Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0026838 (spasticity)
 6,471 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 124 patients with extramedullary tumors of different histological structure atypical syndromes were detected in 61% and were verified by surgical methods. The following atypical syndromes were marked: a nonconformity of the level of sensorial conductivity and the level of the tumor (19%), a dissociated type of spasticity of a cervico-thoracal localization (17%), disorder of cranial innervation (23.4%), swelling of the optic papilla (2.4%), etc. The pathogenesis of these changes was most frequently conditioned by hemo- and liquor dynamical disturbances, as well as by intoxication. Diagnostical errors related to the character of the process were seen in 18.5%, topico-diagnostical discrepance--in 19.3%.
 ...
PMID:[Atypical symptoms and their pathogenesis in extrapyramidal tumors]. 89 81

A rare case of intramedullary schwannoma of the spinal cord has been reported, The patient was a 30-year-old woman, who began to notice weakness in her right leg approximately 6 months prior to admission, followed 4 months later by numbness and weakness of the right arm. The above symptoms were progressively getting worse, and she was admitted to Hokkaido University Hospital on February 23, 1974. Neurological examination revealed slow speech, bilateral horizontal nystagmus, absent gag reflex and weakness of right trapezius muscle. Spasticity was noted in 4 extremities, in addition to right hemiparesis. All deep tendon reflexes were hyperactive, right more than left, with bilateral Hoffmann's and Babinski's signs. Vibration sense was diminished below the level of bilateral iliac crests. A tumor around the foramen magnum was suspected, however plain skull and neck, laminogram of cervical spines, vertebral arteriogram, fractional pneumoencephalogram and myodil myelogram failed to disclose abnormalities. Manometric Queckenstedt test showed a partial block on flexion, with CSF protein of 56 mg/dl. Air myelogram clearly visualized the presence of an intramedullary tumor at the level of the medullo-spinal junction. Subtotal removal of the intramedullary tumor at C1 was performed, which proved to be a schwannoma histologically. 14 such cases are reported in the literature and summarized on Table I, including our case. Clinical features of tumors around the foramen magnum are fairly complexed, and some radiological examinations might not be conclusive. It is stressed that air myelogram is extremely valuable in the diagnosis of lesions around the foramen magnum.
 ...
PMID:[A case of intramedullary spinal schwanoma (author's transl)]. 98 97

Authors performed in two patients a macroscopically complete exeresis of a panspinal ependymoma. The first case concerns a 27 years old woman, submitted to surgery in 1971, soon after a delivery, who exhibited a tumor in all points identical to the one described by G. Horrax an D. Henderson (1939). The second case concerns a male subject submitted to surgery in May 1973 because of a lesion extending from C2 to L2 and corresponding to a dorsal fleshy ependymoma, surrounded by two voluminous pseudosyringomyelic cysts, with respectively cervical and dorsal-lumbar localization. Such cases rare, with sometimes difficult clinical and roentgenologic diagnosis, raise before all problems of surgical tactics. We are dealing here with benign ependymomas, few favourable to roentgentherapy. Their management is surgical, i.e. complete exeresis. The few common extent of some of these tumors to the totality of the spinal cord does not modify in any manner such a principle. The same may be said of some etiologic circumstances, such as pregnancy, that often enough constitute a postponing of diagnosis and mangement detrimental for the patient. Only, the march of the surgical procedure may be object of discussion. The here reported experience lets appear that, when necessary, complete exeresis may be performed in one session under the same conditions and with the same spinal risks than for a less extensive analogous tumor. At long term the problem of spasticity of lower extremities has to be considered. However, in spite of extensive laminectomy, no major deformity of the vertebral column is to be noted.
 ...
PMID:[Pan-spinal ependymoma. Apropos of 2 cases with complete exeresis]. 118 43

