Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0026764 (
multiple myeloma
)
36,148
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The concept of autoimmune hyperlipidemia was proposed originally by Beaumont et al. Since then, hyperlipidemic patients with autoantibodies to circulating lipoproteins as well as enzymes related to lipoprotein metabolism have been documented. However, the mechanism remains speculative except in a few cases. We described a patient with autoimmune
hyperchylomicronemia
due to autoantibodies against lipoproteins lipase and hepatic triglyceride lipase. We also identified a hyperlipidemic case with inhibitory monoclonal antibodies against low density lipoprotein binding to fibroblasts and
multiple myeloma
. These data suggest that screening of patients with nonfamilial hyperlipidemia, especially those with associated autoimmune diseases, may result in the identification of other such patients.
...
PMID:[Autoimmune hyperchylomicronemia]. 1063 10
