Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0026764 (multiple myeloma)
 36,148 document(s) hit in 31,850,051 MEDLINE articles (0.04 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 2297
proteasome 1369
IgA 1108
Mol 1079
proteasome inhibitor 1066
fused 881
lymphoid 871
cytokine 763
non-Hodgkin's lymphoma 686
IL-6 631
interleukin-6 626
CD38 575
heavy chain 523
p53 520
CD138 512
RPMI 505
SP2 491
interferon 450
IgG3 421
IgE 374
CD34 347
M-protein 344
Bcl-2 332
caspase-3 309
albumin 308
ubiquitin 303
endoplasmic reticulum 287
glycoprotein 285
serum albumin 285
HLA 284
She 281
hemoglobin 279
NS-1 274
vascular endothelial growth factor 274
CD19 271
CD4 270
IFN 263
CD8 261
CD20 259
MRI 250
G-CSF 240
granulocyte colony-stimulating factor 239
histone deacetylase 235
serum protein 235
CD56 233
polypeptide 229
Proteasome 226
tumor necrosis factor 224
STAT3 219
cyclin D1 217
SDS 213
AKT 212
mTOR 201
granulocyte 198
Mcl-1 195
histone 193
CD45 189
p21 187
lactate dehydrogenase 177
collagen 177
alkaline phosphatase 176
MYC 170
RANKL 168
C-reactive protein 162
IL-2 158
SCT 158
tyrosine kinase 155
IgH 155
PI3K 155
ERK 155
thymus 154
FDG 152
insulin 150
beta 2-microglobulin 148
CXCR4 147
erythropoietin 145
peroxidase 144
fibronectin 143
CSF 141
MAPK 140
TNF 138
NS1 138
c-myc 134
FISH 134
VEGF 133
ISS 133
p16 132
erythroid 132
ATP 131
gp130 130
osteoprotegerin 128
interleukin 6 128
Fas 126
caspase-8 125
LDH 124
PARP 123
P-glycoprotein 120
GM-CSF 117
FGFR3 117
CD40 116
CLL 115
osteosarcoma 115
syndecan 115
chemokine 114
AML 114
ALL 113
lipopolysaccharide 113
MPC 112
IGH 110
NHL 110
membrane-bound 109
IL-4 103
p38 102
annexin V 102
caspase-9 102
hinge 99
CD10 97
IFN-gamma 97
CD44 97
HLA-DR 96
CHOP 95
STAT 94
JAK2 94
IL-10 94
c-Myc 94
ICAM-1 94
NSD2 93
ERK1 93
RANK 92
HAT 91
CD28 90
IgA1 89
cereblon 89
p65 87
MEK 87
Pol 86
chronic renal failure 86
bcl-2 85
p27 85
CCND1 85
lectin 85
interleukin-2 84
KMS 84
JNK 84
Burkitt lymphoma 84
hepatocyte growth factor 84
CXCL12 84
interferon-alpha 83
surface antigen 83
ARH-77 83
IRF4 82
parathyroid hormone 81
CML 81
catenin 81
thrombin 81
cytochrome c 80
TRAIL 80
survivin 79
TNF-alpha 79
Cytokine 78
more...
