Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0026838 (spasticity)
 6,471 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Drug-associated hyperthermic syndromes include the serotonin syndrome, neuroleptic malignant syndrome, neuroleptic-induced catatonia, anticholinergic syndrome, sympatomimetic syndrome and malignant hyperthermia. Discontinuation of medication is a sufficient treatment for mild serotonin syndrome. In a more severe situation the patient's spasticity and hyperthermia are treated with drugs. In neuroleptic malignant syndrome discontinuation of medication does not suffice, but the patient needs active therapy. Many of the drugs causing these syndromes are common in clinical use. Starting an effective treatment early enough is more important than a precise diagnosis.
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PMID:[Drug-associated hyperthermic syndromes]. 2447 Dec 6

Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal complication resulting from neuroleptic drug therapy. Presentation of NMS can vary, and diagnosis relies primarily upon medical history and symptomatology. Due to the potential delay in diagnosis, emergency physicians should remain vigilant in recognizing the symptoms of NMS and be prepared to initiate immediate treatment following diagnosis. Dantrolene, which has been used for spasticity and malignant hyperthermia, has been reported as a potential treatment for NMS and led to off-label use for NMS. We report two cases of NMS induced by antipsychotic monotherapy for which dantrolene was administered.
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PMID:Emergent Treatment of Neuroleptic Malignant Syndrome Induced by Antipsychotic Monotherapy Using Dantrolene. 3077 57


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