Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0026838 (spasticity)
 6,471 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 17-year-old boy presented with a 1-year history of progressive gait difficulties and slowing of fine hand movements. On neurological examination there was tetraspasticity, bilateral pes equinovarus and a decreased position sense in the feet. CT and MRI scan of the cervical spine demonstrated a spina bifida occulta of C1, an extensive intradural lipoma from the foramen magnum to C4 with a small intramedullary portion at C3, and a distal syringomyelia reaching down to D12. After excision of the extramedullary portion of the lipoma, there was a marked improvement of the gait and a reduction of the spasticity.
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PMID:Extensive cervical intradural and intramedullary lipoma and spina bifida occulta of C1: a case report. 845 14

Neuroimaging studies for persons in the National Collaborative Chicago-Based Congenital Toxoplasmosis Study (NCCCTS) with symptoms and signs referable to the spinal cord were reviewed. Three infants had symptomatic spinal cord lesions, another infant a Chiari malformation, and another infant a symptomatic peri-spinal cord lipoma. One patient had an unusual history of prolonged spinal cord symptoms presenting in middle age. Neuroimaging was used to establish her diagnosis and response to treatment. This 43 year-old woman with congenital toxoplasmosis developed progressive leg spasticity, weakness, numbness, difficulty walking, and decreased visual acuity and color vision without documented re-activation of her chorioretinal disease. At 52 years of age, spinal cord lesions in locations correlating with her symptoms and optic atrophy were diagnosed with 3 Tesla MRI scan. Treatment with pyrimethamine and sulfadiazine decreased her neurologic symptoms, improved her neurologic examination, and resolved her enhancing spinal cord lesions seen on MRI.
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PMID:Spinal Cord Lesions in Congenital Toxoplasmosis Demonstrated with Neuroimaging, Including Their Successful Treatment in an Adult. 2348 48

A case of a 32-year-old male patient is reported. He was admitted with complaints of burning dysesthesias over his right upper limb and chest and spasticity in the legs. Investigations revealed a long segment intramedullary tumor, image intensity of which matched lipoma. Imaging of craniovertebral junction suggested atlantoaxial "facetal" instability. Atlantoaxial fixation was done, and the intramedullary lipoma was not physically handled or manipulated during surgery. The patient improved in his neurological condition following surgery. The follow-up imaging showed that the intramedullary lipoma reduced significantly in its dimensions. From the case, it appears that the presence of "fat" and "water" in the intramedullary location might have similar pathogenesis.
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PMID:Central atlantoaxial instability as a cause of syringomyelia mimic intramedullary lipoma. 3290 52