Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026764 (multiple myeloma)
 36,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The third case of myeloma presenting as a lacrimal gland tumor is reported. The lesion was originally diagnosed as a solitary extramedullary myeloma, but on follow-up, the patient was seen to develop other myelomas. This case illustrates the necessity for careful follow-up of patients with solitary myelomas, even in the absence of bone marrow pathology, for the solitary extramedullary myeloma may represent an early stage in the development of multiple myeloma.
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PMID:Multiple myeloma involving the lacrimal gland. 118 Apr 64

Monoclonal antibodies (mAb) were generated as probes for the plasma membrane domains of pancreatic acinar cells. Primary monolayer cultures of mouse pancreatic acinar cells, which have an expanded apical surface relative to normal pancreas, were used to immunize rats. With conventional immunization and fusion protocols, 3% of the hybridomas were positive against the acinar lumen by indirect immunofluorescence of mouse pancreas cryosections. Culturing of spleen cells from an immunized rat on the apical surface of acinar cell monolayer cultures before fusion with the myeloma (an in vitro boost) doubled the percentage of hybridomas producing apical membrane-specific mAb. Monoclonal antibodies were characterized by immunofluorescence, ultrastructural immunoperoxidase cytochemistry, immunoprecipitation, and immunoblotting. One antibody, acinar-1 (IgG2a), labeled the apical membranes of pancreatic acinar cells, hepatocytes, salivary and lacrimal gland acinar cells, and the brush border of small intestine enterocytes. This mAb precipitated and blotted a protein of 94 KD. Acinar-2 (IgM) also labeled pancreatic acinar cell apical membranes but did not label other tissues and did not precipitate or blot. Acinar-3 labeled pancreatic acinar cell lateral membranes. Duct-1 (IgM) labeled pancreatic duct apical membrane and ducts in liver and salivary glands but did not precipitate or blot. These domain-specific mAb demonstrate that common antigenic determinants occur in the apical surfaces of several exocrine epithelia and may be important in secretion.
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PMID:Monoclonal antibodies as probes for plasma membrane domains in the exocrine pancreas. 329 43

The pathway taken by membrane that is recovered by endocytosis from the surface of secretory cells was investigated with electron-dense tracers 9dextrans and cationized ferritin). The cell types examined included exocrine cells of the parotid and lacrimal glands, endocrine cells of the anterior pituitary gland, and immunoglobulin-secreting cells from lymph nodes or myeloma cell lines. In all cases, when the cells were incubated at 37 degrees C the tracers were initially taken up by endocytosis and they later appeared in the stacked Golgi cisternae, in immature secretion granules or vacuoles and in lysosomes. Similar results were obtained after covalent labelling of surface membrane constituents when myeloma cells were radioiodinated and the fate of the labelled components was followed by autoradiography. Initially only the cell surface was labelled, and the autoradiographic grains were concentrated over the plasmalemma. After incubation at 37 degrees C some of the labelled components were internalized (by endocytosis), and the majority of the internal autoradiographic grains were found over Golgi cisternae and over associated secretory vacuoles, which were the only organelles significantly labelled. The findings indicate the existence of considerable membrane traffic from the plasmalemma to the stacked Golgi cisternae and forming secretion granules or vacuoles in all these cell types. Membrane is thus continually recovered from the cell surface of secretory cells and funnelled through the Golgi complex; moreover, the plasmalemma-to-Golgi traffic appears to represent a major route of membrane traffic in secretory cells. A large portion of this traffic appears to be associated with the recycling of the membrane containers used in the packaging of secretory products.
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PMID:Membrane recycling in secretory cells: pathway to the Golgi complex. 618 82

Microsomes prepared from several animal sources were analyzed for the presence of proteins corresponding to the ribophorins (I and II) which have been previously characterized in rat liver rough microsomes and appear to be involved in the binding of polysomes to endoplasmic reticulum membranes. In rough microsomal membranes from rat lacrimal gland, rabbit liver, dog and chicken pancreas, and mouse myeloma, ribophorin-like polypeptides with similar electrophoretic mobilities were detected by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. In all cases the polypeptides remained associated with sedimentable polysomes after solubilization of the microsomal membranes with nonionic detergents. Ribophorin-like polypeptides were absent from smooth microsomes. Antibodies raised against each rat liver ribophorin, purified by preparative sodium dodecyl sulfate/polyacrylamide gel electrophoresis, immunoprecipitated only the corresponding polypeptide, indicating no crossreactivity between ribophorins I and II. These antibodies also immunoprecipitated the homologous ribophorins found in microsomal preparations from other organs and species.
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PMID:Identification of ribophorins in rough microsomal membranes from different organs of several species. 708 28