From June, 1989 to March, 1991, 24 cases with various spinal disorders were treated in our department using the Dick technique. The results were as follows: In the fresh fracture group (7 cases), all the spine fractures were reduced anatomically: the 2 cases without neurological defects returned to work 3 months after operation; the 3 cases with incomplete paraplegia had rapid neurological recovery; and the 2 cases with complete paraplegia showed no recovery after operation. In the late fracture group (10 cases), traumatic kyphotic curves were partially reduced and back pain was decreased markedly in all: Muscle power was increased significantly in 3 cases; spasticity was remarkably improved in 2 cases; 3 cases obtained complete cure of incontinence; and 4 cases had no significant improvement. In 3 cases with ankylosing spondylitis, the initial average kyphotic curve was 73.3 degrees, while the postoperative average curve was 28.3 degrees. The result of treatment of spinal stenosis due to degenerative spondylolisthesis (1 case) was good; slipping vertebrae were stabilized and fused with the Dick system after thorough decompression. In 1 tumor and 2 Tb-spine cases, the patients recovered and were ambulatory soon after operation.
 ...
PMID:The application of Dick instrumentation in spine surgery. 142 57

A case of spinal dumbbell shaped melanotic schwannoma was reported. A 58-year-old housewife had a 3-months history of progressive gait disturbance. She also complained of mild backache and numbness in both legs. Her family history was not remarkable. When examined on admission, October 10, 1982, mild weakness of both legs with spasticity and sensory impairment below the level of T10 dermatome without sacral sparing were evident. Her deep tendon reflexes were hyperactive on both sides and plantar responses were extensor bilaterally. Sphincteric disturbance was not significant. The function of her cranial nerves was intact. She had neither cutaneous lesions, abdominal mass nor organomegaly. Thoracic plain X-rays revealed erosion of the right side vertebral body and pedicle of the 10th thoracic vertebra. Myelography disclosed a complete block at the same level by an epidural mass. On CT-myelogram, soft tissue density mass compressing the thoracic cord was apparent in the right epidural space of the spinal canal which extended to the paravertebral region through the right intervertebral foramen. Partial destruction of the body and the right side pedicle was easily recognized. Laminectomy from T9 to T11 exposed a large extradural mass which was encapsulated, elastic soft and pigmented in nature. The tumor was dumbbell shaped and extended to the right paravertebral region through the intervertebral foramen. Costotransversectomy was performed to excise the mass entirely. Following the total removal of the tumor, internal fixation was carried out by means of Harrington instrumentation with methylmethacrylate.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:[Spinal melanotic schwannoma: report of a case]. 306 Jul 51

In order to evaluate physiological significance of F-wave in the diagnosis of spasticity, 10 patients with intracranial mass lesion who did not show clinically lateralizing evidence especially in DTRs were examined and the data were compared with the results obtained from 10 other normal subjects. F-wave was recorded from thenar muscle with supramaximal stimulation to the median nerve at wrist. Latency and amplitude of F-wave failed to show any significant difference in patients compared with normal subjects both on affected sides, however, frequency of F-wave was found to be significantly higher on affected side except for 2 cases who had a mass lesion in occipital lobe in one case and the other was in the state of diaschisis due to recent hemorrhage in the parietal tumor. The site of lesion was carefully determined with CT scan and it was concluded that the F-wave could be detected quite in early stage of intracerebral mass lesion if the process had affected to internal capsule or cerebral peduncle under indirect mass effect such as cerebral edema. On the contrary, it was interesting to note that the mass with no affection to the premotor cortex likely showed higher frequency of F-wave on the ipsi-lateral side of lesion. As the conclusion, F-wave was found to have advantage in the diagnosis of spasticity in the early stage of illness and more accurate information on spasticity could be obtained compared with T or H-wave.
 ...
PMID:[Physiologic significance of F wave in spastic paralysis in the diseases of the cerebral hemisphere]. 631 23

