Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026837 (muscle rigidity)
 1,077 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Previous studies in isolated limbs using crystalloid perfusion solutions have shown that control of the initial reperfusion reduces postischaemic complications. However, no experimental study has been undertaken to evaluate the concept of controlled limb reperfusion experimentally in an in vivo blood-perfused model and to assess the local as well as systemic effects of normal blood reperfusion and controlled limb reperfusion. Of 20 pigs undergoing preparation of the infrarenal aorta and iliac arteries, six were observed for 7.5 h and served as controls; 14 others underwent 6 h of complete infrarenal occlusion. Thereafter, embolectomy was simulated in eight pigs by removing the aortic clamp and establishing normal blood reperfusion at systemic pressure. In six other pigs, the composition of the reperfusate and the conditions of reperfusion were controlled during the first 30 min, followed by normal blood reperfusion. Some 6 h of infrarenal aortic occlusion leads to a severe decrease in high-energy phosphates and muscle temperature, together with a slight increase in creatine kinase and potassium in the systemic circulation. Normal blood reperfusion resulted in severe reperfusion injury: massive oedema developed, the tissue showed a marked decrease in oxygen consumption, glucose consumption, tissue ATP, total adenine nucleotides, muscle pH and total calcium in the femoral vein. Furthermore, a massive increase was seen in plasma creatine kinase concentration and potassium, together with the development of muscle rigidity. In sharp contrast, initial treatment of the ischaemic skeletal muscle by controlled limb reperfusion resulted in normal water content, oxygen consumption, glucose consumption, flow and muscle rigidity. Furthermore, controlled limb reperfusion resulted in higher total adenine nucleotides content, less tissue acidosis, markedly reduced creatine kinase release, and potassium release as compared with that of normal blood reperfusion. This study shows that 6 h of acute infrarenal aortic occlusion will result in severe reperfusion injury (postischaemic syndrome) if normal blood at systemic pressure is given in the initial reperfusion phase. In contrast, initial treatment of the ischaemic skeletal muscle by controlled limb reperfusion reduces the metabolic, functional and biochemical alterations.
Cardiovasc Surg 1994 Dec
PMID:Reperfusion injury in skeletal muscle: controlled limb reperfusion reduces local and systemic complications after prolonged ischaemia. 785 92

The incidence of lower extremity ischemia secondary to acute aortic dissection is relatively low, however, the presenting symptoms are variable in term of severity. We report here in two cases of such circumstances who were successively differently treated. Case one was a 60 years old male presented with severe left leg pain. Even after the initiation of cardiopulmonary bypass, the leg ischemia did not improve, therefore selective leg perfusion was additionally performed through direct left femoral artery cannulation. The surgery toward dissection was completed by mean of simultaneous graft replacement of ascending aorta and aortic arch. The leg ischemia after the aortic procedure however had persisted, femorofemoral bypass was created to relieve the mal-perfusion. Case two was a 37 years old male admitted with severe left leg pain associated with sensory-motor nerve dysfunction with muscle rigidity. In this particular patient, femoro-femoral bypass was firstly reconstructed as the mean of leg salvage procedure. After we learned there was no serious reperfusion symptom manifested, we performed radical surgery toward the aorta. We believe that the decision making of surgical treatment for acute type A dissection complicated with the presence of lower extremity ischemia is based on the severeness of mal-perfusion.
Jpn J Thorac Cardiovasc Surg 1998 Oct
PMID:[Acute type A aortic dissection with leg ischemia]. 984 78

Evaluation of: Meaney A, Ceballos G, Asbun J et al. The Vytorin on Carotid Intima-Media Thickness and Overall Arterial Rigidity (VYCTOR) Study. J. Clin. Pharmacol. 49(7), 838-847 (2009). The Vytorin on Carotid-Media Thickness and Overall Arterial Rigidity (VYCTOR) study was designed to assess the clinical effect of three lipid-lowering treatment regimens on carotid intima-media thickness. The study was designed to analyze 90 high-risk patients who were initially randomly allocated to three treatment groups; pravastatin 40 mg/day (group A), simvastatin 40 mg/day (group B), and simvastatin 20 mg/day plus ezetimibe 10 mg/day (group C) as initial therapy. The therapeutic goals were less than 100 mg/dl LDL-cholesterol in subjects with coronary disease or less than 70 mg/dl in high-risk subjects. Titration of the pharmacologic doses was allowed if therapeutic goals were not achieved. Subjects randomized to receive pravastatin (group A) were allowed to add 10 mg of ezetimibe to the baseline therapy. Patients in group B were titrated to 80 mg of simvastatin. Group C received simvastatin 40 mg/day and ezetimibe 10 mg/day. The primary end point of the trial was pharmacologic alteration of intima-media thickness over a 12-month trial period. Several secondary end points were also analyzed, including changes in LDL-cholesterol and high-sensitivity C-reactive protein. Additionally, alteration of arterial stiffness was also analyzed. Significant reductions in carotid intimal thickness and LDL-cholesterol levels (60%) were acheived with aggressive lipid-lowering therapy. The VYCTOR study did not reveal significant differences in C-reactive protein, HDL, triglycerides, blood pressure or BMI between groups.
Expert Rev Cardiovasc Ther 2009 Sep
PMID:The Vytorin on Carotid-Media Thickness and Overall Arterial Rigidity (VYCTOR) study. 1944 79