Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0026837 (muscle rigidity)
 1,077 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 42-year-old woman with myotonic dystrophy underwent general anesthesia twice. In the first operation, muscle rigidity was recognized when the patient was placed on lithotomy position under anesthesia with thiopental and nitrous oxide. In the second operation, rigidity was not observed under vecuronium, sevoflurane-nitrous oxide anesthesia. Neuromuscular monitoring of this patient did not show any difference of neuromuscular blockade with vecuronium compared with other 9 normal patients. We conclude that vecuronium and sevoflurane can be used safely in a patient with myotonic dystrophy under neuromuscular monitoring.
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PMID:[General anesthesia conducted twice in myotonic dystrophy]. 809 79

A 42-year-old man came to our emergency room hyperthermic (oral temperature, 42.4 degrees C), diaphoretic, and delirious. Other findings included labile blood pressure, sinus tachycardia (heart rate, 138/min), tachypnea (respiratory rate 34/min), muscle rigidity, and incontinence. Two days earlier, he had gone to a local clinic with complaints of abdominal pain, nausea, and vomiting. Promethazine was prescribed, and this was the patient's only medication on admission. Laboratory studies showed leukocytosis, hypernatremia, metabolic acidosis, elevated creatinine phosphokinase level, elevated transaminase levels, azotemia, hyperkalemia, hyperphosphatemia, hypocalcemia, and myoglobulinuria. The clinical and laboratory findings were characteristic of the neuroleptic malignant syndrome, with promethazine as the offending agent.
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PMID:Neuroleptic malignant syndrome due to promethazine. 1054 78