Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026764 (multiple myeloma)
 36,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The term tubulointerstitial nephropathy (TIN) means a renal disease, during which the tubules and interstice form a substrate of the primary injury or a substrate whose involvement is dominating in the disease clinical picture. The incidence of TIN is fairly high, with different etiology and pathogenesis. Drug, virus, bacterial and immune patterns are among the most common types of acute TIN. It is shown that the incidence of chronic drug TIN ranges from 0.2% among urban population to 0.6% among rural population. The incidence and gravity of renal injuries in hyperuricemia depend on the blood uric acid content. Study of the incidence and character of TIN in hypercalcemia in patients with sarcoidosis, hyperparathyrosis and multiple myeloma demonstrates the character of tubulointerstitial lesions to depend on the structure of paraprotein. In systemic lupus erythematosus, tubulointerstitial lesions are detected in 50% of cases. Such a comprehensive treatment of TIN opens up new vistas in the prophylaxis and therapy of this illness.
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PMID:[Tubulointerstitial nephropathies]. 390 89

Immunoelectrophoretic study of serum proteins in patients with various types of malignant proliferations of haemopoietic tissue was performed. It was established that myeloproliferative diseases (chronic myeloleukemia, acute leukemia) are notable for changes in alpha 2-globulins (frequent increase in the content of alpha 2-macroglobulin, haptoglobin) increase in the of beta 1 A-globulin as well as for reactive increase in the content of one or several immunoglobulins. During malignant proliferations of lymphoreticular tissue (chronic lympholeukemia, lymphosarcoma, myeloma, lymphogranulomatosis), major disturbances occur in the group of immunoglobulins, changes in which during this pathology can be of three types: reactive increase, decrease with a syndrome of antibody deficiency, paraproteinemia. The type of changes of immunoglobulins is determined by morphogenetic species of malignant cells.
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PMID:[Immunoelectrophoretic characterization of the changes in serum proteins in hemoblastosis]. 531 20

Serum angiotensin-converting enzyme (SACE) was analysed in 27 patients with Hodgkin's disease, 25 with non-Hodgkin lymphoma, 14 with acute leukaemia, 15 with chronic leukaemia, and 15 with multiple myeloma. SACE was depressed in these patients as a whole, with a mean level of 19.9 mu/ml, compared with 116 healthy controls (mean 24.4 mu/ml, P < 0.001). This depression was greatest in chronic leukaemia and multiple myeloma. In Hodgkin's disease no relationship was found between enzyme activity and stage, activity, histopathology, treatment, mediastinal involvement or prognosis. In non-Hodgkin patients a poor prognosis was generally associated with low SACE activity. The low SACE activity was not related to recent corticosteroid treatment, and the cause and pathophysiological significance is unexplained. Since SACE is high in the granulomatous disorder sarcoidosis (which can mimic malignant lymphnode and blood diseases) SACE analysis can be valuable in evaluating patients with mediastinal lymphadenopathy and those in whom non-caseating epitheliod granulomas are found.
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PMID:Serum angiotensin-converting enzyme in malignant lymphomas, leukaemia and multiple myeloma. 625 27

A study was made of the effect of lithium carbonate on the blood leukocyte count, absolute neutrophil and monocyte counts in 32 patients with neutropenia caused by the use of a specific treatment for lymphogranulomatosis (LGM), malignant lymphomas and multiple myeloma (MM), and in 5 patients with hypoplastic anemia (HA). Administration of lithium carbonate led to a significant increase in the total leukocyte and neutrophil counts in patients with LGM, malignant lymphomas and MM but not in patients with HA. The rise of the neutrophil count detected before (after 3 days) suggests that lithium may exert a direct stimulant action on relatively mature myeloid cells (promyelocytes and even myelocytes) but not on the undifferentiated colony-forming cells. The exponential dependence was found between an increase in the neutrophil count and duration of lithium intake, which permits forecasting the expected rise in the counts of these cells.
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PMID:[Stimulating effect of lithium carbonate on neutropoiesis in iatrogenic neutropenia]. 643 1

An unusual case of multiple myeloma with extramedullary dissemination and co-existing systemic non-necrotic granulomas is described. Immunoperoxidase staining revealed that both lymph node and bone marrow infiltrating plasma cells contained the same IgG-lambda type paraprotein, and that the granuloma epithelioid histiocytes contained intracytoplasmic lysozyme. As there was no evidence of either systemic infection or sarcoidosis, the non-necrotic granulomas may represent the host's response to the myeloma, not unlike the reaction observed in Hodgkin's disease or solid tumours. A causal association cannot, however, be entirely excluded.
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PMID:Multiple myeloma with a sarcoidosis-like reaction. 675 57