Neoplastic angioendotheliosis (NA) of the CNS is usually characterized by systemic vascular disease and a rapidly fatal course. We report a 52-year-old woman with dementia, spasticity, and sensory deficits developing insidiously over a year. Diagnostic findings included small CT lucencies in the brain and angiographic irregularities of medium-sized arteries (resembling cerebral arteritis). Brain biopsy revealed numerous small infarcts as well as pleomorphic, highly malignant tumor cells within cerebral meningeal vessels. Without treatment, she experienced only slight increase of dementia before death from pneumonia. At autopsy, there was almost complete regression of the intravascular cerebral tumor. The clinical course was unusual for the length of illness and the radiographic picture of cerebral vasculitis. Clinical features often present with NA--such as strokelike events, elevated sedimentation rate, renal impairment, and fever--were notably absent.
 ...
PMID:Neoplastic angioendotheliosis: a case with spontaneous regression and radiographic appearance of cerebral arteritis. 668 58

A total of 116 cases of intestinal eosinophilic granuloma caused by Angiostrongylus costaricensis in children were studied during the 10-year period 1966-1975 at Costa Rica's National Children's Hospital. A similar prevalence of cases was observed each year. The disease was twice as frequent in males as in females, and occurred predominantly in children 6-13 years old (53% of cases). The clinical symptoms were those of "acute abdomen," with pain at the right iliac fossa, pain on palpation, a tumor-like mass, abdominal rigidity, and painful rectal examination. The picture was, nevertheless, mild to moderate. Fever was classified as mild. Leukocytosis with predominance of eosinophils was seen in most cases. Radiology revealed rigidity and spasticity of the intestinal wall with poor filling on medium contrast. Thiabendazole and diethylcarbamazine were given, but there was no evidence that they were effective. Surgery was performed in 90 cases--appendectomy, ileo-colonic resection, or hemicolectomy. The main localizations of the lesions were the cecum, ascending colon, appendix, and small intestine. The pathologic findings in tissues were edema and rigidity of the intestinal wall, yellow granulations in the subsera and, in the later years of the study, eggs, larvae, or the parasite itself. Two of the patients died; the remainder recovered.
 ...
PMID:Clinical abdominal angiostrongylosis. A study of 116 children with intestinal eosinophilic granuloma caused by Angiostrongylus costaricensis. 740 4

Four patients with haemangioendothelioma of the spine which was treated surgically are presented. Two were male and two female, mean age 30 years (range 5-60). All tumours were sited in the thoracic spine between T5 and T10; three were primary and one metastatic from a hepatic haemangioendothelioma. Each patient had a significant neurological deficit at presentation; three were paraplegic. A diagnosis of vertebral neoplastic disease was suggested on plain radiographs, and in three cases this was supported by computed tomography or magnetic resonance imaging. Two patients underwent anterior decompression and posterior instrumented stabilisation, one anterior decompression alone and one posterior decompression followed by tumour vessel embolisation and then anterior decompression. Intra-operative blood loss was a significant feature despite the use of hypotensive anaesthetic techniques and local haemostatic agents. Three of the tumours were tested for Factor VIII (a tumour for vascular tumours), and all proved positive. In these, sufficient histological material was available to grade the tumours according to the classification of Campanacci et al. [1]. All were grade II. Three patients recovered completely from paraglegia; one had residual mild spasticity which required the use of a walking aid. The mean improvement in Frankel grade was 2.5 (range 1-4). In two the tumour recurred outside the spine within 18 months; one had subsequently died. The presentation, investigation and results of surgery for haemangioendothelioma of the spine are presented. Particular attention is drawn to the neurological status at presentation, the effect of pre-operative tumour embolisation and the dramatic recovery that can be achieved in these patients following surgery.
 ...
PMID:Surgical management of haemangioendothelioma of the spine. 755 54

Epidural spinal cord stimulation was performed in a patient complaining of spasticity with intractable pain after operation of metastatic spinal tumor. The end of the electrode was positioned along a line extending down the 11th vertebral body. Following confirmation of satisfactory effects during 10 days of trial stimulation, the electrode was permanently implanted. Excellent pain relief (80%) and significant relaxation of spasticity resulted in a medication free period with improved daily activities. Although the treatment of this case resulted in clinical success, the problem concerning the payment of the transmitter remained. We hope that the health insurance system will extend its indications to cover medical fees for the transmitter.
 ...
PMID:[A case of spasticity following spinal cord injury improved by epidural spinal cord stimulation]. 760 6


1 2 3 4 5 6 Next >>