Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026764 (multiple myeloma)
 36,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

From January 1984 to March 1987, eleven cases of multiple myeloma were registered in the Department of Radiotherapy, Safdarjang Hospital, New Delhi, giving an incidence of more than three cases per year. The cases had age distribution ranging 40-90 years, the youngest being 40 years and oldest 85 years. The majority were in their sixties. Majority were males. Moderate aches and pain either all over the body or confined to a region along with lethargy and weakness were the commonest presenting symptoms. Lytic bone lesions was the commonest complication. One case had cranial nerve involvement.
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PMID:A profile of multiple myeloma cases (study of eleven cases). 280 36

Novel treatment strategies have remarkably improved the multiple myeloma (MM) patients' survival, with associated increased costs. A joint panel meet of international experts from India and Ukraine was held in New Delhi on May 19, 2016 focusing on MM management, bortezomib role, unmet medical needs, and current challenges. The health-care system for oncology in India is majorly private vs. government-based in Ukraine. In India, electrophoresis, serum-free light chain assays, bone marrow tests, and X-rays are available modes of diagnosis. Despite of the numerous cancer centers and stem cell transplant centers, most patients do not prefer transplant owing to its high-cost and social stigma. Majority of the patients are treated with bortezomib or lenalidomide-based regimens. Most patients buy drug themselves. The expanding generic drugs market is a ray of hope for the affordable drugs. In Ukraine, immuno-fixation, bone marrow analysis, and magnetic resonance imaging are common diagnostic modalities. Due to high cost, only few patients undergo transplant. Bortezomib-based regimens are preferred in most of the patients; however, usage is limited due to high costs and lack of funds. Thalidomide-based regimens are used for maintenance therapy due to affordability. In case of relapsed MM, bortezomib is preferred in triple therapy; however, more affordable option is cyclophosphamide, thalidomide, and dexamethasone (CTD). Issues, such as cost containment, common treatment strategies, enhanced collaboration, and improved health-care access, need immediate attention. High-quality generics access will improve outcomes and support health-care cost containment. Pharmacoeconomic studies and head-to-head trials are warranted to determine the cost-effectiveness and benefit of novel therapies in MM.
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PMID:Management of Multiple Myeloma and Usage of Bortezomib: Perspective from India and Ukraine. 2791 69

Since last few years plasma cell dyscrasias have been in the hit list of research especially pertaining to its therapy and pathophysiology. India has taken a great leap as far as research in plasma cell dyscrasias is concerned. The year started with myeloma conference in New Delhi conducted by Army Hospital (R&R) and ended at Haematocon Kochi organised by team from CMC Vellore (Haematocon 2018). Haematocon 2018 provided an exceptional platform for the research on various aspects of plasma cell dyscrasias both from the country and abroad. A total of 23 abstracts were presented pertaining to plasma cell disorders; 13 original research papers, 08 case reports and 02 case series. There were a wide spectrum of papers which ranged from the discussion about morphological aspects, mimickers, clinical spectrum, life style in the setting of the disease, diagnostic modalities to management aspects and finally to progress and survival of these patients. Through this review we will summarize and analyze the key findings of the original research abstracts on diagnosis, risk stratification, clinical profile and treatment aspects of plasma cell disorders presented at the Haematocon 2018.
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PMID:Highlights of Abstracts on Plasma Cell Dyscrasia in the Annual Conference ISHBT (Kochi). 3082 44