Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026764 (multiple myeloma)
 36,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Male Balb C mice were immunized with a pure 32 kDa fragment of the porcine estradiol receptor spanning the domain E. Five antibody-producing hybridoma lines were established from fusions of spleen cells with the myeloma lines SPO and NSO. The antibodies were analyzed for interaction with native and with denatured intact receptor and receptor fragments, respectively. The antigenic determinant for antibody 13H2 is a native epitope which retains its combining activity after receptor denaturation. The antibodies 1F5, 1G5, 3E6 and 2H10 react with denatured proteins only. The presence of the determinants of all five antibodies has also been demonstrated in human, bovine, rat and mouse estradiol receptor.
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PMID:Characterization of five monoclonal antibodies raised against domain E of the porcine estradiol receptor. 769 29

Monoclonal antibodies (McAbs) were generated by fusion of SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with Giardia lamblia trophozoites. To define the effect of the McAb on Giardia lamblia, trophozoites were subcultured axenically after contact with McAb for 1 h at 37 degrees C. The McAbs 1G5 and 1E2 (both IgG1) were able to inhibit the growth of trophozoite at the rate of 63.4% and 35%, respectively. The inhibitory effect was decreased along with the decreasing quantity of McAb (from dilution 1:45 to 1:225) added to the TYI-S-33 medium. The actions of McAbs could be eliminated by absorption with trophozoites and not be influenced by complement in fresh guinea-pig serum, thus the actions of McAbs appeared to be specific and complement independent.
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PMID:[Study on the effect of monoclonal antibodies on Giardia lamblia in vitro]. 804 9