Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0025362 (mental retardation)
 15,878 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
X-linked 1332
Sep 1025
Mol 691
FMR1 424
MRI 290
FMRP 278
She 254
FISH 237
Rett syndrome 218
chromosome 21 208
fragile X mental retardation protein 177
telomeric 162
aniridia 144
X-linked recessive 135
RNA-binding protein 132
p11 118
axonal 116
cryptic 114
ATRX 114
X-chromosome 114
MECP2 113
MRX 107
strabismus 103
histone 97
thyroid hormone 92
MIM 92
ATR 86
Rubinstein-Taybi syndrome 86
WAGR 83
insulin 80
UTR 76
Smith-Lemli-Opitz syndrome 75
p13 73
TSC2 71
FRAXE 68
Rho 67
CA1 65
p22 64
TSC1 63
GABA 62
dystrophin 62
endoplasmic reticulum 58
p21 57
metabotropic glutamate receptor 55
hypoxanthine-guanine phosphoribosyltransferase 51
p53 51
olfactory 51
ARX 50
mTOR 50
amyloid precursor protein 49
reductase 48
Pol 47
fatty aldehyde dehydrogenase 47
neurofibromatosis 46
ATP 45
FMR1 protein 45
FMR2 45
ATPase 43
WT1 43
GTG 42
CSF 41
ubiquitin 40
Y chromosome 39
RNA binding protein 39
GTPase 39
phenylalanine hydroxylase 38
Sotos syndrome 38
Mot 37
L1CAM 37
DAG 36
XLMR 36
phosphatase 36
ICD 35
creatine kinase 35
RSH 35
growth hormone 34
creatine transporter 34
ADHD 34
dystrophin gene 34
DCX 34
collagen 33
brain-derived neurotrophic factor 33
prolidase 33
DMD 33
SLC6A8 33
tuberin 33
PAK3 32
p15 32
DAXX 32
unknown function 32
DYRK1A 32
polypeptide 31
MASA 31
OCRL1 31
MAPK 31
glial fibrillary acidic protein 31
PKU 31
IL1RAPL1 30
RSK2 30
L1 cell adhesion molecule 30
p23 30
p12 29
ribonucleoprotein 29
helicase 29
Fragile X Mental Retardation Protein 28
zinc finger 28
Walker 28
PAX6 28
CDT 27
transcriptional repressor 27
CA3 27
glycoprotein 27
cystathionine beta-synthase 27
novel gene 27
FXR2P 27
nerve growth factor 27
ATRX protein 27
UBE3A 27
hemoglobin 26
methyltransferase 26
SNF2 26
FXR1P 26
superoxide dismutase 26
histone H3 25
STS 25
DNMT3B 25
catalase 25
CDKL5 25
Aristaless-related homeobox 25
interacting protein 24
cytokine 24
BRAF 24
androgen receptor 24
B12 24
XNP 24
PSD-95 23
FXR1 23
LIS1 23
NIPBL 22
mGluR5 22
HRAS 22
alkaline phosphatase 22
PQBP1 22
glutamate receptor 21
MCPH1 21
threonine 21
monocarboxylate transporter 8 21
AMP 21
NMDA receptor 21
CBP 21
calmodulin 20
homeobox 20
SWI 20
parathyroid hormone 20
FSH 20
adaptor protein 20
NSD1 20
transcriptional regulator 20
trichothiodystrophy 20
ACTH 20
more...
