Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026827 (hypotonia)
 5,860 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The double-contrast method and the compressive technique associated with pharmacological hypotonia of the stomach were compared in 13 cases and found to be equally valuable in the diagnosis of erosive gastritis.
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PMID:Value of the compressive technique associated with pharmacological hypotonia in the diagnosis of erosive gastritis. 66 81

The clinical and morphologic findings of three patients with metabolic acidosis, methylmalonic aciduria, and homocystinuria are presented. The clinical evolution of the patients was similar and was characterized in the first weeks of life by failure to thrive, hypotonia, and lethargy associated with pancytopenia and hepatic dysfunction, eventually progressing to severe respiratory insufficiency and renal failure consistent with a hemolytic-uremic syndrome. The patients died at 40, 45, and 75 days of age. Biochemical analyses and complementation studies revealed a congenital anomaly of vitamin B12 metabolism (cobalamin C disease). Postmortem morphologic findings in all three cases were dominated by a thrombotic microangiopathy of the kidneys and lungs, diffuse hepatic steatosis, and megaloblastic changes in the bone marrow. A severe gastritis with striking cystic dysplastic mucosal changes and total absence of parietal and chief cells was a consistent finding in all three cases, the rest of the gastrointestinal tract appearing essentially normal. Cobalamin C disease is an intracellular defect of cobalamin metabolism with possible recessive inheritance that can result in multiorgan failure early in life, with a thrombotic microangiopathy and unusual changes in the gastric mucosa.
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PMID:A congenital anomaly of vitamin B12 metabolism: a study of three cases. 156 46

The author has examined the possibility of a simultaneous combined examination of liver exosecretion and gastric secretion. A two-channel gastroduodenal tube has been employed. The findings evidence that pentagastrin (6 micrograms/kg) stimulation during the third phase of bile excretion potentiates the effects of cholecystokinetics administered in succession: 33% magnesium sulfate solution (0.5 ml/kg) and, after C bile is obtained (the fifth phase), olive oil (0.4 ml/kg). Continuous aspiration of the gastric juice prevents pancreatic stimulation and permits the measurements of gastric acid production and of the bile debit. In contrast to normal subjects, the 24 examinees with chronic gastritis often presented with an increased volume of the residual B bile (the IVA phase), this evidencing the gall-bladder hypotonia. The 14 patients with inadequate gastric secretion have developed dyskinesias of the gall-bladder and bile ducts twice more often than the rest patients. The suggested method helps detect combined abnormalities of the stomach and the biliary system; it is satisfactorily tolerated by the patients.
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PMID:[Simultaneous study of bile excretion and secretory ability of the stomach using pentagastrin]. 247

The aim of this study was to assess the incidence of oesophageal abnormalities and to determine their nature in patients with retrosternal chest pain and normal coronary angiography with a negative coronary spasm provocation test. Oesophageal manometry was carried out in all cases with or without a spasm provocation (usually alkalosis) test. Forty consecutive patients were studied: 19 men (47.7 +/- 10.0 years) and 21 women (54.7 +/- 7.5 years). A history of gastro-intestinal disorder was obtained in 57 p. 100 of cases (hiatal hernia and/or gastro-oesophageal reflux, biliary lithiasis and/or cholecystectomy, gastritis). Seventeen patients had broad based powerful oesophageal contractions which are an established cause of pain; they were recorded under basal conditions in 5 cases and after a provocation test in 12 cases. Two patients had a megaoesophagus without giant waves. Thirteen patients had manometric signs of reflux (malposition and hypotonia of the lower oesophageal sphincter) of whom 7 had giant waves on provocation. In addition, three patients experienced pain during gastro-oesophageal reflux (1 case) or hypotonia of the lower oesophageal sphincter (2 cases). In all, a very probable oesophageal origin of the chest pain was demonstrated in 22 patients (55 p. 100 of cases).
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PMID:[Esophageal motility in cases of chest pain with normal coronarography]. 343 26

150 patients were examined by the double contrast-technique in drug-induced hypotonia of the stomach. They were examined gastroscopically and at the same time biopsies were taken. Comparison of histological and radiological results was performed. There was found an agreement of 82% in the performance of areae gastricae and the histological diagnosis of chronic gastritis.
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PMID:[The significance of demonstrating areae gastricae at hypotonic double contrast examination of the stomach (author's transl)]. 645 94