Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0026827 (hypotonia)
 5,860 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Notwithstanding the legalization of abortions because of social indications, acute renal insufficiency after septic and criminal abortions still constitutes a high percentage of cases to be treated in the dialysis department. This article reports on 26 cases of acute renal insufficiency after criminal or septic abortions and on their complications. All cases were characterized by a marked hyperthermia for 2-4 days, marked hyperleucocystosis, early onset of anemia with intravascualr hemolysis and protracted hypotonia. Early introduction of exchange blood transfusion decreased the signs of anemia and stopped the development of intravascular hemolysis, but did not change in any significant way the course of acute renal insufficiency. In the study presented here, 4 women deceased within 2-3 hours after admission; in conclusion, treatment was unsuccessful in 16 cases, and lethal exit occurred in 10 cases. Treatment was successful in 5 out of 14 cases after criminal abortion, and in 11 cases after septic abortion. Better results were observed in those patients where the proper diuretic therapy and exchange blood transfusions or dialysis were undertaken in the first 3 days after abortion. That is why it is recommended to transfer patients with acute renal insufficiency subsequent to criminal or septic abortion to the dialysis department in the first 24 to 48 hours after abortion. (Author's modified)
Ginekol Pol 1979 Nov
PMID:[Acute renal insufficiency after criminal and septic abortion]. 54 51

Hemiplegic migraine was observed in a boy aged 16 years. The family history was unquestionable and the duration of hemiplegia was prolonged. Carotid angiography after regression of clinical signs showed a particularly profuse passage of the contrast to the contralateral side and to the area of vascularization of the basilar artery. It is supposed that particularly favourable connections existed in this case in the arterial vascular bed of the brain, with possible hypotonia of the arterial walls in this area.
Neurol Neurochir Pol
PMID:[Case of hemiphlegic migraine with atypical angiographic findings]. 71 33

In a girl from a family with muscular hypotonia, hypoglycaemia, lactic acidosis and delayed development the analysis of organic acids in urine suggested a defect in leucine metabolism--3-hydroxy-3-methylglutaric aciduria. A good therapeutic effect was obtained with low-protein diet.
Mater Med Pol
PMID:A case of organic aciduria--suspected 3-hydroxy-3-methylglutaric aciduria. 172 25

A case of Leigh disease in a 3-year-old girl is reported. The child had regression of the psychomotor development, muscular hypotonia, weak tendinous reflexes, opsoclonus, tremor of the whole body, hypertrichosis, autonomic system disturbances. Laboratory investigations demonstrated raised serum lactic acid level. Postmortem histological examination of the brain confirmed the diagnosis of Leigh disease established before death.
Neurol Neurochir Pol
PMID:[Leigh disease in a 3-year-old girl]. 180 61

The purpose of the study was differential diagnosis of lactic acidosis in 44 children aged from 2 weeks to 4 years. In all of them the lactate level in repeated determinations exceeded 27 mg/100 ml. From the point of view of clinical manifestations the children were divided into three groups: 26 with hepatomegaly and hypoglycaemia (I), 6 with ataxia and retardation of somatic development (II), 12 with mental retardation and muscular hypotonia (III). Together with basic biochemical studies other tests were done, if necessary, including glucose and alanine loading, lactate determination in cerebrospinal fluid, analysis of urinary organic acids by the GC-MS method, morphological examinations of muscle biopsy material, enzymatic determinations in liver biopsy material. In group I glycogenosis was suspected and its type was finally established after biochemical and enzymatic tests (types I, Ib, III, VI, VIa, XI). In one case fructose-1,6-diphosphatase deficiency was suspected. In group II the clinical manifestations resembled Leigh's syndrome. The tests demonstrated an inhibition of glucose formation from alanine, and lactate level in the cerebrospinal fluid was evidently raised above that in the serum. Gasometric index showed the presence of respiratory alkalosis with metabolic compensation rather than primary lactate acidosis. In group III, with considerable clinical variety of signs, in only nine out of 12 children the cause of lactate acidosis could have been established (pathological changes of mitochondria in 4 cases, secondary increase of lactate without pathogenetic importance in 4, and 3-hydroxy-3-methylglutaric acidosis in 1 case. In conclusion it is thought that this combination of diagnostic methods is useful in differential diagnosis of congenital lactate acidosis in children.
Mater Med Pol
PMID:Congenital lactic acidosis in children--differential diagnosis in 44 cases. 184 18

Interleukin-2 is a lymphokine with documented antineoplastic influence, with not completely understood mechanism of action. The case of 46-years old patient with relapsed metastatic malignant melanoma treated with constant-infusion of rIL-2 is described. 9-month remission was achieved. During the course of treatment a lot of side effects including flu-like symptoms, hypotonia, anemia and thrombocytopenia, and also many biochemical disturbances were observed.
Pol Arch Med Wewn 1990 Nov
PMID:[Interleukin-2 in the treatment of malignant melanoma. A case report]. 207 26

