Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026827 (
hypotonia
)
5,860
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A 9 month old boy with acute lymphoblastic leukaemia developed signs compatible with an extrapyramidal lesion (rough tremor of the skeletal muscles, more pronounced on the left side, with
hypotonia
and reduced cutaneous reflexes). This problem started 4 days after the second weekly course of chemotherapy with
Vincristine
(1.5 mg/m2) and Adriamycin (25 mg/m2) and lasted with varying intensity until death 4 weeks later. Toxicity of either drug (or both) to the central nervous system was invoked as a likely explanation and
Vincristine
was considered to be more likely condidate for that effect.
...
PMID:A Parkinson-like syndrome as side effect of chemotherapy with vincristine and adriamycin in a child with acute leukaemia. 29 57