Disease
mental retardation 15878
mental retardation 15395
epilepsy 1534
fragile X syndrome 1036
autism 1026
Down syndrome 785
developmental delay 636
cerebral palsy 518
obesity 344
schizophrenia 334
developmental disabilities 314
severe mental retardation 310
deafness 304
cancer 296
genetic disorder 289
tuberous sclerosis 273
trisomy 259
tumor 247
dysplasia 245
Rett syndrome 239
hydrocephalus 239
mental illness 234
psychosis 234
phenylketonuria 231
Autism 230
cognitive impairment 230
Alzheimer's disease 229
depression 223
mild mental retardation 217
dementia 209
hypothyroidism 204
hypogonadism 200
encephalopathy 200
HCG 194
cleft palate 184
moderate mental retardation 180
fits 178
heart disease 178
macrocephaly 170
thalassemia 166
congenital hypothyroidism 163
ichthyosis 155
aggression 152
Syndrome 145
WT1 142
blindness 141
diabetes 139
Williams syndrome 138
strabismus 138
FAS 133
cataract 122
ichthyosis 121
myopathy 116
prolapse 115
ATRX 114
West 112
scoliosis 112
ADHD 110
lissencephaly 109
failure to thrive 106
profound mental retardation 104
Bardet-Biedl syndrome 103
spastic paraplegia 102
learning disability 101
retinitis pigmentosa 101
cytomegalovirus 99
Angelman syndrome 99
tetraplegia 97
Duchenne muscular dystrophy 96
malnutrition 92
nystagmus 92
brain atrophy 92
muscular dystrophy 90
sensorineural hearing loss 87
hemiparesis 86
hypertension 84
Smith-Lemli-Opitz syndrome 83
FRAXA 82
craniosynostosis 81
Phenylketonuria 81
homocystinuria 80
neurological disease 80
glaucoma 79
self-injurious behavior 79
KMS 77
stroke 77
abortion 76
optic atrophy 75
PDD 75
cardiomyopathy 74
DM1 74
Turner syndrome 70
spastic diplegia 70
mole 70
bipolar disorder 69
SWS 68
metabolic disorder 67
peripheral neuropathy 67
leukemia 65
Cornelia de Lange syndrome 65
Parkinson's disease 65
mental handicap 65
hypogonadotropic hypogonadism 63
immunodeficiency 62
hypoglycemia 61
neuropathy 61
Congenital hypothyroidism 61
Lesch-Nyhan syndrome 60
aortic stenosis 60
anemia 60
goiter 60
FRAXE 60
Huntington's disease 59
status epilepticus 59
SMS 59
alcoholism 58
renal failure 57
muscular atrophy 57
osteoporosis 56
CLS 56
Lowe syndrome 55
myopia 52
congenital disorder 52
brain dysfunction 51
anhidrosis 51
substance abuse 50
renal disease 50
Wolf-Hirschhorn syndrome 50
retinopathy 49
Costello syndrome 49
hypertrophic cardiomyopathy 49
hernia 49
pachygyria 49
Sotos syndrome 49
infertility 48
mole 48
pneumonia 47
hyperphenylalaninemia 47
blepharophimosis 46
neurofibromatosis 46
Cockayne syndrome 46
coma 46
atrial septal defect 45
rare disease 45
parkinsonism 45
Dandy-Walker malformation 44
ventricular septal defect 44
choreoathetosis 44
prematurity 44
syndrome X 44
Cohen syndrome 43
intellectual impairment 43
brachycephaly 43
alpha thalassemia 42
pseudohypoparathyroidism 41
movement disorder 41
growth hormone deficiency 41
Lennox-Gastaut syndrome 41
ICD 40
thrombocytopenia 40
more...
