Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026764 (
multiple myeloma
)
36,148
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Cerebral infarction is an uncommon complication in
multiple myeloma
with hyperviscosity. Serum hyperviscosity may cause a variety of clinical manifestations including bleeding from mucosal membranes, congestive heart failure, retinopathy, and various neurologic deficits. These manifestations have been attributed to the presence of large quantities of asymmetrical molecules of high molecular weight in the serum. We recently experienced a case of
multiple myeloma
with acute cerebral infarction, which caused by hyperviscosity, as an initial manifestation in IgG
multiple myeloma
, and reviewed the relevant literature of
myeloma
presenting with the stroke. A 68-yr-old woman abruptly developed hypesthesia and
monoplegia
in the left leg. The stroke confirmed by the brain MRI and MR angiography, which revealed acute infarction at the right anterior cerebral artery territory. On admission, routine blood tests showed a slight decrease in hemoglobin and a marked increase in erythrocyte sedimentation rate. Peripheral blood smear, serum protein electrophoresis, serum visocity, and bone marrow aspiration showed that she had IgG
multiple myeloma
with hyperviscosity. She was treated by chemotherapy with cyclophosphamide and discharged with the improved clinical condition.
...
PMID:Cerebral infarction in IgG multiple myeloma with hyperviscosity. 1610 Apr 71
