Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026837 (
muscle rigidity
)
1,077
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The history, symptoms, diagnosis and treatment of phencyclidine hydrochloride (
PCP
) intoxication, the pharmacology of
PCP
and the detection, identification and analysis of
PCP
are reviewed. The history of
PCP
from its synthesis in the early 1950s to the present is discussed. Intoxication with low to moderate doses of
PCP
resembles an acute, confusing state. High doses may cause serious neurological and cardiovascular complications and the patient is often comatose for several days. Treatment involves supportive psychological and medical measures, and acidification of the urine may further increase
PCP
clearance. The metabolism of
PCP
involves primarily hydroxylation followed by conjugation and elimination in the urine. Analysis can be accomplished by a number of instrumental methods, and several commercial test kits based on antigen-antibody interactions are available.
PCP
's effect on human performance and behaviour is due to its ability to alter the perception of reality in the user.
PCP
causes a range of effects that include hallucinations, delirium, disorientation, agitation,
muscle rigidity
, ataxia, nystagmus, seizures, and stupor.
PCP
has stimulant, depressant, hallucinogenic and analgesic effects. Which of these will be most pronounced is unpredictable and depends on the user's personality, psychological state and the environment of use. The impairment can manifest itself as over-aggressive or reckless driving behavior, or may mimic depressant effects due to
PCP
's anesthetic and depressant effect.
...
PMID:Phencyclidine - Effects on Human Performance and Behavior. 2625 94
