Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026764 (
multiple myeloma
)
36,148
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Transient receptor potential melastatin 8 (TRPM8) is a member of the transient receptor potential superfamily of Ca
2+
channels. The aim of the present study was to clarify TRPM8 expression in reactive lymphoid tissues and mature B-cell neoplasms. Reactive and neoplastic lymphoid tissues were used to evaluate TRPM8 expression by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). TRPM8
+
cells were frequently detected in the follicular light zone and marginal zone of reactive lymphoid tissues. Double immunostaining revealed that TRPM8
+
cells co-expressed cluster of differentiation (CD) 38, CD79a, CD138, interferon regulatory factor 4/
melanoma associated antigen (mutated) 1
, B cell CLL/lymphoma 6 and transmembrane activator and CAML interactor. TRPM8
+
neoplastic cells were frequently detected in
plasma cell myeloma
. The positive band of TRPM8 mRNA was confirmed by RT-PCR in cases of
myeloma
. The present study is, to the best of our knowledge, the first to demonstrate the expression of TRPM8 in reactive lymphoid tissues and mature B-cell neoplasms, revealing that TRPM8 is frequently expressed in pre-plasmablasts, plasmablasts, plasma cells and mature B-cell lymphomas that are likely to differentiate into plasma cells.
...
PMID:Expression of TRPM8 in human reactive lymphoid tissues and mature B-cell neoplasms. 3034 43
