Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026764 (multiple myeloma)
 36,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Obstruction of renal collecting tubules by protein cats inciting a giant cell reaction is usually characteristic of myeloma cast nephropathy. Rarely other causes of proteinuria may result in a similar morphology. We report a rare case of 'myeloma-like' tubular casts in the kidney of a patient who was subsequently found at autopsy to have acinar cell carcinoma of the pancreas with peritoneal carcinomatosis. Only two similar reports could be found in the English literature.
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PMID:Myeloma-like cast nephropathy associated with acinar cell carcinoma of the pancreas. 323 1

Plasmacytomas can be divided into multiple, solitary osseous and solitary extraosseous/extramedullary plasmacytomas. Intracranial plasmacytomas of the dura, leptomeninx and cerebrum are well known from the literature. They are manifestations of multiple myeloma, intracranial extramedullary plasmacytoma or metastatic disease of extramedullary plasmacytoma in distant locations. We describe a cerebellar manifestation of a solitary plasmacytoma of the bone, and a leptomeningeal carcinomatosis of a multiple plasmacytoma. A summary of the literature concerning intracranial plasmacytomas is given. Dural manifestations of plasmacytoma have the same features as meningiomas in CT or MRI. Cerebral or cerebellar manifestations cannot be differentiated from brain tumors by means of CT or MRI. In CT, plasmacytomas show high-density lesions. T2w-MRI reveals a low-intensity lesion. In T1w-MRI, intense homogeneous contrast enhancement can be demonstrated.
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PMID:[Rare intracranial plasmacytoma manifestations. Case reports and review of the literature in diffuse plasmocytoma, in primary solitary extramedullary plasmacytoma in in primary solitary osseous plasmacytoma]. 903 33

Venous thromboembolism is a frequent complication in cancer patients. The pathogenesis of Trousseau's syndrome might be driven by the transcriptional response to the MET oncogene, including prominent upregulation of plasminogen activator inhibitor type 1 and cyclooxygenase-2 genes. Vascular intimal carcinomatosis refers to a characteristic tumor proliferation on vascular intima that replaces the normal endothelium. Annexin2-mediated fibrinolysis on carcinoma cells may play a role in inducing hemorrhagic disorder in vascular intimal carcinomatosis. It would be an advantage to have knowledge of predictive parameters for the development of thrombosis and to be able to select cancer patients individually according to their risk profile. Thromboprophylaxis in hospitalized and cancer patients for surgery should include low-molecular weight or unfractionated heparin unless contraindicated. By contrast, in outpatients with cancer, routine anticoagulant prophylaxis is recommended only for patients with myeloma receiving thalidomide-based regimens.
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PMID:[Cancer and thrombosis]. 1992 Mar 77

Plasmacytoid urothelial carcinoma (PUC) is a very rare variant of urothelial carcinoma with an aggressive clinical course. According to small series reported to date, it is a high grade cancer usually diagnosed at an advanced stage, and with poor prognosis. Descriptions of the cytologic features of this type of carcinoma in literature are limited. Plasmacytoid appearance of tumor cells could cause diagnostic dilemma and potential incorrect diagnosis as multiple myeloma (MM). This report describes cerebrospinal fluid, bone marrow, and urine sediment cytomorphologic and immunocytochemical findings in a patient with meningeal carcinomatosis as the first manifestation of a PUC, initially misdiagnosed as MM with a brief review of the literature.
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PMID:Plasmacytoid urothelial carcinoma--diagnostic challenge in cytology. 2255 58