Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026764 (
multiple myeloma
)
36,148
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Multiple myeloma
is one of incurable hematological malignancies and targeted therapies for novel oncogenes are to be exploited. Analyses of
multiple myeloma
patients revealed that HOXA9 was overexpressed in patients lacking known IgH translocation and it was evaluated as a candidate oncogene in multiple myeloma. This overexpression of HOXA9 was supposed to be due to dysfunction of histone methyltransferases (HMT) and mutations in MLL encoding HMT were found. Panobinostat, an HDAC inhibitor is currently undergoing preclinical and clinical evaluation as a novel drug for
multiple myeloma
. We found that panobinostat suppresses expression of
MLL protein
through modulation of its stability as well as Hsp90 inhibitor. More precise roles of MLL in pathogenesis of
multiple myeloma
are to be elucidated.
...
PMID:[Discovered roles of MLL in pathogenesis of multiple myeloma]. 2501 2
