Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026764 (multiple myeloma)
 36,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The crystalline keratopathy of multiple myeloma may involve the corneal epithelium, but has not previously been described in a vortex epithelial distribution. Endocapsular hematomas have been described in the period immediately after extracapsular cataract extraction, but not later on or in association with systemic disease. We report a pseudophakic patient who developed a vortex epithelial crystalline keratopathy as a presenting sign of multiple myeloma, and who subsequently developed a spontaneous endocapsular hematoma.
Cornea 1992 Nov
PMID:Multiple myeloma presenting as vortex crystalline keratopathy and complicated by endocapsular hematoma. 146 23

A 52-year-old male developed bilateral subepithelial amorphous corneal deposits as well as diffuse noniridescent anterior stromal haze of unknown etiology. The deposits increased in density and a penetrating keratoplasty was performed in one eye when vision became sufficiently compromised. Pathological evaluation of the tissue included light and electron microscopy and immunohistochemical studies. The deposits were identified as monoclonal IgG kappa immunoglobulins and a systemic workup confirmed the diagnosis of a previously unsuspected multiple myeloma. The clinical course was characterized by the noncrystalline nature of the deposits, recurrence of the myeloma protein within the graft, and the poor response of the cornea to systemic therapy. In addition, profound ocular morbidity occurred, with a final visual acuity of 20/200 OD and 20/400 OS.
Cornea 1989 Dec
PMID:Atypical corneal manifestations of multiple myeloma. A clinical, histopathologic, and immunohistochemical report. 250 36

A 52-year-old man was first examined because of bilateral superficial punctate keratitis. Slit-lamp examination disclosed numerous intraepithelial minute opacities in both corneas. A corneal biopsy revealed intraepithelial rhomboidal or rectangular crystals that immunohistochemically stained only for IgG-kappa. Serum immunoelectrophoresis demonstrated an IgG-kappa monoclonal gammopathy. Over the ensuing 6 years, the clinical appearance of the crystals changed from small dot-like opacities to polychromatic crystals. At this time, bone marrow examination established the diagnosis of multiple myeloma. Ophthalmologists should be aware of this entity and carefully monitor these patients; the corneal lesions may be the initial manifestation of an asymptomatic monoclonal gammopathy preceding the development of multiple myeloma.
Cornea 1993 Sep
PMID:Intraepithelial corneal immunoglobulin crystals in IgG-kappa multiple myeloma. 830 67

The deposition of copper on Descemet's membrane and the anterior and posterior lens capsule with extreme hypercupremia and IgG hypergammaglobulinemia has been previously described with multiple myeloma and pulmonary carcinoma. A 66-year-old man presenting with blurred vision was found to have bilateral golden-brown metallic dust-like deposits on the central region of Descemet's membrane and the anterior and posterior lens capsule. Laboratory investigations revealed an elevated serum copper level 10 times the normal level associated with a monoclonal gammopathy and a normal ceruloplasmin level. Copper binding to the serum proteins was investigated by three biochemical methods. The results demonstrated that the major copper binding fraction in the serum was IgG. N-terminal amino acid analysis of the IgG did not find the sequence of Asp-Ala-His, which has been shown to be a copper binding site in albumin. This is the first report of benign monoclonal gammopathy being associated with the ocular deposition of copper.
Cornea 1996 Jan
PMID:Ocular copper deposition associated with benign monoclonal gammopathy and hypercupremia. 890 88