The authors present a rare case of plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma in a 42-year-old woman. The lesion was surgically removed and analyzed. Histopathological examination with immunostaining revealed it to be positive for immunoglobulin G and Kappa chains, demonstrating monoclonality. However, no abnormality was observed on serum electrophoresis, skeletal survey and bone marrow aspiration. Therefore, the tumor was diagnosed solitary plasmacytoma of bone. The patient was treated with external beam radiotherapy and has remained disease free for 5 years and 6 months until 2007, when she presented a pathological fracture due to multiple myeloma. Extensive medical work-up to rule out multiple myeloma or other malignant lymphoproliferative conditions involving orbit or ocular adnexa is needed when the diagnosis of solitary plasmacytoma of bone is suspected because treatment and prognosis are very different.
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PMID:Plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma: case report. 1946 36

A 64-year-old white man presented with a plasma cell neoplasm in the right lacrimal sac. After successful surgical excision and radiation treatment, he developed a local adjacent recurrence, which again responded to radiation. He subsequently developed a distant plasma cell neoplasm in the humerus, but he continues to have no sign of multiple myeloma on systemic evaluation during 2 years of follow-up. This unusual case is compared with other reported cases of plasma cell neoplasm in the published literature.
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PMID:Ophthalmic presentation of plasma cell neoplasm. 1961 95

An 80-year-old man presented with an 8-week history of painless swelling in the right lacrimal gland region with infero-medial dystopia of the globe. The lesion was excised and histology confirmed an orbital plasmacytoma. Multiple myeloma screening was negative and a solitary extramedullary plasmacytoma arising from the lacrimal gland was diagnosed. The patient was subsequently treated with radiotherapy.
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PMID:Extramedullary plasmacytoma arising from the lacrimal gland. 2065 91

Autologous stem cell transplantation (ASCT) can prolong remission duration, overall and progression free-survival in multiple myeloma (MM). Ocular relapse is rare in MM. Here we present a patient with only ocular relaps and without evidence of bone marrow progression after ASCT. Ig A kappa myeloma, stage IIIA was diagnosed in a 53-year-old man, according to Kyle-Greipp and Durie Salmon. He was treated with three courses of VAD therapy. Then he received high dose melphalan (200 mg/m2), followed by the ASCT. After two months from ASCT, he had bilateral blurry vision, pain, redness in both eyes and diplopia. We detected 5 mm of right-sided proptosis by Hertel exophthalmometry (base 110, 20 mm right eye, 15 mm left eye). Ocular motility of oculus dexter (OD) was restricted in up and lateral gaze. He has diplopia in up gaze. His color vision was 7 of 12 in the right eye and 10 of 12 in the left eye with Ishihara plates. Best corrected visual acuity was 6/10 in the right eye and 7/10 in the left eye. Intraocular pressures were 19 mmHg for OD and 18 mmHg for oculus sinister (OS). Slit lamp biomicroscopy revealed subconjunctival hemorrhages superiorly and temporally in the right eye and bilateral conjunctival hyperemia with chemosis. Fundus examinations of both eyes were unremarkable. Computed tomography and magnetic resonance imaging of orbita revealed a right intraorbital extraconal soft tissue density mass that involved the lacrimal gland and lateral rectus muscle. Prednisolon 1mg/kg/day and bortezomib 1.3 mg/m2 were started (1, 4, 8, 11 days). Eye findings were recovered after one month. Ocular relapse should be considered if there are ocular findings after ASCT for MM. Bortezomib and steroid may be useful for ocular extramedullary relapse of MM (Fig. 2, Ref. 8).
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PMID:Successful treatment of early relapse of ocular myeloma with bortezomib and steroid after autologous stem cell transplantation. 2138 38

Plasmacytomas are plasma cell neoplasms that rarely involve ocular adnexal tissues as a primary lesion or secondary manifestation of plasma cell myeloma. Only one case of plasmacytoma involving the lacrimal drainage system, to our knowledge, is described in the literature. The clinical presentation of ocular adnexal primary plasmacytoma typically relates to its mass effect. In this clinicopathologic report, we describe an unusual presentation of primary plasmacytoma of the lacrimal canaliculus as infectious canaliculitis.
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PMID:Plasmacytoma associated with canaliculitis. 2174 65

Ocular adnexal lymphoma (OAL) is a rare manifestation of non-Hodgkin lymphoma consisting of the tissues and structures surrounding the eye that include the conjunctiva, eyelids, lacrimal gland, and orbital soft tissues. OAL comprise 1% to 2% of all non-Hodgkin lymphomas and about 8% of the extranodal lymphomas; however, the incidence of OAL has increased by approximately 6% annually in last 2 decades, and OAL now represents the majority of orbital malignancies. There are no uniform treatment guidelines for OAL. Because of high local and extraorbital recurrence rates, appropriate local, systemic, or combined treatment must be applied.
Clin Lymphoma Myeloma Leuk 2015 Jun
PMID:Ocular Adnexal Lymphomas: Single-Center Experience. 2629 70


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