Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0026764 (multiple myeloma)
 36,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During examination of a biopsy specimen of skin by conventional microscopy, numerous round, basophilic, extracellular bodies suggestive of fungal organisms were seen in the dermis. Further evaluation and special staining suggested that their origin was from the plasma cells. Examination of biopsy material from 48 patients with cutaneous plasma cell infiltrates revealed similar bodies in 20 cases (42%). Sizes of bodies varied, the largest being 5.0 microns in diameter. In every case, staining reactions were identical to those of plasma cell cytoplasm. Immunoperoxidase methods showed that, like plasma cells, the bodies contained either kappa or lambda light chains. In one case of plasmacytoma associated with multiple myeloma, both the bodies and the surrounding neoplastic cells stained for kappa chains only. Electron microscopy revealed rounded structures composed of aggregates of rough endoplasmic reticulum, which contained varying amounts of moderately electron-dense material within the cisternae. Fragmented plasma cells were also seen. The evidence suggests that plasma cell bodies are distinct from Russell bodies. They probably form as a result of trauma during processing of tissue, but could also represent a degenerative process in vivo. They should be distinguished from pathogenic micro-organisms and other extracellular bodies.
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PMID:An extracellular body of plasma cell origin in inflammatory infiltrates within the dermis. 308 27

A 58-year-old man with multiple myeloma presented with a 3-month history of a sensation of occipital pressure, transient blurring of vision and increased bone pain. Funduscopic examination revealed disc swelling, tortuous veins and superficial retinal hemorrhages simulating early hyperviscosity syndrome. Clinical investigation and computerized tomography, however, indicated that an intracranial plasmacytoma was the cause of his papilledema. Cobalt 60 beam therapy and vincristine were added to his treatment regimen. Seven weeks later the intracranial tumour had almost totally disappeared. Symptomatic cerebral compression from an intracranial plasmacytoma associated with systemic disease is uncommon. The diagnosis and management are reviewed.
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PMID:Intracranial plasmacytoma associated with multiple myeloma. 649 5

Two cases of oculomotor nerves involvement as uncommon initial manifestation of a parasellar extramedullary plasmacytoma are reported. The first patient presented with an isolated left VI cranial nerve palsy; the second one had an incomplete left III cranial nerve palsy. In both cases clinical investigation and computed tomography revealed an intracranial plasmacytoma associated with multiple myeloma. It is important to underline the difference between an intracranial extramedullary plasmacytoma and a plasmacytoma associated with multiple myeloma. In fact the absence of a general associated illness should show a most favourable course.
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PMID:[Isolated oculomotor palsy disclosing multiple myeloma]. 874 10

Plasmacytoma is a malignant tumour composed of plasma cells. Most commonly this takes the form of a plasma cell infiltration of bone marrow-multiple myeloma. This may be seen radiologically as either discrete lytic lesions or diffuse osteoporosis. Plasma cells are seen on bone marrow biopsy, and monoclonal immunoglobulins may occur in plasma and/or urine. Less frequently, plasma cell tumours may present as a solitary myeloma of bone, which often progresses to multiple myeloma, or as a plasma cell leukemia. Primary plasma cell tumours in an extramedullary site are relatively rare. Such soft tissue plasmacytomas usually occur in the nasopharynx or conjectiva, and are seldom located in the lower gastrointestinal tract. We report a case of primary plasmacytoma associated with a diverticular stricture in the sigmoid colon, an occurrence not previously documented, and review the current literature.
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PMID:Plasmacytoma of the sigmoid colon associated with a diverticular stricture: case report and review of the literature. 904 47

An unusual case of breast plasmacytoma associated with a multiple myeloma is reported. Breast plasmacytoma is exceedingly rare. We identified 37 cases published between 1928 and 1999, and reviewed the clinical features of this unusual presentation of plasmacytoma.
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PMID:Breast plasmacytoma. 1104 22

A 70-year-old woman was admitted for anemia, elevated serum total protein and a right axillary mass. Laboratory data showed monoclonal x IgM with a decrease in serum IgG and IgA levels. An occipital punched-out lesion was detected on a cranial X-ray. A tumor lesion was detected on chest X-ray and computed tomography. Biopsy specimen revealed plasmacytoma with cytoplasmic IgM. Bone marrow aspiration revealed an elevated plasma cell count. An immunophenotype analysis of the plasma cells showed positivity of cytoplasmic IgM, x, CD5, CD38, CD11a (LFA-1), CD44 (HCAM), CD49d (VLA-4) and CD54 (ICAM-1). From the above results, we diagnosed the patient as having IgM myeloma associated with plasmacytoma. Melphalan and prednisolone therapy were prescribed, their effect on the myeloma was short term, so we changed the chemotherapy to VAD (vincristine, adriamycin and dexamethasone), but this treatment had little effect. The patient developed bacterial pneumonia and died. IgM myeloma is a rare disease and reports of immunophenotype analysis are also rare. There is no case report of plasmacytoma associated with IgM myeloma.
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PMID:[IgM type multiple myeloma expressing various surface adhesion molecules and demonstrating an aggressive clinical course]. 1457 17

Multiple myeloma is a neoplastic proliferation of monoclonal plasma cells. Symptomatic gastrointestinal involvement is uncommon. We report the case of a 45-year-old patient admitted with an anorectal polypoid lesion, which progressed to colonic obstruction. Investigation revealed a secondary plasmacytoma associated with multiple myeloma. We discuss the characteristics of this rare entity with poor prognosis, its clinical implications and treatment options.
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PMID:Anorectal involvement in a patient with multiple myeloma. 2842 Jun 51