Disease
multiple myeloma 36148
cancer 8996
tumor 5740
lymphoma 4906
leukemia 2469
Hodgkin's disease 1275
plasmacytoma 1262
monoclonal gammopathy of undetermined significance 1101
amyloidosis 1072
chronic lymphocytic leukemia 997
hematologic malignancies 965
anemia 933
gammopathy 875
acute myeloid leukemia 836
non-Hodgkin's lymphoma 805
hypercalcemia 781
chronic lymphocytic leukemia 779
bone disease 758
Leukemia 736
breast cancer 694
macroglobulinemia 649
renal failure 645
tumor growth 601
myelodysplastic syndrome 578
chronic myeloid leukemia 563
thrombocytopenia 555
carcinoma 530
acute lymphoblastic leukemia 515
B-cell lymphoma 486
metastases 479
neutropenia 476
melanoma 469
renal disease 435
peripheral neuropathy 432
proteinuria 426
minimal residual disease 424
osteoporosis 412
graft-versus-host disease 386
prostate cancer 384
plasma cell leukemia 379
extramedullary plasmacytoma 365
dysplasia 361
lung cancer 341
acute leukemia 307
tumor progression 295
rheumatoid arthritis 288
mantle cell lymphoma 286
tumorigenesis 282
lymphoproliferative disorders 281
bone metastases 275
Epstein 270
neuropathy 260
AL amyloidosis 260
renal insufficiency 256
Spleen 248
renal impairment 239
HIV 229
SDS 214
polyneuropathy 212
diabetes 210
plasmacytosis 205
SCID 204
pneumonia 198
Burkitt's lymphoma 190
immunodeficiency 184
adenocarcinoma 181
systemic lupus erythematosus 178
residual disease 168
paraproteinemia 164
hepatocellular carcinoma 162
follicular lymphoma 161
sepsis 159
SCT 158
myelosuppression 154
acute renal failure 153
POEMS syndrome 150
renal cell carcinoma 148
sarcoma 147
hypertension 147
ovarian cancer 146
heart failure 141
ISS 133
nephrotic syndrome 133
B-cell lymphomas 131
AIDS 131
osteosarcoma 130
sepsis 130
glomerulonephritis 129
lymphadenopathy 128
lymphoblastic leukemia 128
myeloproliferative disorders 128
solid tumor 126
Kaposi's sarcoma 125
neuroblastoma 124
infectious diseases 123
colon cancer 121
IgA myeloma 121
spinal cord compression 117
myelofibrosis 116
aplastic anemia 114
PDB 111
plaque 111
chronic renal failure 111
carcinogenesis 110
NHL 110
hairy cell leukemia 108
IgG myeloma 108
pancytopenia 108
cold 108
rash 107
cryoglobulinemia 106
pathological fracture 106
acute promyelocytic leukemia 103
leukopenia 102
vasculitis 101
colorectal cancer 100
gastric cancer 99
squamous cell carcinoma 97
cytomegalovirus 97
systemic disease 93
lung carcinoma 93
polycythemia vera 92
T-cell lymphoma 90
hyperviscosity syndrome 89
pancreatic cancer 88
rare disease 84
KMS 84
Infection 84
KMS 84
bladder cancer 82
Best 81
primary tumor 79
arthritis 79
congestive heart failure 77
B-cell chronic lymphocytic leukemia 76
Fanconi syndrome 76
obesity 76
lupus 76
hepatitis B 76
glioma 75
NAME 75
tuberculosis 73
virus infection 73
deep vein thrombosis 72
MCF 71
autoimmune disease 71
myeloid leukemia 71
Fanconi 70
IgD myeloma 70
influenza 70
non-small cell lung cancer 70
NOD 69
sarcoidosis 69
hepatitis 68
renal cancer 68
primary hyperparathyroidism 67
depression 66
glomerulosclerosis 66
glioblastoma 64
hypogammaglobulinemia 63
more...