Most cases of calcium deposition seen radiologically in soft tissues are caused by calcium hydroxyapatite and occur either as a complication of trauma with associated necrosis (eg, fat necrosis), generalized connective tissue diseases (eg, scleroderma), metabolic disturbances (eg, hyperparathyroidism, familial hyperphosphatemia), sarcoidosis, myeloma, or metastases. Hydroxyapatite deposits are seen at many soft tissue sites, including joint capsules, ligaments, blood vessels, dermis, etc. On the other hand, deposits of calcium pyrophosphate are seen typically in the meniscus, articular cartilage, ligamentum flavum, and intervertebral disc. They usually are punctate or linear in distribution within the meniscus or parallel to the subchondral bone end plate. We report seven cases of massive focal calcium pyrophosphate dihydrate (CPPD) crystal deposition disease (tophaceous pseudogout) that occurred in atypical locations for CPPD. The ages of the patients ranged from 31 to 86 years (average, 60.7 years). One patient was male and six were female. The temporomandibular joint was involved in three patients and the metatarsophalangeal joint of the great toe was involved in two patients. The hip joint and cervical spine were involved in one patient each. A mass or swelling with or without pain was a common symptom. None of the patients in our series had clinical or radiographic evidence of CPPD crystal deposition disease in any other joints. Roentgenograms showed calcified lesions with a granular or fluffy pattern. Histologically, the lesions showed small or large deposits of intensely basophilic calcified material containing needle shaped and rhomboid crystals with weakly positive birefringence characteristic of CPPD. Foreign body granulomatous reaction to the CPPD deposition was constantly found. Chondroid metaplasia around and in the areas of CPPD deposition was observed commonly. Some of the chondroid areas showed cellular atypia in chondrocytes suggestive of a malignant cartilage tumor. It is important to recognize this rare form of CPPD crystal deposition disease and to identify the CPPD crystals in the calcified deposits, thus avoiding the misdiagnosis of benign or malignant cartilaginous lesions.
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PMID:Tophaceous pseudogout (tumoral calcium pyrophosphate dihydrate crystal deposition disease). 777 86

Hypercalcemia may be a manifestation of a variety of disorders including hyperparathyroidism, hypervitaminosis D, sarcoidosis, multiple myeloma, hyperthyroidism, acute osteoporosis, metastatic bone disease, and a number of primary malignancies. Hypercalcemia may be seen in as many as 1.5% of all patients with malignant disease, with or without bony metastases. The neoplasms most commonly associated with hypercalcemia include carcinoma of the lung (all cell types), breast cancer, squamous cell carcinomas, hematologic malignancies, and renal cell carcinoma. Observation of a number of instances of hypercalcemia attendant on urologic malignancies prompts the brief report of 4 characteristic cases with documentation of response to therapy. Management of severe and debilitating hypercalcemia is emphasized. Urologists should be aware of new agents available for such treatment.
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PMID:Hypercalcemia and urologic malignancies. 781 68

Endobronchial streptokinase has been used previously to dissolve blood clots caused by massive spontaneous hemoptysis, in settings including sarcoidosis, cavitary histoplasmosis, and multiple myeloma. To our knowledge, however, the use of thrombolytic agents to dissolve clots following transbronchial biopsy has not been reported previously. We describe a patient in whom endobronchial urokinase was used for successful dissolution of clots secondary to massive bleeding after transbronchial biopsy.
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PMID:Endobronchial urokinase for dissolution of massive clot following transbronchial biopsy. 813 76

A clinical course of herpes zoster in hematological patients (chronic lympholeukosis, lymphogranulomatosis, acute leucosis, myeloma disease, chronic agranulocytosis) is presented. These patients exhibited a more severe course of herpes zoster that is caused by immunodeficiency state. It is judicious to treat the patients with reaferon.
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PMID:[Herpes zoster in hematology patients]. 819 11

We report the case of an adult West Indian patient who presented with heart failure 20 years after an initial diagnosis of pulmonary sarcoidosis. Endomyocardial biopsy revealed AL type amyloid which was later found to be secondary to an underlying multiple myeloma.
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PMID:Sarcoid, amyloid and heart failure. 828 46


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