Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0026764 (multiple myeloma)
 36,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We describe a case of solitary extramedullary plasmacytoma of the oropharynx growing on the left posterior tonsillar pillar. The clinical picture was difficulty in swallowing caused from the partial obstruction of the area and bleeding from the ulcerated tumor. Lambda light chains were identified on immunohistochemical staining but they were not detected in either serum or urine (non-secreting tumor). Excisional biopsy followed by radiation therapy were used for treatment. Long-term follow up for several years is necessary in order to rule out evolution to multiple myeloma.
Ear Nose Throat J 1993 Nov
PMID:Solitary extramedullary plasmacytoma of the oropharynx: a rare location. 826 30

Three cases of light chain kappa amyloidosis in multiple myeloma patients are described with remarkable involvement of the tongue and swelling of the sublingual and submandibular regions, and without signs of nephropathy despite Bence Jones kappa proteinuria. All three patients had carpal tunnel syndrome at the beginning of their disease course and only moderate gastrointestinal involvement. Primarily for prognostic reasons, amyloidosis should be suspected in such cases, even in the presence of these highly unusual manifestations, and the diagnosis should be confirmed by unambigously-positive biopsies.
Ear Nose Throat J 1998 Feb
PMID:Combined bilateral submandibular and sublingual swelling, macroglossus, and carpal tunnel syndrome caused by light chain amyloidosis. 950 22

Multiple myeloma, which primarily affects the elderly, is rare in the head and neck. We report the case of a 71-year-old man who came to us with hoarseness, dysphagia, intermittent aspiration, and cervical lymphadenopathy. Our work-up included laboratory tests, radiographic examinations, analysis of bone marrow aspiration, and histopathologic evaluations. Cervical lymph node biopsy confirmed a diagnosis of multiple myeloma. Despite treatment with chemotherapy and radiation, the patient died of his disease 6 months later.
Ear Nose Throat J 2004 Apr
PMID:Multiple myeloma in a patient with hoarseness, dysphagia, aspiration, and cervical lymphadenopathy. 1514

Amyloidosis is characterized by an abnormal extracellular deposition of amyloid in different tissues and organs, where it usually causes some type of dysfunction. Its cause is unknown. The two main forms of amyloidosis are systemic and localized; the latter is rare. No satisfactory treatment for systemic amyloidosis has been discovered, and mean survival is poor, ranging from 5 to 15 months depending on the presence or absence of multiple myeloma. We report a case of primary systemic amyloidosis in a 71-year-old man. The diagnosis of amyloidosis was established by tongue biopsy, and its systemic nature was identified by analysis of aspirated abdominal fat. At the 1-year follow-up, the patient's clinical condition had not changed, and he was thereafter lost to follow-up.
Ear Nose Throat J 2005 Jun
PMID:Macroglossia secondary to systemic amyloidosis: case report and literature review. 1607 59

We report a rare case of extramedullary plasmacytoma of the nasal septum in a 65-year-old woman. She presented with a 2-month history of left-sided nasal obstruction and intermittent blood-tinged nasal crusting. Nasal endoscopy revealed that a dark-red mass had arisen from the nasal septum; no evidence of invasion to adjacent tissues was seen. A biopsy specimen was diagnosed as a plasmacytoma (kappa light chain-type). Serum and urine electrophoresis failed to detect any myeloma component or Bence Jones protein. All other screening tests to rule out multiple myeloma were negative. These findings confirmed the diagnosis of extramedullary plasmacytoma. The mass was completely removed via an endoscopic approach. No recurrence was noted at the 2-year follow-up.
Ear Nose Throat J 2005 Nov
PMID:Extramedullary plasmacytoma arising from the nasal septum. 1638 Nov 36

Extramedullary plasmacytoma involving the skull base is rare. We describe what we believe is the first reported case of recurrent multiple myeloma presenting as an isolated lesion in the central skull base in a patient with no evidence of systemic involvement. We discuss the patient's presentation, clinical course, and treatment, and we review the relevant scientific literature.
Ear Nose Throat J 2007 Sep
PMID:Recurrence of isolated multiple myeloma in the skull base: a case report and review of the literature. 1797 Jan 46

Extramedullary plasmacytoma is a rare plasma cell neoplasm that can occur in the head and neck. In this article we describe a case of multiple synchronous extramedullary plasmacytomas involving the upper airway, pharynx, and larynx. The clinical, imaging, and pathologic features of this neoplasm are discussed, together with potential treatment options.
Ear Nose Throat J 2007 Sep
PMID:Extramedullary plasmacytomas of the larynx and parapharyngeal space: imaging and pathologic features. 1797 Jan 49

Laryngeal plasmacytoma is rare in Japan; to the best of our knowledge, only 8 other cases have been previously reported. We report a new case of extramedullary plasmacytoma of the larynx in a 76-year-old Japanese woman. Immunohistochemical investigation revealed that her disease had not progressed to multiple myeloma. The patient declined radiotherapy, and her condition remained stable at the 6-month follow-up.
Ear Nose Throat J 2007 Dec
PMID:Extramedullary plasmacytoma of the larynx: a case report from Japan. 1821 84

Extramedullary plasmacytoma is uncommon, accounting for only 3% of all plasma cell neoplasms. Most lesions occur in the head and neck, primarily in the upper aerodigestive tract; only a minority occur in the larynx. Most cases of extramedullary plasmacytoma are seen in older men; presentation in an adolescent is rare. We report the case of a 13-year-old girl who presented with a 2- to 3-month history of progressive dysphonia. Physical examination identified two lesions--a nasopharyngeal mass and a laryngeal mass. Biopsy indicated that the masses were extramedullary plasmacytomas with amyloid deposition. The patient was treated with radiation therapy, and the tumors were eradicated. We also review the literature with respect to the epidemiology and presentation of extramedullary plasmacytoma of the head and neck, specifically those that affect the larynx.
Ear Nose Throat J 2009 Feb
PMID:Extramedullary plasmacytoma of the larynx in an adolescent: a case report and review of the literature. 1922 68

Simultaneous extramedullary plasmacytoma of the nasopharynx and larynx is exceedingly rare; to the best of our knowledge, only 1 other case has been previously reported. We report a new case, which occurred in a 46-year-old woman. She was treated with a combination of surgery, radiotherapy, and chemotherapy. At 2 years of follow-up, no evidence of recurrence or progression to multiple myeloma was noted. We discuss the clinical features and treatment of plasma cell neoplasms in general and their three variants in particular.
Ear Nose Throat J 2009 Nov
PMID:Synchronous presentation of extramedullary plasmacytoma in the nasopharynx and the larynx. 1992 56


1 2 Next >>