Symptom
pain 602
bone pain 330
fatigue 314
diarrhea 172
nausea 154
weakness 145
dyspnea 144
back pain 126
constipation 105
vomiting 104
splenomegaly 96
anorexia 76
headache 74
collapse 69
hepatosplenomegaly 63
sleepiness 61
abdominal pain 59
hepatomegaly 55
low back pain 46
numbness 44
Ill 43
chest pain 41
cough 40
starvation 39
cachexia 36
paresthesia 34
nausea and vomiting 32
erythema 31
exhaustion 31
dizziness 28
discomfort 27
seizures 26
asthenia 25
discomfort 25
lethargy 25
respiratory distress 24
chills 22
overweight 21
fever of unknown origin 20
hoarseness 18
arthralgia 18
paresis 17
ataxia 17
syncope 16
shortness of breath 16
paraparesis 15
anesthesia 15
myalgia 15
blurred vision 15
polyuria 15
analgesia 14
oliguria 13
night sweats 12
angina 12
tremor 11
HSA 11
pallor 11
thinning 11
exertional dyspnea 11
polydipsia 10
decreased appetite 10
epigastric pain 10
shoulder pain 10
hip pain 10
consciousness disturbance 9
knee pain 9
neck pain 8
tingling 7
cancer pain 7
vertigo 6
arm pain 6
Welt 6
livedo 6
ophthalmoplegia 6
leg edema 6
agitation 6
acute abdomen 5
hypoproteinemia 5
Gastrointestinal symptoms 5
muscle cramps 5
dysarthria 5
flank pain 5
insomnia 5
hemoptysis 5
intestinal bleeding 4
dysuria 4
polymyalgia 4
neuralgia 4
facial pain 4
sore throat 4
acute abdominal pain 4
spasm 4
cyanosis 4
tense 3
hypercapnia 3
apathy 3
leg pain 3
thigh pain 3
muscle stiffness 3
Physical findings 3
rib pain 3
pedal edema 3
emaciation 3
rigors 3
dry skin 3
tonic-clonic seizure 3
abdominal discomfort 3
rales 3
ENT 3
abdominal fullness 3
stigma 3
hemiplegia 3
acute pain 3
jaw pain 3
nasal discharge 3
partial seizure 2
wheezing 2
distraction 2
Fluctuation 2
orthopnea 2
functional recovery 2
disturbed balance 2
abnormal gait 2
urinary frequency 2
photophobia 2
meningism 2
skin damage 2
Decreased activity 2
lassitude 2
clubbing 2
hypotonia 2
dry eye 2
chromosome marker 2
productive cough 2
Pain symptoms 2
limb pain 2
acidity 2
pelvic pain 2
catatonia 2
renal colic 2
neck stiffness 2
chronic back pain 2
Skin symptoms 2
breakthrough pain 2
excessive sweating 2
tachypnea 2
persistent cough 2
Neurologic symptoms 2
tinnitus 2
dental pain 2
Mechanical pain 1
syncopal episodes 1
hyperesthesia 1
sialectasis 1
non-productive cough 1
microbial colonization 1
monoplegia 1
Scratch 1
Sedation 1
dysesthesia 1
more...
Drug
Bortezomib 812
Lenalidomide 344
G-CSF 258
CSF 244
Dermatol 212
IL-2 163
lysine 136
CTX 103
IFN-gamma 96
Zoledronic acid 83
Zoledronic acid 69
Adriamycin 64
MDS 58
CAM 50
Arsenic trioxide 49
CTX 47
CTX 47
Revlimid 46
Rituximab 40
Dial 37
Cardiovasc 36
IL-11 33
MRC 31
ROS 29
PTH 26
Clodronate 25
ABC 24
Prednisone 24
Filgrastim 24
NVP 23
DEX 23
Gel 23
Denosumab 23
ADM 21
Filgrastim 20
Asn 20
Imatinib 20
TRM 19
VCR 18
ascorbate 18
Nephron 18
Nephron 18
MAP 17
APD 16
ROC 15
Albumin 15