Symptom
seizures 1557
hypotonia 568
ataxia 406
weakness 204
spasticity 196
cerebellar ataxia 152
pain 135
tremor 133
anesthesia 128
dystonia 94
hemiplegia 63
vomiting 63
dysarthria 63
myoclonus 62
hepatosplenomegaly 55
headache 52
constipation 51
diarrhea 44
paraparesis 40
agitation 34
paresis 30
lethargy 28
hepatomegaly 25
thinning 23
sleepiness 23
hypertonia 22
respiratory distress 22
splenomegaly 21
enuresis 21
abdominal pain 20
drooling 19
ataxic gait 19
overweight 18
ophthalmoplegia 18
chorea 17
regurgitation 17
fatigue 16
insomnia 16
tonic-clonic seizure 16
partial seizure 15
incoordination 15
photophobia 15
polyuria 15
cyanosis 13
hypothermia 13
intention tremor 13
chronic constipation 13
catatonia 12
dyspnea 12
polydipsia 12
stigma 12
athetosis 12
pallor 11
fasciculation 11
clumsiness 10
abnormal gait 10
prominent nose 10
analgesia 10
cough 9
hyperacusis 9
anosmia 8
myalgia 8
dizziness 8
anorexia 8
nausea 8
physical appearance 8
ENT 8
hunger 7
DNA marker 7
cachexia 7
vertigo 6
spasm 6
starvation 6
apathy 6
hemoptysis 6
Physical findings 6
collapse 6
memory loss 6
clonus 6
tachypnea 6
stridor 5
erythema 5
masculinization 5
joint stiffness 5
distraction 5
consciousness disturbance 5
Psychiatric symptoms 5
abnormal breathing 5
decreased appetite 5
clubbing 5
discomfort 5
snoring 5
syncope 4
hypersomnia 4
torticollis 4
bedwetting 4
hoarseness 4
tonic seizure 4
exhaustion 4
pachyonychia 4
HSA 4
muscle rigidity 4
nausea and vomiting 4
chromosome marker 4
paresthesia 4
dry skin 4
flank pain 4
Hudson 4
delayed language development 4
Sedation 3
Involuntary Movement 3
hypercapnia 3
discomfort 3
shortness of breath 3
livedo 3
numbness 3
acute stress 3
colic 3
hopelessness 3
fever of unknown origin 3
arthralgia 3
tinnitus 2
nasal discharge 2
hip pain 2
functional recovery 2
neurological disability 2
monoplegia 2
Ill 2
aphonia 2
forgetfulness 2
neck pain 2
blurred vision 2
angina 2
muscle stiffness 2
chest pain 2
abdominal cramps 2
neuralgia 2
emaciation 2
acidity 2
despair 2
Gastrointestinal symptoms 2
breath holding 2
generalized erythema 2
Respiratory abnormalities 2
Wind 2
testicular pain 1
heartburn 1
dental pain 1
infant diarrhea 1
tense 1
auditory hallucination 1
hypocapnia 1
Bitot's spots 1
stomach pain 1
urinary frequency 1
visual hallucination 1
hyperesthesia 1
Catch 1
bitter taste 1
Decreased activity 1
more...
Drug
Dermatol 161
lysine 57
CSF 41
Ethanol 28
Azithromycin 17
Zmax 17
Spectrum 16
Spectrum 16
Asn 14
AGG 14
DM1 13
BH4 11
ABC 11
Cardiovasc 10
ENT 9
lactose 9
Leaf 9
NADH 9
PTH 8
Frontal 8
Galactose 7
vitamin E 7
MAP 6
Phenytoin 6
Vitamin B 6
L-tyrosine 5
Growth hormone 5
Sodium valproate 5
Growth hormone 5
THF 5
OTC 4
OTC 4
caffeine 4
Mutagen 4
pyridoxal phosphate 4
Vitamin B12 4
CAM 4
EPA 4
Parkin 3
ascorbate 3
ETS 3
nitroglycerin 3
TTC 3
Cobalamin 3
Nephron 3
Monit 3
Parkin 3
VCR 3
Dial 2
Histamine 2
p75 2
ROS 2
Depo-Provera 2
CTX 2
Ganciclovir 2
Bayer 2
Meconium 2
CTA 2
CLS 2
Valganciclovir 2
Thioridazine 2
citric acid 2
Stiripentol 2
Gel 2
FAD 2
CTX 2
ampicillin 2
Calcium hopantenate 2
Propofol 2
Angiotensin II 2
Singular 2
Isotretinoin 2
BLM 2
ROC 2
niacin 2
CPR 2
Alliance 2
MRC 2
CTX 2
IFN-gamma 2
HCG 2
Vitamin A 2
Nephron 2
MgSO4 2
ADM 2
Fluconazole 1
Botox 1
Fosfluconazole 1
Tiopronin 1
CXN 1
Amiloride 1
PDL 1
PTC 1
ACT 1
Vitamin E 1
Amlexanox 1
Riboflavin 1
NAG 1
Prednisolone 1
TAC 1
Collodion 1
DBS 1
Adriamycin 1
Zonisamide 1
Retinoic acid 1
Fragment 1
TAT 1
Galsulfase 1
Piracetam 1
Adenosine deaminase 1
Copaxone 1
-deoxyadenosine 1
HPMPC 1
Prednisone 1
Namenda 1
BTC 1
Thyradin 1
AVC 1
Palmitoyl 1
Aloe 1
Idursulfase 1
Sonata 1
Metrizamide 1
Lipiodol 1
Senna 1
DMSA 1
DMAA 1
Ammonium chloride 1
ADR 1
Asthma 1
linolenate 1
DPA 1
Pyridoxal phosphate 1
Imatinib 1
TEL 1
Alanine 1
Senna 1
Estrogens 1
Luteinizing 1
Diastat 1
Doyle 1
Bevacizumab 1
Everolimus 1
Quetiapine hemifumarate 1
DNase I 1
G418 1
Suxamethonium chloride 1
Rimonabant 1
Aminoguanidine 1
CPO 1
Gabapentin 1
Sodium benzoate 1
Retinoic Acid 1
Portal 1
Rosiglitazone 1
GEO 1
CDP 1
SF6 1
EPI 1
Diurnal 1
more...
