Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026764 (
multiple myeloma
)
36,148
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
It has been suggested that
VH4-34
gene segment expression is counter-selected in
multiple myeloma
(MM) due to a self-tolerance mechanism. We cloned and sequenced a
VH4-34
gene segment from bone marrow mononuclear cells of a stage III MM patient. We show that
VH4-34
was expressed by the serum IgA myeloma (M)-protein, as demonstrated by reactivity with the
VH4-34
specific 9G4 mAb and mass spectrometry (MS). The M-protein had weak reactivity with nuclei. These results demonstrate that
VH4-34
may be expressed in secreted IgA M-protein with weak autoreactivity. Thus, counter-selection of
VH4-34
is pronounced but not absolute in MM. Mechanisms of how
VH4-34
can occasionally be expressed in MM and clinical implications are discussed.
...
PMID:A VH4-34+ myeloma protein with weak autoreactivity. 1748 96
