Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026764 (multiple myeloma)
 36,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The structure of human ethmoid bone may be characterized not only by the labyrinthine complexity, but also by asymmetry, numerous variations and deformity. Another important specificity is the co-existence of evoluted and nonevoluted structures. These characteristics are probably the result of encephalization and insufficient adaptation due to rapid evolution since man descended to the ground from his arborial life. Kyphosis of the cranial base, displacement of the lamina lateralis anterosuperiorly and rotating of both orbits antero-medialy, restricted the space where the numerous ethmotubinates were to grow. In quadrupeds and in lower primates, the lamina lateralis serves as the site of attachment for turbinates, exists in the antero-inferior part of the nasal cavity forming a medial wall of the sinus maxillaris. However, in human and in higher class primates also this lamina enters the orbit as the lamina orbitalis or lamina papyracea participating in the medial wall of the orbita. The lamina cribrosa, the other site of attachment of turbinates, displaces to antero-superior upon the nasal cavity. Thus, the course of the basal lamellae of turbinates are forced to bend from an antero-superior to a postero-inferior direction. Then, in human, who have more turbinates (Denker u. Kahler, 1925; Miller, 1964; Negus, 1958) than simiae (Ehara, 1974; Ishii, 1955), numerous basal lamellae with scrolls, compress each other with overlapping, fusion, displacement or deformities. With further compression by a deviated septum and the space-filling effect in its concave side, the ethmoid becomes increasingly complex. The complexity of the human ethmoid bone warrants further anthropological and biostatical study with regard to the pneumatisation theory.
Auris Nasus Larynx 1982
PMID:Characteristics and origin of the human olfactory organ. 718 52

Extramedullary plasmacytoma (EMP) is a rare plasma cell neoplasm that occurs in the soft tissues, especially in the upper airways. We report two cases of laryngeal EMP, both of which were treated by surgical resection, one with and one without combination radiotherapy. A 39-year-old male was diagnosed with a laryngeal tumor localized in the left arytenoid region in October 1999. Biopsy showed the tumor to be a plasmacytoma. He underwent a direct laryngoscopy and resection of the tumor with a KTP laser. Consequently, he received radiotherapy to a total dose of 60 Gy. He has remained clear, with no local recurrence during 6 years of follow-up. A 59-year-old male was diagnosed with an epiglottic tumor in December 1989. He underwent a direct laryngoscopy and removal of the tumor. Histopathological study of the tumor showed a diffuse proliferation of plasmacytoid cells. He has remained diseasefree during 15 years of follow-up.
Auris Nasus Larynx 2006 Jun
PMID:Extramedullary plasmacytoma of the larynx. 1640 28

Multiple myeloma, solitary plasmacytoma, and extramedullary plasmacytoma constitute a continuous disease spectrum of plasma cell neoplasms. In the larynx, although extramedullary plasmacytoma in the supraglottic region has been sometimes reported, plasma cell neoplasm with involvement of the thyroid cartilage is extremely rare. We report a case of multiple myeloma involving the thyroid cartilage. A 72-year-old male patient presented with a pathological fracture of the cervical vertebrae. CT scan revealed low-density areas within the thyroid cartilage, but the laryngeal mucosa and submucosal soft tissue were intact. Multiple myeloma was diagnosed, since the tumors in the thyroid cartilage and cervical vertebrae revealed plasmacytoma. Because no other lesion was found, irradiation of the larynx and cervical vertebrae was performed. Neither aggressive change of these lesions nor new lesions have been found over 3-year follow-up following the initial treatment without adjuvant therapy.
Auris Nasus Larynx 2007 Jun
PMID:Multiple myeloma involving the thyroid cartilage. 1708 53

Neoplasms originating from plasma cell are rare in the head and neck region. A correct clinical evaluation is very important in order to formulate a differential diagnosis as well as to distinguish local from metastatic disease. We report a case of larynx involvement by an IgA multiple myeloma in a 69-year-old female diagnosed in October 2004 and treated with chemotherapy; the 1 year control do not show progression of disease and the laryngeal lesion is unchanged. We highlight the radiological findings and clinical features to suspect plasma cell tumors in cases with a similar presentation.
Auris Nasus Larynx 2008 Jun
PMID:Thyroid cartilage involvement in patient affected by IgA multiple myeloma: case report. 1782 11

Antiresorptive drugs have been widely used to treat patients with hypercalcemia caused by malignancy, bone metastasis, multiple myeloma, and osteoporosis. However, it is well known that antiresorptive drugs can cause osteonecrosis of the jaw (ONJ). Herein, we report a rare case of nasal septal abscess caused by medication related osteonecrosis of the jaw (MRONJ) in a breast cancer patient. A 69-year-old woman was referred to our clinic for evaluation of nasal obstruction. Physical examination revealed a cherry-like swelling of the nasal mucosa emanating from the septum that obstructed both nasal cavities and a fistulous tract showing pus discharge after extraction of the bilateral maxillary central incisors (MCI) and the right maxillary lateral incisor (MLI). Computed tomography and panoramic radiography revealed extensive osteonecrosis of the maxilla and swelling of the nasal mucosa. The clinical diagnosis was nasal septal abscess caused by osteonecrosis of the maxilla. Surgical procedure was undertaken for this case. An indwelling drain was placed in the oral cavity, and sequestrectomy was performed with incision and drainage of the anterior portion of left nasal septum. The patient was doing well at the 7-month follow-up. The patient had a medical history of breast cancer with bone, lung, liver metastases, and had received intravenous bisphosphonate, which is one of the antiresorptive medicines, over the past 4 years. We suspect that this history played an important role in MRONJ induced nasal septal abscess.
Auris Nasus Larynx 2016 Feb
PMID:A case of nasal septal abscess caused by medication related osteonecrosis in breast cancer patient. 2677 49