Enzyme
mitogen-activated protein kinase 79
protein kinase 70
ERK 64
ATPase 47
creatine kinase 41
phenylalanine hydroxylase 40
hypoxanthine-guanine phosphoribosyltransferase 40
superoxide dismutase 34
prolidase 32
catalase 32
RNA polymerase 27
cystathionine beta-synthase 27
MEK 24
alkaline phosphatase 22
7-dehydrocholesterol reductase 21
neuraminidase 19
luciferase 18
proteasome 17
glutathione peroxidase 16
ornithine transcarbamylase 16
demethylase 16
histone demethylase 16
glycine amidinotransferase 16
glycerol kinase 15
beta-galactosidase 15
arylsulfatase 13
sulfatase 13
calcineurin 13
protein kinase C 12
guanidinoacetate methyltransferase 12
glucoamylase 12
caspase-3 12
tyrosine aminotransferase 12
beta-glucuronidase 12
trypsin 12
NOS 12
NADH-cytochrome b5 reductase 12
alpha-mannosidase 11
alcohol dehydrogenase 11
acetylcholinesterase 11
sialidase 11
reverse transcriptase 11
cytochrome oxidase 11
aspartylglucosaminidase 11
carbonic anhydrase 11
focal adhesion kinase 11
isocitrate dehydrogenase 11
renin 10
tyrosine hydroxylase 10
CYP27A1 10
phosphoglycerate kinase 10
thyroid peroxidase 10
glucose-6-phosphate dehydrogenase 10
isocitrate dehydrogenase 10
complex I 9
alpha-L-iduronidase 9
biotinidase 8
choline acetyltransferase 8
succinic semialdehyde dehydrogenase 8
monoamine oxidase 8
spermine synthase 8
AMP-activated protein kinase 8
APC 8
adenylosuccinate lyase 8
pyruvate dehydrogenase 8
succinate dehydrogenase 8
aldehyde dehydrogenase 8
peroxidase 7
kinesin 7
STR 7
methylenetetrahydrofolate reductase 7
arginase 7
phosphodiesterase 7
methylenetetrahydrofolate reductase 7
dihydropteridine reductase 7
uridyltransferase 7
DNA polymerase 7
Lod 7
sulfite oxidase 7
PHD 7
sulfite oxidase 7
histone acetyltransferase 7
CaMKII 7
ceruloplasmin 7
alanine aminotransferase 7
aldehyde dehydrogenase 6
lactate dehydrogenase 6
endonuclease 6
tyrosinase 6
transcriptase 6
PAH 6
cholinesterase 6
aspartoacylase 6
ornithine aminotransferase 5
ubiquitin-protein ligase 5
inosine triphosphatase 5
mannanase 5
aldehyde dehydrogenase 5
phosphomannomutase 5
aldehyde dehydrogenase 5
phosphoinositide 3-kinase 5
phosphatidylinositol 3-kinase 5
pyruvate dehydrogenase 5
tissue plasminogen activator 5
glutathione reductase 5
pyruvate dehydrogenase 5
branched-chain alpha-keto acid dehydrogenase 5
diaphorase 5
citrate synthase 5
aldehyde dehydrogenase 5
RNase 5
xanthine dehydrogenase 5
4-hydroxyphenylpyruvate dioxygenase 5
NO synthase 5
acyl-CoA synthetase 4
xanthine oxidase 4
alpha-N-acetylglucosaminidase 4
PAL 4
