments of facial dystonias. Some of the emerging nonperiocular application for the drug includes treatment of hyperhidrosis, migraine, tension-type headaches, and paralytic spasticity. Some of the undesired side effects of periocular applications of botulinum toxin inlcude ecchymosis, rash, hematoma, headache, flu-like symptoms, nausea, dizziness, loss of facial expression, lower eyelid laxity, dermatochalasis, ectropion, epiphora, eyebrow and eyelid ptosis, lagophthalmos, keratitis sicca, and diplopia.
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PMID:Noncosmetic periocular therapeutic applications of botulinum toxin. 2061 16