Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026764 (multiple myeloma)
 36,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Amyloidoma primarily involving bone and lymph node is described in a 60-year-old male patient. The patient had pathologic fractures of both hips through a deposit of amyloid in the neck of the femur. The prolonged insidious course of the disease was uncomplicated by hypercalcemia, hematologic abnormalities, or renal failure so characteristic of untreated myeloma. The bone marrow contained less than 10 percent plasma cells in different stages of maturity. Radionuclide bone scanning demonstrated other osseous amyloid lesions that were not detected by routine radiologic examination. This is the first reported case of pathologic fractures of both hips secondary to amyloidoma.
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PMID:Pathologic hip fractures secondary to amyloidoma. Case report and review of the literature. 649 50

We report a case with protruding inguinal masses for 6 months, in whom muscular amyloidoma was not suspected before muscle biopsy. On pelvic magnetic resonance imaging (MRI), round masses showing peripheral rim enhancement with gadolinium were observed in iliopsoas and iliacus muscles of both inguinal areas. The same lesions were also observed in gluteus muscles. The biopsy showed Congo red positive materials in a dense fibrous background. Serum and urine electrophoresis showed Bence Jones protein, lambda type. In bone marrow section, myeloma cells were found. Peripheral blood stem cell transplantation (PBSCT) following four cycles of VAD (vincristine, adriamycin, dexamethasone) chemotherapy was performed and the result was satisfactory. Amyloidoma lesions decreased in size and number on the following MRI.
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PMID:Muscular amyloidoma presenting as inguinal masses in multiple myeloma. 1609 14

We report a case of a spontaneous hip fracture in a context of dysglobulinemia. The bone histologic examination found amyloidoma. Amyloidoma is an overload pathology and an unusual cause of fracture. In most of the cases, it is associated with myeloma and the difference between bone invasion of myeloma and amyloidoma in an osteolytic radiographic picture is not easy but is of importance because prognosis and treatment may be totally different. Thus, in the context of dysglobulinemia, one must keep in mind that spontaneous bone fracture may be due to amyloidoma with another prognosis.
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PMID:Amyloidoma, an unusual cause of fracture. 2474 47