Fludarabine 15
IFN-beta 15
Leaf 15
Monit 14
vitamin E 13
p75 13
CCL 13
Prednisolone 13
Hypaque 12
G418 12
Gleevec 12
Hypaque 12
lactose 12
VCR 12
Histamine 12
Campath 11
Vorinostat 11
Aredia 11
Campath 11
DNase I 11
Spectrum 10
Lovastatin 10
Intron A 9
Ibandronate 9
Intron A 9
Norplant 9
Intron A 9
Meth 9
Genasense 9
TAK 9
Activin 8
Idarubicin 8
Paraffin 8
Spectrum 8
ENT 8
-deoxyadenosine 8
Tipifarnib 8
ETS 7
Fragment 7
Vinorelbine 7
Dasatinib 7
Everolimus 6
Asthma 6
Herceptin 6
Serum albumin 6
TEL 6
NAG 6
Tocilizumab 6
Indomethacin 6
IL-1ra 6
Flavopiridol 6
Heme 6
Fraction 6
Amifostine 5
ampicillin 5
Epoetin alfa 5
uPA 5
Bonefos 5
Gallium nitrate 5
PTC 5
ALA 5
nitroglycerin 5
Etoposide 5
CTC 5
Mutagen 5
Forskolin 5
Pronase 5
Cetuximab 5
Taxol 5
GEO 5
Orphan 5
DMSA 4
Pravastatin 4
Galactose 4
ADR 4
Adenosine deaminase 4
Alanine 4
DDAVP 4
Mevastatin 4
Epoetin 4
EHDP 4
Sorafenib 4
Lenograstim 4
DM1 4
Portal 4
DDAVP 4
Glutathione 4
Papain 4
AraC 4
LMWH 4
Gefitinib 4
EE2 4
Thalomid 4
PFA 4
CTC 4
Erlotinib 3
Epigallocatechin 3
Novantrone 3
AZT 3
Romidepsin 3
L-tyrosine 3
Vindesine 3
Estrogens 3
PFT 3
RAL 3
Alliance 3
NADH 3
Vindesine 3
Tanespimycin 3
KGF 3
Amiloride 3
BH4 3
AZT 3
TAT 3
more...
Enzyme
proteasome 1373
ERK 495
mitogen-activated protein kinase 439
focal adhesion kinase 262
caspase-3 244
lactate dehydrogenase 199
peroxidase 194
alkaline phosphatase 177
protein kinase 176
trypsin 150
PARP 133
P-glycoprotein 122
MEK 116
CD10 108
caspase-8 103
reverse transcriptase 102
luciferase 100
caspase-9 87
thrombin 79
RNA polymerase 67
BMT 58
protein kinase C 57
neuraminidase 54
papain 54
RNase 50
RNase 50
phosphatidylinositol 3-kinase 49
acid phosphatase 46
APC 45
thymidine kinase 44
lysozyme 44
pepsin 43
topoisomerase 40
topoisomerase 39
IKK 38
DNA polymerase 37
ATPase 37
cdc2 35
MIP 35
collagenase 34
catalase 34
alanine aminotransferase 33
thromboplastin 33
endonuclease 32
glutathione S-transferase 31
MDR 30
urokinase-type plasminogen activator 29
DNA methyltransferase 28
ornithine decarboxylase 27
CD13 27
tissue plasminogen activator 26
ACS 25
ricin 24
phosphoinositide 3-kinase 24
superoxide dismutase 23
transcriptase 23
chymotrypsin 22
plasmin 22
aspartate aminotransferase 21
MDP 21
CDR 21
AMP-activated protein kinase 21
granzyme B 20
ribonuclease 20
beta-galactosidase 20
ribonuclease 20
farnesyltransferase 19
farnesyltransferase 19
CEP 17
calcineurin 17
aldehyde dehydrogenase 17
CEP 17
kinesin 16
cathepsin K 16
furin 15
MAP 15
asparaginase 15
phosphodiesterase 15
DNase 15
adenosine deaminase 15
glutamine synthetase 15
dihydrofolate reductase 14
sialyltransferase 14
sialyltransferase 14
CYP3A4 14
sialyltransferase 14
glucocerebrosidase 14
adenosine deaminase 13
renin 13
TSA 13
sialidase 13
IgA1 protease 13
S1 nuclease 12
glutathione peroxidase 12
TdT 12
PNGase F 12
aldehyde dehydrogenase 12
