Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026764 (
multiple myeloma
)
36,148
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We present an unusual case of nasopharyngeal amyloidosis associated with
multiple myeloma
. A 63-year-old woman presented with 2 months' history of epistaxis and
dentalgia
3 years after being diagnosed with
multiple myeloma
. CT and C-Pittsburgh compound B (PiB) PET images demonstrated that the intense C-PiB uptake corresponded to the nasal, paranasal, and palatal area matching the CT mass lesion. Histopathologic examination confirmed amyloidosis.
...
PMID:11C-PiB PET/CT in nasopharyngeal amyloidosis associated with multiple myeloma. 2514 May 65
Patients with
plasma cell myeloma
may initially present to their dentists or dental surgeons with
toothache
, loose teeth, or gingival masses. An X-ray of the jaw can reveal osteolyses. In addition, accumulation of monoclonal light chains in AL-amyloidosis can lead to macroglossia. It is prudent that the dentist or dental surgeon recognizes the underlying disease and refers the patient to the oncologist or hematologist for further workup to prevent the complications of
plasma cell myeloma
such as renal impairment, fractures, bone pain, infections, hypercalcemia, anemia, or heart failure. Another area where the dentist or dental surgeon is involved with patients suffering from
plasma cell myeloma
is prevention and therapy of osteonecrosis of the jaw, occurring after administration of bisphosphonates or denosumab for osteolytic bone disease. The case report presented here shows a patient complaining of
toothache
for whom recognition of a systemic disease by the dentist led to the diagnosis of
plasma cell myeloma
, highlighting the need for interdisciplinary cooperation. As recent years have seen many changes in the management of patients with
plasma cell myeloma
, an update for dentists and dental surgeons is warranted.
...
PMID:Toothache as the initial symptom of plasma cell myeloma. 3014 14