aspartate aminotransferase 4
protein phosphatase 2A 4
guanylate kinase 4
ATP synthase 4
PAL 4
cathepsin D 4
enolase 4
glutamate dehydrogenase 4
glutamate dehydrogenase 4
arylsulfatase A 4
adenosine deaminase 4
thrombin 4
iduronate-2-sulfatase 4
CTD kinase 4
glutamate dehydrogenase 4
adenosine deaminase 4
AMPK 4
RNase 4
MAP 4
LIS 4
GABA transaminase 4
pyruvate carboxylase 4
acid phosphatase 3
glucocerebrosidase 3
CPR 3
phosphorylase 3
DNA methyltransferase 3
histidase 3
proline dehydrogenase 3
N-acetyltransferase 3
methionine adenosyltransferase 3
glyceraldehyde-3-phosphate dehydrogenase 3
mevalonate kinase 3
argininosuccinate synthetase 3
tryptophan hydroxylase 3
lipoxygenase 3
pyruvate kinase 3
methionine synthase 3
chaperonin 3
methionine synthase 3
proline oxidase 3
CPS 3
more...
Compound
Dec 1070
DNA 979
Clin 961
Retard 755
His 184
Phe 175
calcium 135
ethanol 126
water 119
glutamate 115
tyrosine 110
DSM 103
oxygen 101
arginine 97
MCA 93
MCA 93
glucose 91
iodine 84
sodium 66
serine 65
methionine 64
lysine 63
GABA 62
GTP 62
GABA 62
zinc 54
proline 53
phosphate 52
galactose 51
sulfate 51
leucine 48
Thyroid 48
potassium 47
homocysteine 47
ATP 46
TSH 46
urea 44
Neuronal 44
creatinine 41
iron 41
cysteine 39
threonine 36
alanine 35
copper 34
salt 33
DMD 33
AMPA 33
Ile 32
ammonia 30
valine 30
Pac 29
cAMP 29
gamma-aminobutyric acid 29
glutamine 28
nitric oxide 27
Cardiol 26
tryptophan 26
acetate 25
isoleucine 25
isoleucine 25
NMDA 25
PAC 24
tryptophan 24
tryptophan 23
silver 23
Creatine 23
tryptophan 23
Cereb 22
mercury 22
A 3 21
Asp 20
ACTH 20
AMP 20
CoA 19
hydrogen 19
Valproic acid 19
Gly 17
barium 17
nitrogen 17
BMD 16
N-acetylaspartate 16
COS 16
asparagine 16
ornithine 15
betaine 15
ornithine 15
ornithine 15
ornithine 15
Guo 15
Guo 15
ornithine 15
aldehyde 14
MEK 14
GDP 14
aspartic acid 14
CO2 14
Phenylalanine 14
aspartic acid 13
L-carnitine 13
DHC 13
pyrimidine 12
phosphocreatine 12
GSH 12
GSH 12
vitamin D 12
5-HT 11
aspartic acid 11
GMP 11
GAP 11
Estrogen 11
carbonate 11
SDS 11
pyrimidine 11
TNF 11
retinoic acid 11
Lead 11
Guanidinoacetic acid 11
aspartic acid 11
folinic acid 10
Insulin 10
Isoproterenol 10
Cholesterol 10
Risperidone 10
PAS 10
adenosylmethionine 10
NAD 10
phosphorus 9
selenium 9
pyridine 9
NADH 9
Microcephalin 9
DPH 8
aldehyde 8
6-12 8
5-hydroxytryptophan 8
H2S 8
IMP 8
cadmium 8
2-oxoglutarate 8
GAL 8
ammonium 8
Salt 8
coenzyme Q10 8
hydroxyglutarate 8
NAD 8
MAOA 8
Histone 7
Galactose 7
GlcNAc 7
A 1 7
CAT 7
CAM 7
glycerol 7
L-DOPA 7
Neurotol 7
PGA 7
molybdenum 7
PEG 7
CAT 7
CAT 7
more...