Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026764 (multiple myeloma)
 36,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the decade 1973-1982, data from all the principal diagnostic centers in Italy reveals that swine lymphoid and myeloid neoplasms (LMN) have been observed only few times (78 cases). In a 25-year period (1950-1984) 48 cases were diagnosed in our Institute, among which all the known forms of LMN, including the most uncommon such as multiple myeloma (1) and myeloid forms (4) including 1 chloroma and 1 erythraemic neoplasm. The incidence remains low; 1.17% of the diseased swine sent for necropsy, with no significant increase during the years. In the same period the incidence of other neoplasms was 1.14%. Also the data from the abattoir of Bologna confirm a low incidence: in the last 2 years lymphoid neoplasms were observed only twice among 130,000 slaughtered pigs (15 cases per million). This incidence is therefore similar to that noticed in slaughterhouses in other European countries and in the U.S.A. As for the anatomohistopathological features, lymphosarcoma presents a constant autochthonous production of immature collagen fibrils, but the degree of this production has no significant relation with either the macroscopic type of lesions, nodular or infiltrating (diffuse), or the level of cellular differentiation. Diffusely haemorrhagic lesions were observed in a relatively high percentage (14%) of lymphosarcomas. The incidence of myeloid neoplasms is relatively high compared with that of lymphosarcomas: from 5% of Italian cases as a whole to 14% of the cases studied in our Institute. This confirms that the pig is second to the dog as a domestic animal showing most of these myeloid neoplasms.
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PMID:Swine lymphoid and myeloid neoplasms in Italy. 331 13

The incidence of hematologic malignancies and their extranodal manifestations is continuously increasing. Previously unsuspected hepatic involvement in hematologic malignancies such as Hodgkin disease and non-Hodgkin lymphoma, posttransplant lymphoproliferative disorder, myeloid sarcoma (chloroma), multiple myeloma, Castleman disease, and lymphohistiocytosis may be seen by radiologists. Although the imaging features of more common hepatic diseases such as hepatocellular carcinoma, metastases, and infection may overlap with those of hepatic hematologic malignancies, combining the imaging features with clinical manifestations and laboratory findings can facilitate correct diagnosis. Clinical features that suggest a hematologic neoplasm as the cause of liver lesions include a young patient (<40 years of age), no known history of cancer, abnormal bone marrow biopsy results, fever of unknown origin, and night sweats. Imaging features that suggest hematologic malignancy include hepatosplenomegaly or splenic lesions, vascular encasement by a tumor without occlusion or thrombosis, an infiltrating mass at the hepatic hilum with no biliary obstruction, and widespread adenopathy above and below the diaphragm. Familiarity with the imaging features of hepatic hematologic malignancies permits correct provisional diagnosis and may influence therapeutic management. For example, when biopsy is performed, core biopsy may be needed in addition to fine-needle aspiration so that the tissue architecture of the neoplasm can be discerned. The predominant treatment of hematologic malignancies is chemotherapy or radiation therapy rather than surgery. Online supplemental material is available for this article.
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PMID:Hematologic malignancies of the liver: spectrum of disease. 2656 43