Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026838 (
spasticity
)
6,471
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Baclofen is a centrally acting gamma-ammino butyric acid agonist that is used like muscular relaxant in disorders with
spasticity
and intractable hiccups. Although encouraging and safe results were provided 5 mg/day in hemodialysis patients, his pharmacokinetic and pharmacodinamic properties are not well known in
end stage renal disease
. We present here the case of a hemodialysis patient with intractable hiccups who developed baclofen-associated encephalopathy with this recommended dose.
...
PMID:[Baclofen-associated encephalopathy in a hemodialysis patient with hiccups]. 1705 62
Baclofen is a highly used centrally acting GABA agonist that continues to be an effective therapy for
spasticity
and chronic hiccups. The renally dependent excretion determines the circulating concentrations and guides effective dosing to decrease adverse reactions. Caution should be considered in administering baclofen to patients with decreased renal function. We present a patient with
end stage renal disease
on hemodialysis with recent baclofen ingestion who presented with toxic encephalopathy that was resolved with additional dialysis sessions.
...
PMID:Baclofen-Induced Encephalopathy in End Stage Renal Disease. 2629 12
