Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026764 (
multiple myeloma
)
36,148
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Cell adhesion mediated drug resistance (CAM-DR) is a major factor that impedes the effect of chemotherapy in
multiple myeloma
(MM).
RBQ3
, which is a RB-binding protein, played a crucial role in cell cycle process. Here, we reported that
RBQ3
expression was increased gradually during the proliferation process of
myeloma
cells. Knocking down of
RBQ3
resulted in cell cycle arrest in G1 phase and increased
myeloma
cells adherent to fibronectin or bone marrow stromal cells (BMSCs). Furthermore, silencing of
RBQ3
reduced sensitivity to chemotherapeutic drugs in
myeloma
cell lines adherent to BMSCs and reduced two apoptotic marker proteins cleaved caspase-3 and cleaved PARP expression. Besides, we also found that
RBQ3
participated in MAPK/ERK signal transduction pathway. In summary, these results may shed new insights into the role of
RBQ3
in the development of
multiple myeloma
.
...
PMID:RBQ3 participates in multiple myeloma cell proliferation, adhesion and chemoresistance. 2718 1
