Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026827 (hypotonia)
 5,860 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Report on 22 children whose esophagus was radiologically examined under maximum hypotonia, using i.v. Buscopan in a dose of 1 mg/kg body weight (highest 50 mg). The main indication are varices of the esophagus which can be shown much better than with conventional techniques. But also small axial hiatus herniae and esophageal stenoses are better shown.
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PMID:[Hypotonic examination of esophagus in pediatric radiology (author's transl)]. 121 55

Forty-seven rats were cannulated permanently in either the globus pallidus or neostriatum and subsequently injected with carbachol, scopolamine, or carbachol plus scopolamine. The injection of carbachol (1 mug) into the globus pallidus produced transient hyperkinetic phasic dyskinesias (84%) followed in some cases by ipsilateral circling (47%) associated with hypertonic contralateral hind limbs. This condition progressed in some rats to a cataleptic state (42%). The injection of scopolamine (50 mug) or scopolamine (50mug) plus carbachol (1 mug) into the pallidum produced ipsilateral circling associated with hypotonia of the contralateral hind limb in a few rats. No hyperkinetic dyskinesias nor catalepsy were produced by these injections. The injection of carbachol (1 mug) into the neostriatum produced hyperkinetic dyskinesias (86%) of long duration, minimal circling (both directions) (10%), and catalepsy (29%). These effects were blocked by the addition of 50 mug of scopolamine to the carbachol injection. Scopolamine (50-100 mug) alone produced no effects after injection into the caudate/putamen. Saline injections in the neostriatum or globus pallidus produced no motor disturbance.
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PMID:Motor effects of cholinergic stimulation of the globus pallidus in rats. 124 90