Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026827 (hypotonia)
 5,860 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The system proteinases-inhibitors and renin were studied in 105 acute pneumonia (AP) patients, the blood of whom was examined for concentrations of elastase, acid proteases (AP), alpha 1-inhibitor of proteases (alpha 1-IP), alpha 2-macroglobulin (alpha 2-MG) and active or inactive, total renin (TR). A separate group included 18 AP cases complicated by infective toxic shock (ITS). An imbalance was proved in the system proteinases-inhibitors with dominance of the inhibitory potential. In a "cold" variant of ITS proteolytic blood activity rose while the inhibitory capacity fell. Moderate and severe AP forms were associated with lowered blood levels of active R and elevated of inactive R, TR. In arterial hypotonia and ITS these changes were most demonstrable. Elastase, alpha 1-IP, alpha 2-MG and active R, inactive R, TR exhibited close correlation. The discussion covered mechanisms of hemodynamic disturbances in AP with consideration of depressed renin-angiotensin system and imbalance of proteinases and their inhibitors.
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PMID:[Proteinase-inhibitors and renin in the pathogenesis of vascular insufficiency in acute pneumonia]. 161 Dec 68

Infectious diseases belong to the most frequent reasons to seek emergency care. Life-threatening infectious emergencies, which require rapid diagnosis and hospitalisation, are, however, rare. Leading signs and symptoms are high fever combined with rapidly deteriorating general conditions, hypotonia, tachycardia, tachypnea, dyspnea, confusion, headache, or petechia or information about asplenia, immunosuppression or recent travel to the tropics. Life threatening situations, such as suspicion of invasive meningococcal infection or bacterial infection in an asplenic patient, septic-toxic shock, and acute bacterial meningitis with delayed hospitalisation require rapid start of empiric antibiotic therapy in the outpatient practice. In addition, acute infectious emergencies comprise situation for which post exposure prophylaxis is indicated.
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PMID:[Acute infectious emergencies in adults in medical practice]. 1599 31