Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026764 (
multiple myeloma
)
36,148
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Lycorine
, a natural alkaloid, has been widely reported to possess potential efficacy against cancer. However, the anti-
multiple myeloma
mechanism of lycorine is not fully understood. In this study, the results demonstrated that lycorine is effective against
multiple myeloma
cell line ARH-77 via inducing programmed necrosis. The mechanisms of lycorine on the
multiple myeloma
cell line ARH-77 are associated with G1 phase cell cycle arrest, mitochondrial dysfunction, reactive oxygen species (ROS) generation, ATP depletion, and DNA damage. Our results elucidate the new mechanism of lycorine against
multiple myeloma
.
...
PMID:Lycorine induces programmed necrosis in the multiple myeloma cell line ARH-77. 2548 18
Despite the use of novel anti-
myeloma
agents,nearly all patients will eventually relapse or become refractory to drug treatment. New and more effective drugs for
multiple myeloma
(MM) are urgently needed. The JAK-STAT signaling pathway is important in the proliferation of
myeloma
cells.
Lycorine
,a natural alkaloid extracted from amaryllidaceae, has shown anti-tumor effects against a variety of solid tumors. However, its effects on MM remain unclear.In this study,we found that lycorine inhibited cellular viability and induced cell death in MM cell lines and primary
myeloma
cells which were derived from our four MM patients. The study showed that
myeloma
cells' cycle was being arrested under the G0/G1 phase followed by the lycorine treatment. Further mechanism analysis demonstrated that lycorine inhibited JAK2/STAT signaling through upregulation of SOCS1 in MM cells and patient MM cells.Importantly, we found that knockdown of HDAC8 resulted in increased expression of SOCS1. Collectively, our findings suggested lycorine acted as a potent novel histone deacetylase inhibitor and inhibited JAK2/STAT signaling through upregulation of SOCS1 in MM cells.
...
PMID:Lycorine induces cell death in MM by suppressing Janus Kinase/signal transducer and activator of transcription via inducing the expression of SOCS1. 2784 3
