Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0026764 (multiple myeloma)
 36,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Specific antibody binding activity directed against pituitary tissue was demonstrated in a typical case of POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) syndrome with paraproteinemia of IgG lambda type. IgG binding against various other tissues could not be detected by immunoelectroblotting and immunocytochemistry. We propose that POEMS syndrome is an antibody-mediated immune disorder, in which the hypophysis is the primary target of the pathologic myeloma antibodies. The immunopathogenetic lesion of the hypophysis could induce secondary disturbances of other organs, thus explaining the multisystemic disorder.
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PMID:Specific antibody activity against neuroendocrine tissue in a case of POEMS syndrome with IgG gammopathy. 283 85

We report a case of diffuse large B-cell lymphoma occurring in a patient with the hyperimmunoglobulinemia E syndrome, a rare immune disorder defined by elevated immunoglobulin E levels and recurrent bacterial and fungal infections often manifesting as cold abscesses. This case further supports the notion that patients with hyperimmunoglobulinemia E have an increased risk of lymphoid malignancies and should be closely monitored. Despite a theoretic risk of severe infectious complications, chemotherapy was well tolerated and resulted in a sustained complete remission.
Clin Lymphoma Myeloma 2007 May
PMID:[18F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography for early evaluation of treatment efficacy in advanced non-Hodgkin lymphoma of uterine corpus: a case report. 1762 8

We report a case of diffuse large B-cell lymphoma occurring in a patient with the hyperimmunoglobulinemia E syndrome, a rare immune disorder defined by elevated immunoglobulin E levels and recurrent bacterial and fungal infections often manifesting as cold abscesses. This case further supports the notion that patients with hyperimmunoglobulinemia E have an increased risk of lymphoid malignancies and should be closely monitored. Despite a theoretic risk of severe infectious complications, chemotherapy was well tolerated and resulted in a sustained complete remission.
Clin Lymphoma Myeloma 2007 May
PMID:Diffuse large B-cell lymphoma in hyperimmunoglobulinemia E syndrome. 1762 9