Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026838 (spasticity)
 6,471 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A chondral growth/force response curve predicts how intact hyaline cartilage plates grow in vivo under typical peak mechanical unit loads and gradients thereof in healthy immature mammals. Growth under tension would increase as tension rises from zero to a level that damages the tissue. Under compression, growth would increase as the load rises from zero to a level at which growth becomes maximal (the growth-ascending limb of the curve). Further increases in compression loads retard growth and large enough increases can stop it entirely (the growth-descending limb of the curve). For equal changes in loads, the smallest growth change would occur under tension; the largest change would occur on the growth-descending part of the curve. Under zero load a respectable "baseline growth" still occurs. Those effects are superimposed on inherent differences in growth potential of different chondral plates, differences that are determined partly in utero and by the genome. The curve's features can explain many anatomical facts, including the ball-and-socket ankle, joint alignment in the valgus-varus sense, hip dislocations in spasticity, different epiphyseal heights, short bones in paralysed limbs, long bone overgrowth after fractures, why some joint surfaces remain concave and others convex throughout growth, and why some growth plates are domed instead of flat. The above phenomena can be expressed mathematically, and a phenomenologic basic logical framework for doing that is suggested.
Anat Rec 1990 Apr
PMID:Skeletal structural adaptations to mechanical usage (SATMU): 3. The hyaline cartilage modeling problem. 169 1

Recombinant 8 syndrome, also known as San Luis Valley syndrome, is a rare but important cause for developmental delay and chronic illness noted among individuals of Hispanic ancestry that occurs with greater reported frequency in the Southwest United States. The recombinant chromosome is rec(8)dup(8q)inv(8)(p23.1q22.1) and in all known cases is derived by a parental pericentric inversion, inv(8)(p23.1q22.1). To test our hypothesis that modern medical management strategies may alter the outcome of patients with recombinant 8 syndrome in regard to mortality, morbidity, and neurodevelopmental outcomes, we sought to update the natural history of recombinant 8 syndrome by completing a thorough medical and psychological assessment of affected individuals. Twelve affected individuals, ranging from 2 to 21 years of age, were recruited with IRB approval. Our patients scored on in the mild to severe cognitive functioning level (range 30-70), with surprising preservation in the social/adaptive arenas. Most patients responded well to heart surgery and developmental outcomes were in proportion to cardiac status. Orthopedic surgery to ameliorate effects of spasticity can be complicated by long recovery times and decreased ability to ambulate. Our findings do not support additional morbidly during cardiac repair. Taken together, our findings support a consistent phenotype with improved survival in comparison to previously published studies. Efforts to encourage learning and developmental progress should not be withheld as quality of life for many of these individuals is considered good by their families and medical providers.
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PMID:Revisiting recombinant 8 syndrome. 2173 94