Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0026827 (hypotonia)
 5,860 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

After the stereotactic treatment of patients with Parkinson's disease, a correlative study between the site of the deep subcortical lesions and subsequent cerebellar signs (dysmetria and hypotonia) was made. Cerebellar signs appeared in 27 cases (40.8%) of subthalamotomy and in 3 cases (8.6%) of VIM thalamotomy 2 weeks after an operation. The appearance of these signs after an operation was independent from the operative effect on tremor. Thus, we concluded that VIM thalamotomy might be better than subthalamotomy for the relief of tremor in Parkinson's disease.
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PMID:Slight cerebellar signs in stereotactic thalamotomy and subthalamotomy for parkinsonism. 80 61

Electromyographic and mechanographic investigations in patients with muscular hypotonia, which is, for instance, a side-effect after stereotactic treatment of tremor syndromes, permit the presumption that in this sensomotor open-loop situation the decreased muscular resistance to stretching during isometric contraction (initial stiffness) is caused by changes of muscular innervation pattern. Probably, the innervation pattern during tonic activity is changed by a shift of a more tonic motoneurone behaviour to motoneurone activities with predominantly phasic characteristics. In 17 controls and 4 patients with muscular hypotonia caused by stereotactic lesions of VIM area (treatment of tremor syndromes) the EMG of right and left side forearm flexors (especially the activity of the M. biceps brachii) was investigated by a sophisticated, topographically oriented 16-channel-surface-EMG-technique ("EMG-Mapping") during slight isometric contraction. EMG-Maps of forearm flexors (especially of M. biceps brachii) in patients with centrally evoked muscular hypotonia demonstrate that in these open-loop conditions the motor control is changed. For this the reason could be a shift of the activated motor units from a predominantly static to a more phasic functional behaviour. The latest results on muscular activation processes in cats support this presumption.
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PMID:[Control of isometric muscle contraction in muscle hypotonia of central origin: EMG mapping analysis]. 148 21