Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026764 (multiple myeloma)
 36,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Gastric myeloma is a rare malignant tumor composed of atypical plasma cells and represents, as a rule, only the initial manifestation of widespread myelomatous proliferation. Roentgenographically, it may be indistinguishable from carcinoma of the stomach or it may present as a large intramural mass, often situated along the greater curvature of the stomach. The association of a malignant looking gastric lesion with clinical or radiographic evidence of multiple myeloma should strongly suggest the diagnosis.
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PMID:The radiology corner. Gastric myeloma. 113 Apr

A 65-year-old man was admitted because of bleeding from gastric ulcer. A massive deposition of AL lambda type amyloid proteins in the gastric lesion was found. There were a few Bence-Jones (BJ) proteins in the urine, but serum M proteins and bone lesions were not found. Bone marrow puncture showed no dysplastic change of plasma cells. Moreover, there were no amyloid proteins deposited anywhere in the digestive tract examined, except for the stomach, nor were they found in the bone marrow, prostata, liver or kidney. Gastric amyloidosis was diagnosed. Gastrectomy was performed because of uncontrollable bleeding. Sixteen months later, bone swelling occurred in the sternoclavicular joint and the 3rd rib. At that time, plasma cells with dysplasia and increasing levels of urine BJ protein were revealed. BJ type multiple myeloma was finally diagnosed. For remission induction, cyclo-VAMP chemotherapy was given in 3 courses. Decreased levels of urine BJ protein, diminished bone lesion, normalization of bone marrow and fewer amyloid deposits were seen, and partial response was obtained. The patient is well with no signs of recurrence evident 42 months after treatment. This is an interesting case of initial gastric amyloidosis that developed into BJ type multiple myeloma and was effectively treated with cyclo-VAMP chemotherapy.
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PMID:[A case of gastric amyloidosis developing into Bence-Jones type multiple myeloma, treated effectively by cyclo-VAMP chemotherapy]. 825 60

The authors here present a rare case of systemic amyloidosis with multiple myeloma. The patient was a 55-year-old man who presented with complaints of dysphagia and skin lesions. From clinical examination and endoscopic findings, gastric carcinoma was suspected and biopsy was taken from the gastric lesion. Histopathological examination of gastrointestinal biopsy revealed amyloid deposits. The patient also had multiple skin lesions, which also showed cutaneous amyloidosis. Owing to the presence of gastric amyloidosis, the patient was investigated further with serum electrophoresis and bone marrow biopsy, which revealed multiple myeloma.
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PMID:Amyloidosis masquerading as gastric carcinoma - A case report. 3203 Nov 39