Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026764 (multiple myeloma)
 36,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Recent results of studies employing tolerogenic monomethoxypolyethylene glycol (mPEG) conjugates of antigens are briefly reviewed. Administration of antigen (mPEG)n conjugates into mice induced antigen-specific suppressor T (Ts) cells, from which a suppressor factor (TsF) was extracted. These Ts cells were cloned and shown to be Thy1.2+, CD3+, CD4-, CD5-, CD8+ and to express the alpha beta heterodimer of conventional T cell receptors (TCR). The TsF of a clone of OVA-specific Ts cells shared the epitopes of the alpha and beta chains of TCR, whereas the TsF of T cells of an HIgG-specific clone shared only the epitope of the alpha chains of TCR; OVA and HIgG represent ovalbumin and human monoclonal (myeloma) IgG. These studies have provided evidence for the phenomenon of "linked immunological suppression" which may be summarized by the statement "Ts cells specific for an epitope of a given antigen, AgA, suppress the antibody response to an unrelated antigen, AgB, only if the latter is presented in the form of a covalent adduct, AgA-AgB, to the immune system of the animal pretolerized with AgA (mPEG)n, but not if AgB is presented as a mixture with AgA.
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PMID:Suppressor T cells induced in vivo by tolerogenic conjugates of a given antigen and monomethoxypolyethylene glycol downregulate antibody formation also to a second antigen, if the latter is presented as a covalent adduct with the former. 183 92

Studies were undertaken to determine a possible structural relationship between the secretory component (SC) and the receptor for IgA (Fc alpha R). An IgA-mediated rosetting technique was used to assess the presence of Fc alpha R+ cells in various lymphoid tissues from normal BALB/c mice and mice bearing an IgA plasmacytoma (MOPC 315). Tissues from the MOPC 315-bearing BALB/c mice were found to have a significantly higher percentage of Fc alpha R+ cells; thus, nonadherent spleen cells from MOPC 315-bearing mice were used as a source of Fc alpha R+ cells in these studies. The cells were preincubated with anti-SC and then assayed for the ability of IgA to bind to the Fc alpha R. Antisera to SC from various species inhibited the formation of IgA-mediated rosettes, although preincubation of the Fc alpha R+ cells with antisera directed against other cell surface molecules (e.g., Thy1.2, Lyt1, Lyt2, Fc gamma R, MHC class I and II) or preimmune sera had no significant effect on IgA-mediated rosette formation. Preabsorption of the anti-SC with secretory IgA or with free SC removed the inhibitory effect; preabsorption with myeloma IgA had no effect. These data suggest that SC and Fc alpha R are related serologically and may be structurally related, possible in the IgA-binding region.
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PMID:Antisera to the secretory component recognize the murine Fc receptor for IgA. 278 69