The value of vasodilatatory treatment of pulmonary hypertension due to chronic obturative pulmonary disease (c.o.p.d.) is still controversial. However in patients with c.o.p.d. causal treatment as well as chronic domestic oxygen therapy have a wide range of limitations. Among vasodilator alpha-1 blockers show less vasodilator-related adverse effects, and as known from acute trials they exert a potent effect on pulmonary circulation in patients with pulmonary hypertension and c.o.p.d. Prazosin was studied in 11 patients (10 men, 1 women) aged 63 +/- 7 years with advanced c.o.p.d. (FVC 1.8 +/- 0.41, FEV1 0.99 +/- 0.55 l) (s) after their clinical stabilisation. In 4 of them prazosin was added to the maintenance dose of diuretics and digitalis. Subjective status, NYHA functional class, spirometric (FVC, FEV1) and gaseous (PaO2, PCO2) parameters, weight, systemic blood pressure, and heart rate were noted. During Swan-Ganz catheterization mean pulmonary artery pressure (MPAP), right ventricular end-diastolic pressure (RVEDP), pulmonary wedge pressure (PCWP), cardiac output (CO), systemic (SVR) and pulmonary (PVR) vascular resistance were measured. The acute trial with 1 mg prazosin taken orally was followed by 2- and 6-week of 3 mg prazosin treatment assessment. After a single dose of 1 mg prazosin there was a significant decrease in MPAP from 36 +/- 9 to 28 +/- 10 (p = 0.001) and 44% decrease in RVEDP (p = 0.05). CO increased by 16% (p = 0.01). The fall in PVR (30%, p = 0.01) exceeded that in SVR (17%, NS). No adverse effects were observed. During 2-week 3 mg a day prazosin therapy 2 patients were excluded following dyspnea and systemic hypotonia.(ABSTRACT TRUNCATED AT 250 WORDS)
Kardiol Pol 1990
PMID:[Clinical and hemodynamic evaluation of 6-week treatment of pulmonary hypertension in chronic obstructive lung diseases (COLD) with low dose of prazosin]. 208 1

Acute and subacute autonomic neuropathies are rarely observed disease syndromes. Their symptoms result from the involvement of autonomic cholinergic fibres (cholinergic dys-autonomy) as well as cholinergic and noradrenergic ones (pan-dys-autonomy). The paper presents symptoms of both forms of the disease and methods of their diagnostics. Up-to-date trials of the treatment of orthostatic hypotonia a leading symptom of pan-dys-autonomy, have also been discussed.
Neurol Neurochir Pol
PMID:[Acute and subacute autonomic neuropathy]. 213 31

The case of surgical treatment of a 44-years old female with a double atrio-ventricular accessory pathway and mitral stenosis was described. Fast ventricular rates due to conduction through the accessory pathways during atrial fibrillation in course of mitral stenosis caused severe heart failure, occasionally with deep hypotonia. Combined treatment with prajmaline and propafenone blocked conduction through accessory pathways. The ventricular rate slowed from approx. 200/min to 150/min. Addition of digoxin slowed the ventricular rate down to approx 80-100/min. There were no signs of preexcitation. Treatment with diuretics and vasodilators was continued. The state of patient improved. Echocardiographic and hemodynamic evaluation revealed: mitral stenosis (orifice - 75 mm2) with moderate regurgitation, small aortic and tricuspid regurgitation. The coronary arteries were normal. On the base of the ECG recordings during atrial fibrillation both accessory pathways were localized on lateral and posterior parts of the left free wall. The patient was operated on. Both atrio-ventricular by-pass tracts were dissected using Sealy's method in Cox modification and then mitral valve prosthesis Medtronic-Hall 27 mm was implanted. Prajmaline and propafenone were discontinued and preexcitation did not recovered. The sinus rhythm was restored by electroversion. The patient had no overt heart failure on discharge from the Institute.
Kardiol Pol 1990 Jan
PMID:[Dissection of the accessory conduction pathways with simultaneous mitral valve surgery]. 227 77

The authors describe the clinical manifestations in 200 cases of cerebellar vascular lesions confirmed on autopsy. The clinical symptoms and signs included very little typical cerebellar signs, the most frequently observed changes were: gradually increasing coma, muscular hypotonia, sluggish reflexes, ocular signs. The diagnosis was made even more difficult by the presence of additional pyramidal signs. The causes of diagnostic errors emphasized by the authors are: 1) an erroneous conviction of doctors that vascular cerebellar lesions must be associated with cerebellar signs, 2) difficulty in carrying out whole neurological examination since gait and posture cannot be observed in these bedridden patients, 3) frequently cerebellar focal lesions are associated with focal lesions in other brain structures (brainstem and cerebral hemispheres) with consequent superimposition of various symptom complexes, 4) presence of profound coma which not infrequently blurs many signs. Nevertheless, the authors could have established the clinical diagnosis of vascular cerebellar lesions in one-third of these cases.
Neurol Neurochir Pol 1982
PMID:[Diagnostic difficulties in cases of vasogenic lesions in the cerebellum]. 715 84


1 2 3 Next >>