aldehyde dehydrogenase 12
aldehyde dehydrogenase 12
aldehyde dehydrogenase 12
creatine kinase 11
GSK 11
chloramphenicol acetyltransferase 11
tryptase 11
gamma-glutamyl transpeptidase 11
ceruloplasmin 11
AMPK 11
phospholipase A2 11
p100 11
AMPK 10
phospholipase C 10
micrococcal nuclease 10
adenylate cyclase 10
MMP 10
caspase-1 10
proteinase K 10
ubiquitin-protein ligase 9
lipase 9
beta-glucuronidase 9
methylenetetrahydrofolate reductase 8
prostate-specific antigen 8
thioredoxin reductase 8
hyaluronidase 8
ribonucleotide reductase 8
ribonucleotide reductase 8
BAL 8
acetylcholinesterase 8
methylenetetrahydrofolate reductase 8
CPT 7
CPT 7
hypoxanthine-guanine phosphoribosyltransferase 7
elastase 7
thyroid peroxidase 7
hyaluronidase 7
caspase-10 7
CPT 7
caspase-7 6
chitinase 6
MTD 6
DNA ligase 6
ACE 6
carboxylesterase 6
histone demethylase 6
subtilisin 6
beta-lactamase 6
arginase 6
DNA ligase 6
cathepsin B 6
transglutaminase 6
thermolysin 6
caspase-10 6
lipoprotein lipase 6
caspase-7 6
histone acetyltransferase 6
enolase 6
IgA protease 6
deaminase 6
demethylase 6
alpha-glucosidase 6
succinate dehydrogenase 5
more...
Compound
Clin 4830
Dec 2644
DNA 1828
calcium 602
creatinine 517
Neo 394
sodium 306
sulfate 289
oxygen 238
SDS 229
tyrosine 216
L-PAM 184
L-PAM 182
phosphate 178
PEG 173
His 169
lysine 163
glucose 162
MTT 140
water 139
methionine 139
TNF 138
galactose 135
ATP 131
nitrogen 131
acetate 124
leucine 124
urea 118
iron 114
iodine 113
cysteine 109
MPC 109
Congo red 107
CTX 103
arginine 100
retinoic acid 100
serine 100
bromide 91
Dexamethasone 88
MEK 86
BCNU 83
ammonium 79
alanine 74
threonine 74
Adriamycin 73
PEG 70
TBI 69
boron 69
NH2 67
Phe 62
vitamin D 61
glutamine 56
BCR 55
salt 53
ADP 53
CAM 52
Asp 52
Optimal 49
ABL 48
hydrogen 48
DEAE 45
potassium 45
ethanol 44
DNP 44
benzene 43
Histone 42
GSH 41
GSH 41
ADP 41
ADP 41
GlcNAc 40
MDA 39
isonicotinic acid 37
Dial 37
DBA 36
zinc 36
DBA 36
DBA 36
GalNAc 35
tryptophan 35
phosphorus 34
fluorine 34
methanol 34
Pac 34
Pamidronate 34
Insulin 34
SET 33
GTP 33
cAMP 33
copper 33
TOF 32
formaldehyde 32
nitric oxide 31
ammonia 31
MDR 31
pyrimidine 30
Vincristine 30
pyrimidine 30
Curcumin 30
tryptophan 30
tryptophan 29
tryptophan 29
VP-16 29
Gly 28
proline 28
GM1 28
acrylamide 28
glutamic acid 28
acetic acid 28
ADP-ribose 28
asparagine 28
NAD 28
uridine 27
HDM 27
PMA 26
A 71 26
Triton X-100 26
DMSO 26
MPT 26
ACS 26
GM3 26
EDTA 25
N-acetylcysteine 25
EDTA 25
Ile 25
ACS 25
Prednisone 24
Cardiol 24
COS 24
THP 24
ADR 24
2-mercaptoethanol 23
valine 23
CO2 23
NOXA 22
TSH 22
silver 22
NAD 22
acetone 21
neopterin 21
Hemoglobin 21
phenol 21
formaldehyde 21
THP 21
Thyroid 20
ASA 20
glutamate 19
Guo 19
PAS 19
Ara-C 18
MCNU 18
VLA 18
aspartic acid 18
aspartic acid 18
aspartic acid 18
aspartic acid 18
MAP 17
hexose 17
GM2 17
PMA 17
more...